Gene/Proteome Database (LMPD)
LMPD ID
LMP002737
Gene ID
Species
Homo sapiens (Human)
Gene Name
estrogen-related receptor beta
Gene Symbol
Synonyms
DFNB35; ERR2; ERRb; ESRL2; NR3B2
Alternate Names
steroid hormone receptor ERR2; ERR-beta; ERRbeta-2; ERR beta-2; nuclear receptor ERRB2; orphan nuclear receptor; estrogen receptor-like 2; estrogen-related nuclear receptor beta; nuclear receptor subfamily 3 group B member 2
Chromosome
14
Map Location
14q24.3
Summary
This gene encodes a protein with similarity to the estrogen receptor. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| steroid hormone receptor ERR2 | |
|---|---|
| Refseq ID | NP_004443 |
| Protein GI | 238550159 |
| UniProt ID | O95718 |
| mRNA ID | NM_004452 |
| Length | 508 |
| RefSeq Status | REVIEWED |
| MSSDDRHLGSSCGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGLALGTHANGLDSPPMFAGAGLGGTPCRKSYEDCASGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKALTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVPMHKLFLEMLEAKVGQEQLRGSPKDERMSSHDGKCPFQSAAFTSRDQSNSPGIPNPRPSSPTPLNERGRQISPSTRTPGGQGKHLWLTM | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005654 | TAS:Reactome | C | nucleoplasm |
| GO:0005634 | ISS:BHF-UCL | C | nucleus |
| GO:0000980 | ISS:BHF-UCL | F | RNA polymerase II distal enhancer sequence-specific DNA binding |
| GO:0004879 | TAS:ProtInc | F | ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity |
| GO:0043565 | IDA:UniProtKB | F | sequence-specific DNA binding |
| GO:0005496 | IEA:InterPro | F | steroid binding |
| GO:0003707 | IEA:InterPro | F | steroid hormone receptor activity |
| GO:0003713 | ISS:BHF-UCL | F | transcription coactivator activity |
| GO:0008134 | ISS:BHF-UCL | F | transcription factor binding |
| GO:0008270 | IEA:InterPro | F | zinc ion binding |
| GO:0010467 | TAS:Reactome | P | gene expression |
| GO:0030522 | TAS:GOC | P | intracellular receptor signaling pathway |
| GO:0045944 | ISS:BHF-UCL | P | positive regulation of transcription from RNA polymerase II promoter |
| GO:0006355 | IDA:UniProtKB | P | regulation of transcription, DNA-templated |
| GO:0019827 | IEA:Ensembl | P | stem cell maintenance |
| GO:0006367 | TAS:Reactome | P | transcription initiation from RNA polymerase II promoter |
| GO:0001834 | IEA:Ensembl | P | trophectodermal cell proliferation |
| GO:0001831 | IEA:Ensembl | P | trophectodermal cellular morphogenesis |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR008946 | Nuclear hormone receptor, ligand-binding |
| IPR000536 | Nuclear hormone receptor, ligand-binding, core |
| IPR024178 | Oestrogen receptor/oestrogen-related receptor |
| IPR027289 | Oestrogen-related receptor |
| IPR001723 | Steroid hormone receptor |
| IPR013088 | Zinc finger, NHR/GATA-type |
| IPR001628 | Zinc finger, nuclear hormone receptor-type |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=ERRbeta2-delta10; IsoId=O95718-1; Sequence=Displayed; Name=2; IsoId=O95718-2; Sequence=VSP_042211; Name=3; Synonyms=ERRbeta-short-form; IsoId=O95718-3; Sequence=VSP_042212; |
| Disease | Deafness, autosomal recessive, 35 (DFNB35) [MIM |
| Function | Nuclear receptor, may regulate ESR1 transcriptional activity. Induces the expression of PERM1 in the skeletal muscle. |
| Ptm | Acetylated by PCAF/KAT2 (in vitro). |
| Similarity | Belongs to the nuclear hormone receptor family. NR3 subfamily. |
| Similarity | Contains 1 nuclear receptor DNA-binding domain. |
| Subcellular Location | Nucleus {ECO |
| Subunit | Binds DNA as a monomer. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002737 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 238550159 | RefSeq | NP_004443 | 508 | steroid hormone receptor ERR2 |
Identical Sequences to LMP002737 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:238550159 | GenBank | AAS15572.1 | 508 | estrogen receptor-related receptor beta2-delta-10 [Homo sapiens] |
| GI:238550159 | GenBank | ADZ17363.1 | 508 | estrogen-related nuclear receptor beta [Homo sapiens] |
| GI:238550159 | SwissProt | O95718.2 | 508 | RecName: Full=Steroid hormone receptor ERR2; AltName: Full=ERR beta-2; AltName: Full=Estrogen receptor-like 2; AltName: Full=Estrogen-related receptor beta; Short=ERR-beta; AltName: Full=Nuclear receptor subfamily 3 group B member 2 [Homo sapiens] |
Related Sequences to LMP002737 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:238550159 | GenBank | AAS15571.1 | 433 | estrogen receptor-related receptor beta short form [Homo sapiens] |
| GI:238550159 | GenBank | AAI31518.1 | 503 | ESRRB protein, partial [Homo sapiens] |
| GI:238550159 | RefSeq | XP_002825009.1 | 508 | PREDICTED: steroid hormone receptor ERR2 isoform X2 [Pongo abelii] |
| GI:238550159 | RefSeq | XP_004055532.1 | 508 | PREDICTED: steroid hormone receptor ERR2 [Gorilla gorilla gorilla] |
| GI:238550159 | RefSeq | XP_006720141.1 | 433 | PREDICTED: steroid hormone receptor ERR2 isoform X4 [Homo sapiens] |
| GI:238550159 | RefSeq | XP_003778394.2 | 529 | PREDICTED: steroid hormone receptor ERR2 isoform X1 [Pongo abelii] |