Gene/Proteome Database (LMPD)

LMPD ID
LMP002718
Gene ID
29906
Species
Homo sapiens (Human)
Gene Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
Gene Symbol
ST8SIA5
Synonyms
SIAT8E; ST8SiaV
Chromosome
18
Map Location
18q21.1
Summary
The protein encoded by this gene is a type II membrane protein that may be present in the Golgi apparatus. The encoded protein, which is a member of glycosyltransferase family 29, may be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b, and GT3 from GD1a, GT1b, GM1b, and GD3, respectively. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for ST8SIA5

Proteins

alpha-2,8-sialyltransferase 8E
Refseq ID NP_037437
Protein GI 28373101
UniProt ID O15466
mRNA ID NM_013305
Length 376
RefSeq Status REVIEWED
MRYADPSANRDLLGSRTLLFIFICAFALVTLLQQILYGRNYIKRYFEFYEGPFEYNSTRCLELRHEILEVKVLSMVKQSELFDRWKSLQMCKWAMNISEANQFKSTLSRCCNAPAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEKYTMDVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDVSIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVKPRPGFHAMPSEIFNFLHLHSRGILRVHTGTCSCC

Gene Information

Entrez Gene ID
29906
Gene Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
Gene Symbol
ST8SIA5
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0003828 IEA:Ensembl F alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
GO:0006486 IEA:InterPro P protein glycosylation

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_200874 Sialic acid metabolism
REACT_22387 Synthesis of substrates in N-glycan biosythesis

Domain Information

InterPro Annotations

Accession Description
IPR001675 Glycosyl transferase, family 29

UniProt Annotations

Entry Information

Gene Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
Protein Entry
SIA8E_HUMAN
UniProt ID
O15466
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP002718 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
28373101 RefSeq NP_037437 376 alpha-2,8-sialyltransferase 8E

Identical Sequences to LMP002718 proteins

Reference Database Accession Length Protein Name
GI:28373101 DBBJ BAG51661.1 376 unnamed protein product [Homo sapiens]
GI:28373101 EMBL CAS91699.1 376 unnamed protein product [Homo sapiens]
GI:28373101 GenBank AAI08911.1 376 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 [Homo sapiens]
GI:28373101 GenBank EAX01483.1 376 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5, isoform CRA_b [Homo sapiens]
GI:28373101 GenBank AIC51291.1 376 ST8SIA5, partial [synthetic construct]
GI:28373101 SwissProt O15466.2 376 RecName: Full=Alpha-2,8-sialyltransferase 8E; AltName: Full=Sialyltransferase 8E; Short=SIAT8-E; AltName: Full=Sialyltransferase St8Sia V; Short=ST8SiaV [Homo sapiens]

Related Sequences to LMP002718 proteins

Reference Database Accession Length Protein Name
GI:28373101 EMBL CAG26900.1 376 alpha-2,8-sialyltransferase 8E [Pan troglodytes]
GI:28373101 RefSeq NP_001009087.1 376 alpha-2,8-sialyltransferase 8E [Pan troglodytes]
GI:28373101 RefSeq XP_003830235.1 376 PREDICTED: alpha-2,8-sialyltransferase 8E isoform X2 [Pan paniscus]
GI:28373101 RefSeq XP_004059422.1 376 PREDICTED: alpha-2,8-sialyltransferase 8E isoform 1 [Gorilla gorilla gorilla]
GI:28373101 RefSeq XP_006144484.1 376 PREDICTED: alpha-2,8-sialyltransferase 8E isoform X2 [Tupaia chinensis]
GI:28373101 SwissProt P61646.1 376 RecName: Full=Alpha-2,8-sialyltransferase 8E; AltName: Full=Sialyltransferase 8E; Short=SIAT8-E; AltName: Full=Sialyltransferase St8Sia V; Short=ST8SiaV [Pan troglodytes]