Gene/Proteome Database (LMPD)
LMPD ID
LMP002739
Gene ID
Species
Homo sapiens (Human)
Gene Name
UDP glucuronosyltransferase 2 family, polypeptide B17
Gene Symbol
Synonyms
BMND12; UDPGT2B17
Alternate Names
UDP-glucuronosyltransferase 2B17; C19-steroid-specific UDPGT; UDP glycosyltransferase 2 family, member B17; UDP-glucuronyltransferase, family 2, beta-17; C19-steroid-specific UDP-glucuronosyltransferase
Chromosome
4
Map Location
4q13
EC Number
2.4.1.17
Summary
This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Copy number variation in this gene is associated with susceptibility to osteoporosis.[provided by RefSeq, Apr 2010]
Orthologs
Proteins
| UDP-glucuronosyltransferase 2B17 precursor | |
|---|---|
| Refseq ID | NP_001068 |
| Protein GI | 4507821 |
| UniProt ID | O75795 |
| mRNA ID | NM_001077 |
| Length | 530 |
| RefSeq Status | REVIEWED |
| MSLKWMSVFLLMQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVIVLTSSASILVNASKSSAIKLEVYPTSLTKNDLEDFFMKMFDRWTYSISKNTFWSYFSQLQELCWEYSDYNIKLCEDAVLNKKLMRKLQESKFDVLLADAVNPCGELLAELLNIPFLYSLRFSVGYTVEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIYMLYFDFWFQAYDLKKWDQFYSEVLGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSSGENGIVVFSLGSMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTMSSRDLLNALKSVINDPIYKENIMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQYHSLDVIAFLLACVATMIFMITKCCLFCFRKLAKTGKKKKRD | |
| sig_peptide: 1..24 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2706 peptide sequence: MSLKWMSVFLLMQLSCYFSSGSCG mat_peptide: 25..530 product: UDP-glucuronosyltransferase 2B17 calculated_mol_wt: 58408 peptide sequence: KVLVWPTEYSHWINMKTILEELVQRGHEVIVLTSSASILVNASKSSAIKLEVYPTSLTKNDLEDFFMKMFDRWTYSISKNTFWSYFSQLQELCWEYSDYNIKLCEDAVLNKKLMRKLQESKFDVLLADAVNPCGELLAELLNIPFLYSLRFSVGYTVEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIYMLYFDFWFQAYDLKKWDQFYSEVLGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSSGENGIVVFSLGSMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTMSSRDLLNALKSVINDPIYKENIMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQYHSLDVIAFLLACVATMIFMITKCCLFCFRKLAKTGKKKKRD | |
Gene Information
Entrez Gene ID
Gene Name
UDP glucuronosyltransferase 2 family, polypeptide B17
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | IEA:UniProtKB-KW | C | endoplasmic reticulum |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0016020 | TAS:ProtInc | C | membrane |
| GO:0015020 | IDA:UniProt | F | glucuronosyltransferase activity |
| GO:0052695 | IDA:UniProt | P | cellular glucuronidation |
| GO:0008202 | TAS:ProtInc | P | steroid metabolic process |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR002213 | UDP-glucuronosyl/UDP-glucosyltransferase |
UniProt Annotations
Entry Information
Gene Name
UDP glucuronosyltransferase 2 family, polypeptide B17
Protein Entry
UDB17_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. |
| Function | UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3-alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT). |
| Polymorphism | Copy-number variation of UGT2B17 defines the bone mineral density quantitative trait locus 12 (BMND12) [MIM |
| Similarity | Belongs to the UDP-glycosyltransferase family. |
| Subcellular Location | Microsome membrane ; Single- pass membrane protein . Endoplasmic reticulum membrane ; Single-pass membrane protein . |
| Tissue Specificity | Expressed in various tissues including the liver, kidney, testis, uterus, placenta, mammary gland, adrenal gland, skin and prostate. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002739 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 4507821 | RefSeq | NP_001068 | 530 | UDP-glucuronosyltransferase 2B17 precursor |
Identical Sequences to LMP002739 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4507821 | GenBank | AAE81110.1 | 530 | Sequence 2 from patent US 6287834 |
| GI:4507821 | GenBank | AAI41518.1 | 530 | UDP glucuronosyltransferase 2 family, polypeptide B17, partial [synthetic construct] |
| GI:4507821 | GenBank | AED39288.1 | 530 | Sequence 1385 from patent US 7883858 |
| GI:4507821 | GenBank | AGU04225.1 | 530 | Sequence 7 from patent US 8476023 |
| GI:4507821 | GenBank | AHD74427.1 | 530 | Sequence 13793 from patent US 8586006 |
| GI:4507821 | SwissProt | O75795.1 | 530 | RecName: Full=UDP-glucuronosyltransferase 2B17; Short=UDPGT 2B17; AltName: Full=C19-steroid-specific UDP-glucuronosyltransferase; Short=C19-steroid-specific UDPGT; Flags: Precursor [Homo sapiens] |
Related Sequences to LMP002739 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4507821 | GenBank | AAB28536.1 | 530 | dihydrotestosterone/androstanediol UDP-glucuronosyltransferase isoform 3, udpgth-3 [Homo sapiens] |
| GI:4507821 | GenBank | AAC50077.1 | 530 | UDP glucuronosyltransferase precursor [Homo sapiens] |
| GI:4507821 | GenBank | AAN40695.1 | 530 | UDP-glucuronosyltransferase [Homo sapiens] |
| GI:4507821 | GenBank | AAQ46847.1 | 530 | Sequence 113 from patent US 6586175 |
| GI:4507821 | GenBank | ADR85261.1 | 530 | Sequence 12 from patent US 7736853 |
| GI:4507821 | RefSeq | XP_001163237.1 | 530 | PREDICTED: UDP-glucuronosyltransferase 2B17 [Pan troglodytes] |