Gene/Proteome Database (LMPD)

LMPD ID
LMP002729
Gene ID
15483
Species
Mus musculus (Mouse)
Gene Name
hydroxysteroid 11-beta dehydrogenase 1
Gene Symbol
Hsd11b1
Synonyms
-
Alternate Names
corticosteroid 11-beta-dehydrogenase isozyme 1; 11-DH; 11-beta-HSD1; 11beta-HSD-1; 11beta-HSD1A; 11-beta-hydroxysteroid dehydrogenase 1; 11beta-hydroxysteroid dehydrogenase type 1; Corticosteroid 11-beta-dehydrogenase, isozyme 1 (11-DH) (11-beta-hydroxysteroid dehydrogenase 1) (11-beta-HSD1) (11beta-HSD1A)
Chromosome
1
Map Location
1 H6|1
EC Number
1.1.1.146

Proteins

corticosteroid 11-beta-dehydrogenase isozyme 1
Refseq ID NP_001038216
Protein GI 113680661
UniProt ID P50172
mRNA ID NM_001044751
Length 292
RefSeq Status VALIDATED
MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMIAPYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEECALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN
corticosteroid 11-beta-dehydrogenase isozyme 1
Refseq ID NP_032314
Protein GI 113680741
UniProt ID P50172
mRNA ID NM_008288
Length 292
RefSeq Status VALIDATED
Protein sequence is identical to GI:113680661 (mRNA isoform)

Gene Information

Entrez Gene ID
15483
Gene Name
hydroxysteroid 11-beta dehydrogenase 1
Gene Symbol
Hsd11b1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0070524 IEA:UniProtKB-EC F 11-beta-hydroxysteroid dehydrogenase (NADP+) activity
GO:0003845 IDA:MGI F 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity
GO:0030324 IMP:MGI P lung development
GO:0008202 IEA:UniProtKB-KW P steroid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu05204 Chemical carcinogenesis
mmu00980 Metabolism of xenobiotics by cytochrome P450
mmu00140 Steroid hormone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR020904 Short-chain dehydrogenase/reductase, conserved site

UniProt Annotations

Entry Information

Gene Name
hydroxysteroid 11-beta dehydrogenase 1
Protein Entry
DHI1_MOUSE
UniProt ID
P50172
Species
Mouse

Comments

Comment Type Description
Catalytic Activity An 11-beta-hydroxysteroid + NADP(+) = an 11- oxosteroid + NADPH.
Function Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone.
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Subunit Homodimer. {ECO:0000269|PubMed:15865440}.
Tissue Specificity Widely expressed. Highest expression in liver.

Identical and Related Proteins

Unique RefSeq proteins for LMP002729 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
113680661 RefSeq NP_001038216 292 corticosteroid 11-beta-dehydrogenase isozyme 1

Identical Sequences to LMP002729 proteins

Reference Database Accession Length Protein Name
GI:113680661 GenBank AAI32365.1 292 Hydroxysteroid 11-beta dehydrogenase 1 [Mus musculus]
GI:113680661 GenBank ABP05428.1 292 Sequence 40 from patent US 7176292
GI:113680661 GenBank AAI38781.1 292 Hydroxysteroid 11-beta dehydrogenase 1 [Mus musculus]
GI:113680661 GenBank AAI45416.1 292 Hydroxysteroid 11-beta dehydrogenase 1 [Mus musculus]
GI:113680661 GenBank AFA58275.1 292 Sequence 40 from patent US 8088730
GI:113680661 GenBank AGM58111.1 292 Sequence 4 from patent US 8420365

Related Sequences to LMP002729 proteins

Reference Database Accession Length Protein Name
GI:113680661 GenBank EDL12949.1 334 hydroxysteroid 11-beta dehydrogenase 1, partial [Mus musculus]
GI:113680661 GenBank AGM58112.1 292 Sequence 6 from patent US 8420365
GI:113680661 GenBank AGM58113.1 292 Sequence 8 from patent US 8420365
GI:113680661 GenBank AGM58114.1 292 Sequence 10 from patent US 8420365
GI:113680661 RefSeq XP_006497290.1 333 PREDICTED: corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1 [Mus musculus]
GI:113680661 RefSeq XP_006497291.1 304 PREDICTED: corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X2 [Mus musculus]