Gene/Proteome Database (LMPD)
LMPD ID
LMP002761
Gene ID
Species
Mus musculus (Mouse)
Gene Name
galactose-3-O-sulfotransferase 1
Gene Symbol
Synonyms
Cst; Gcst
Alternate Names
galactosylceramide sulfotransferase; Galcer sulfotransferase; cerebroside sulfotransferase', "3'-phosphoadenosine-5'-phosphosulfate:Galcer sulfotransferase", "3'-phosphoadenylylsulfate-galactosylceramide 3'-sulfotransferase
Chromosome
11
Map Location
11 A1|11
EC Number
2.8.2.11
Proteins
| galactosylceramide sulfotransferase | |
|---|---|
| Refseq ID | NP_001171162 |
| Protein GI | 295148064 |
| UniProt ID | Q9JHE4 |
| mRNA ID | NM_001177691 |
| Length | 423 |
| RefSeq Status | VALIDATED |
| MTLLPKKPCKSKAKGLLLGALFTSFLLLLYSYVVPPLYPNMAFTTSEAAAPCSPIPNEPVAATPANGSAGGCQPRRDIVFMKTHKTASSTLLNILFRFGQKHELKFAFPNGRNDFHYPSYFARSLVQDYRPGACFNIICNHMRFHYEEVRGLVRPGATFITVIRDPARLFESSFHYFGSVVPLTWKLSSRDKLAEFLQDPDRYYDPSSYNAHYLRNLLFFDLGYDSSLDPASPRVQEHILEVERRFHLVLLQEYFDESLVLLRELLCWDLEDVLYFKLNARRDSPVPRLSGELYRRATAWNLLDVRLYRHFNASFWRKVEAFGRERMAREVAELRQANEHMRHICIDGGQAVGAEAIQDSAMQPWQPLGIKSILGYNLKKSIGPQHEQLCRRMLTPEIQYLSDLGANLWVTKLWKFLRDFLRW | |
| galactosylceramide sulfotransferase | |
|---|---|
| Refseq ID | NP_058618 |
| Protein GI | 31980855 |
| UniProt ID | Q9JHE4 |
| mRNA ID | NM_016922 |
| Length | 423 |
| RefSeq Status | VALIDATED |
| Protein sequence is identical to GI:295148064 (mRNA isoform) | |
| galactosylceramide sulfotransferase | |
|---|---|
| Refseq ID | NP_001171174 |
| Protein GI | 295148114 |
| UniProt ID | Q9JHE4 |
| mRNA ID | NM_001177703 |
| Length | 423 |
| RefSeq Status | VALIDATED |
| Protein sequence is identical to GI:295148064 (mRNA isoform) | |
Gene Information
Entrez Gene ID
Gene Name
galactose-3-O-sulfotransferase 1
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0000139 | TAS:MGI | C | Golgi membrane |
| GO:0016021 | ISS:MGI | C | integral component of membrane |
| GO:0001733 | IDA:MGI | F | galactosylceramide sulfotransferase activity |
| GO:0006682 | IDA:MGI | P | galactosylceramide biosynthetic process |
| GO:0009247 | TAS:MGI | P | glycolipid biosynthetic process |
| GO:0042552 | IMP:MGI | P | myelination |
| GO:0007283 | IMP:MGI | P | spermatogenesis |
KEGG Pathway Links
Domain Information
UniProt Annotations
Entry Information
Gene Name
galactose-3-O-sulfotransferase 1
Protein Entry
G3ST1_MOUSE
UniProt ID
Species
Mouse
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | 3'-phosphoadenylyl sulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate. |
| Catalytic Activity | 3'-phosphoadenylyl sulfate + monogalactosylalkylacylglycerol = adenosine 3',5'-bisphosphate + monogalactosylalkylacylglycerol sulfate. |
| Function | Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of HSO3-3-galactosylceramide (sulfatide), a major lipid component of the myelin sheath and of HSO3-3-monogalactosylalkylacylglycerol (seminolipid), present in spermatocytes. Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro). {ECO:0000269|PubMed:11917099}. |
| Miscellaneous | Mice homozygous for a null mutation of the CST gene display hindlimb weakness from week 6 of age and subsequently show a prenounced tremor and progressive ataxia. Myelin vacuolation is observed in the cerebellar white matter, diencephalon, brainstem and spinal anterior column. Male mice were infertile due to a blocked spermatogenesis. |
| Pathway | Lipid metabolism; sphingolipid metabolism. |
| Similarity | Belongs to the galactose-3-O-sulfotransferase family. {ECO:0000305}. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Tissue Specificity | Expressed in brain, testis, kidney, stomach, small intestine, liver, and lung. Not detected in heart, skeletal muscle, and spleen. {ECO:0000269|PubMed:10727929}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002761 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 295148064 | RefSeq | NP_001171162 | 423 | galactosylceramide sulfotransferase |
Identical Sequences to LMP002761 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:295148064 | GenBank | AAH26806.1 | 423 | Galactose-3-O-sulfotransferase 1 [Mus musculus] |
| GI:295148064 | GenBank | EDL40451.1 | 423 | galactose-3-O-sulfotransferase 1 [Mus musculus] |
| GI:295148064 | RefSeq | NP_058618.2 | 423 | galactosylceramide sulfotransferase [Mus musculus] |
| GI:295148064 | RefSeq | NP_001171174.1 | 423 | galactosylceramide sulfotransferase [Mus musculus] |
| GI:295148064 | RefSeq | XP_006514820.1 | 423 | PREDICTED: galactosylceramide sulfotransferase isoform X2 [Mus musculus] |
| GI:295148064 | SwissProt | Q9JHE4.2 | 423 | RecName: Full=Galactosylceramide sulfotransferase; Short=GalCer sulfotransferase; AltName: Full=3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase; AltName: Full=3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase; AltName: Full=Cerebroside sulfotransferase [Mus musculus] |
Related Sequences to LMP002761 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:295148064 | DBBJ | BAA93008.1 | 423 | cerebroside sulfotransferase [Mus musculus] |
| GI:295148064 | DBBJ | BAA93009.1 | 423 | cerebroside sulfotransferase [Mus musculus] |
| GI:295148064 | DBBJ | BAB25160.1 | 423 | unnamed protein product [Mus musculus] |
| GI:295148064 | GenBank | EDM00205.1 | 423 | rCG35695, isoform CRA_b [Rattus norvegicus] |
| GI:295148064 | RefSeq | XP_006514819.1 | 454 | PREDICTED: galactosylceramide sulfotransferase isoform X1 [Mus musculus] |
| GI:295148064 | RefSeq | XP_008768587.1 | 423 | PREDICTED: galactosylceramide sulfotransferase isoform X2 [Rattus norvegicus] |