Gene/Proteome Database (LMPD)

LMPD ID
LMP002740
Gene ID
64781
Species
Homo sapiens (Human)
Gene Name
ceramide kinase
Gene Symbol
CERK
Synonyms
LK4; dA59H18.2; dA59H18.3; hCERK
Alternate Names
ceramide kinase; lipid kinase 4; lipid kinase LK4; acylsphingosine kinase
Chromosome
22
Map Location
22q13.31
EC Number
2.7.1.138
Summary
CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008]
Orthologs
View orthologs and multiple alignments for CERK

Proteins

ceramide kinase
Refseq ID NP_073603
Protein GI 20336726
UniProt ID Q8TCT0
mRNA ID NM_022766
Length 537
RefSeq Status VALIDATED
MGATGAAEPLQSVLWVKQQRCAVSLEPARALLRWWRSPGPGAGAPGADACSVPVSEIIAVEETDVHGKHQGSGKWQKMEKPYAFTVHCVKRARRHRWKWAQVTFWCPEEQLCHLWLQTLREMLEKLTSRPKHLLVFINPFGGKGQGKRIYERKVAPLFTLASITTDIIVTEHANQAKETLYEINIDKYDGIVCVGGDGMFSEVLHGLIGRTQRSAGVDQNHPRAVLVPSSLRIGIIPAGSTDCVCYSTVGTSDAETSALHIVVGDSLAMDVSSVHHNSTLLRYSVSLLGYGFYGDIIKDSEKKRWLGLARYDFSGLKTFLSHHCYEGTVSFLPAQHTVGSPRDRKPCRAGCFVCRQSKQQLEEEQKKALYGLEAAEDVEEWQVVCGKFLAINATNMSCACRRSPRGLSPAAHLGDGSSDLILIRKCSRFNFLRFLIRHTNQQDQFDFTFVEVYRVKKFQFTSKHMEDEDSDLKEGGKKRFGHICSSHPSCCCTVSNSSWNCDGEVLHSPAIEVRVHCQLVRLFARGIEENPKPDSHS

Gene Information

Entrez Gene ID
64781
Gene Name
ceramide kinase
Gene Symbol
CERK
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IDA:UniProtKB C integral component of membrane
GO:0005739 IEA:Ensembl C mitochondrion
GO:0005886 TAS:Reactome C plasma membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0003951 IEA:InterPro F NAD+ kinase activity
GO:0001729 IDA:UniProtKB F ceramide kinase activity
GO:0004143 IEA:InterPro F diacylglycerol kinase activity
GO:0000287 IDA:UniProtKB F magnesium ion binding
GO:0006672 IDA:UniProtKB P ceramide metabolic process
GO:0006687 TAS:Reactome P glycosphingolipid metabolic process
GO:0046834 IDA:GOC P lipid phosphorylation
GO:0007205 IEA:InterPro P protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0006665 TAS:Reactome P sphingolipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00600 Sphingolipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_116105 Glycosphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR016064 ATP-NAD kinase-like domain
IPR001206 Diacylglycerol kinase, catalytic domain
IPR001849 Pleckstrin homology domain

UniProt Annotations

Entry Information

Gene Name
ceramide kinase
Protein Entry
CERK1_HUMAN
UniProt ID
Q8TCT0
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8TCT0-1; Sequence=Displayed; Name=2; IsoId=Q8TCT0-2; Sequence=VSP_056944; Note=No experimental confirmation available;
Biophysicochemical Properties pH dependence: Optimum pH is 6.0-7.5.;
Catalytic Activity ATP + ceramide = ADP + ceramide 1-phosphate.
Cofactor Name=Ca(2+); Xref=ChEBI
Cofactor Name=Mg(2+); Xref=ChEBI
Enzyme Regulation Inhibited by sulfatide.
Function Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides.
Similarity Contains 1 DAGKc domain. {ECO
Subcellular Location Cytoplasm . Membrane ; Peripheral membrane protein .
Tissue Specificity High level expression in heart, brain, skeletal muscle, kidney and liver; moderate in peripheral blood leukocytes and thymus; very low in spleen, small intestine, placenta and lung.

Identical and Related Proteins

Unique RefSeq proteins for LMP002740 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
20336726 RefSeq NP_073603 537 ceramide kinase

Identical Sequences to LMP002740 proteins

Reference Database Accession Length Protein Name
GI:20336726 DBBJ BAF84165.1 537 unnamed protein product [Homo sapiens]
GI:20336726 DBBJ BAG72490.1 537 ceramide kinase, partial [synthetic construct]
GI:20336726 EMBL CAK54679.1 537 CERK, partial [synthetic construct]
GI:20336726 GenBank AAI26941.1 537 Ceramide kinase [Homo sapiens]
GI:20336726 GenBank EAW73439.1 537 ceramide kinase, isoform CRA_b [Homo sapiens]
GI:20336726 GenBank EAW73441.1 537 ceramide kinase, isoform CRA_b [Homo sapiens]

Related Sequences to LMP002740 proteins

Reference Database Accession Length Protein Name
GI:20336726 GenBank JAA13843.1 537 ceramide kinase [Pan troglodytes]
GI:20336726 GenBank JAA13844.1 537 ceramide kinase [Pan troglodytes]
GI:20336726 GenBank JAA13845.1 537 ceramide kinase [Pan troglodytes]
GI:20336726 GenBank JAA13846.1 537 ceramide kinase [Pan troglodytes]
GI:20336726 GenBank JAA13847.1 537 ceramide kinase [Pan troglodytes]
GI:20336726 GenBank JAA13848.1 537 ceramide kinase [Pan troglodytes]