Gene/Proteome Database (LMPD)

LMPD ID
LMP002716
Gene ID
20597
Species
Mus musculus (Mouse)
Gene Name
sphingomyelin phosphodiesterase 1, acid lysosomal
Gene Symbol
Smpd1
Synonyms
A-SMase; ASM; Zn-SMase; aSMase
Alternate Names
sphingomyelin phosphodiesterase; acid sphingomyelinase
Chromosome
7
Map Location
7 E3|7 55.9 cM
EC Number
3.1.4.12

Proteins

sphingomyelin phosphodiesterase precursor
Refseq ID NP_035551
Protein GI 6755582
UniProt ID Q04519
mRNA ID NM_011421
Length 627
RefSeq Status VALIDATED
MPHHRASSGQDHLRAGWEQRLERSLPAPRVGLLWMGLGLALVLALFDSTVLWVPARAYPLPSEGHSVKFSAIAPPLQSAFGWQNLTCPACKVLFTALNHGLKKEPNVARVGSVAIKICKMLNIAPLDVCQSAVHLFEDDVVEVWTRSVLSPSEACGLLLGSSCGHWDIFSTWNISLPSVPKPPPKPPSPPAPGAPVSRVLFLTDLHWDHEYLEGTDPYCADPLCCRRGSGWPPNSQKGAGFWGEYSKCDLPLRTLESLLKGLGPAGPFEMVYWTGDIPAHDVWQQSRQDQLRALTTITDLVRKFLGPVPVYPAVGNHESTPVNGFPPPFIKGNQSSQWLYEAMAKAWEPWLPADALHTLRIGGFYALTPRPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVEELQAAENRGDKVHIIGHIPPGHCLKSWSWNYYKIIARYENTLAGQFFGHTHVDEFEIFYDEETLSRPLAVAFLAPSATTFINLNPGYRVYQIDGNYPGSSHVVLDHETYILNLTQANAAGGTPSWKRLYRARETYGLPDAMPASWHNLVYRMRDDEQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMPNGSLPDANRLWSRPLLC
sig_peptide: 1..44 inference: non-experimental evidence, no additional details recorded note: Potential; propagated from UniProtKB/Swiss-Prot (Q04519.2) calculated_mol_wt: 4885 peptide sequence: MPHHRASSGQDHLRAGWEQRLERSLPAPRVGLLWMGLGLALVLA mat_peptide: 45..627 product: Sphingomyelin phosphodiesterase experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q04519.2) calculated_mol_wt: 65061 peptide sequence: LFDSTVLWVPARAYPLPSEGHSVKFSAIAPPLQSAFGWQNLTCPACKVLFTALNHGLKKEPNVARVGSVAIKICKMLNIAPLDVCQSAVHLFEDDVVEVWTRSVLSPSEACGLLLGSSCGHWDIFSTWNISLPSVPKPPPKPPSPPAPGAPVSRVLFLTDLHWDHEYLEGTDPYCADPLCCRRGSGWPPNSQKGAGFWGEYSKCDLPLRTLESLLKGLGPAGPFEMVYWTGDIPAHDVWQQSRQDQLRALTTITDLVRKFLGPVPVYPAVGNHESTPVNGFPPPFIKGNQSSQWLYEAMAKAWEPWLPADALHTLRIGGFYALTPRPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVEELQAAENRGDKVHIIGHIPPGHCLKSWSWNYYKIIARYENTLAGQFFGHTHVDEFEIFYDEETLSRPLAVAFLAPSATTFINLNPGYRVYQIDGNYPGSSHVVLDHETYILNLTQANAAGGTPSWKRLYRARETYGLPDAMPASWHNLVYRMRDDEQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMPNGSLPDANRLWSRPLLC

Gene Information

Entrez Gene ID
20597
Gene Name
sphingomyelin phosphodiesterase 1, acid lysosomal
Gene Symbol
Smpd1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005615 IEA:Ensembl C extracellular space
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0042599 IEA:Ensembl C lamellar body
GO:0005764 IEA:UniProtKB-KW C lysosome
GO:0016798 IEA:UniProtKB-KW F hydrolase activity, acting on glycosyl bonds
GO:0004767 IEA:UniProtKB-EC F sphingomyelin phosphodiesterase activity
GO:0046513 IEA:Ensembl P ceramide biosynthetic process
GO:0043407 IEA:Ensembl P negative regulation of MAP kinase activity
GO:0043065 IEA:Ensembl P positive regulation of apoptotic process
GO:0035307 IEA:Ensembl P positive regulation of protein dephosphorylation
GO:0042220 IEA:Ensembl P response to cocaine
GO:0042493 IEA:Ensembl P response to drug
GO:0006685 IEA:InterPro P sphingomyelin catabolic process
GO:0023021 IEA:Ensembl P termination of signal transduction

KEGG Pathway Links

KEGG Pathway ID Description
mmu04142 Lysosome
mmu00600 Sphingolipid metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY3DJ-11281 sphingomyelin metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5893995 Glycosphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR029052 Metallo-dependent phosphatase-like
IPR008139 Saposin B
IPR011001 Saposin-like
IPR011160 Sphingomyelin phosphodiesterase

UniProt Annotations

Entry Information

Gene Name
sphingomyelin phosphodiesterase 1, acid lysosomal
Protein Entry
ASM_MOUSE
UniProt ID
Q04519
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Sphingomyelin + H(2)O = N-acylsphingosine + phosphocholine.
Function Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol.
Miscellaneous There are two types of sphingomyelinases: ASM (acid), and NSM (neutral).
Similarity Belongs to the acid sphingomyelinase family. {ECO:0000305}.
Similarity Contains 1 saposin B-type domain. {ECO:0000255|PROSITE-ProRule:PRU00415}.
Subcellular Location Lysosome.
Subunit Monomer.

Identical and Related Proteins

Unique RefSeq proteins for LMP002716 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6755582 RefSeq NP_035551 627 sphingomyelin phosphodiesterase precursor

Identical Sequences to LMP002716 proteins

Reference Database Accession Length Protein Name
GI:6755582 DBBJ BAC40171.1 627 unnamed protein product [Mus musculus]
GI:6755582 DBBJ BAE37659.1 627 unnamed protein product [Mus musculus]
GI:6755582 DBBJ BAE26489.1 627 unnamed protein product [Mus musculus]
GI:6755582 DBBJ BAE26598.1 627 unnamed protein product [Mus musculus]
GI:6755582 GenBank EDL16774.1 627 sphingomyelin phosphodiesterase 1, acid lysosomal, isoform CRA_b [Mus musculus]
GI:6755582 SwissProt Q04519.2 627 RecName: Full=Sphingomyelin phosphodiesterase; AltName: Full=Acid sphingomyelinase; Short=aSMase; Flags: Precursor [Mus musculus]

Related Sequences to LMP002716 proteins

Reference Database Accession Length Protein Name
GI:6755582 DBBJ BAE28971.1 627 unnamed protein product [Mus musculus]
GI:6755582 DBBJ BAE28406.1 627 unnamed protein product [Mus musculus]
GI:6755582 GenBank AAH11304.1 627 Sphingomyelin phosphodiesterase 1, acid lysosomal [Mus musculus]
GI:6755582 GenBank AAH34515.1 627 Sphingomyelin phosphodiesterase 1, acid lysosomal [Mus musculus]
GI:6755582 GenBank AAH83780.1 627 Sphingomyelin phosphodiesterase 1, acid lysosomal [Rattus norvegicus]
GI:6755582 RefSeq NP_001006998.1 627 sphingomyelin phosphodiesterase [Rattus norvegicus]