Gene/Proteome Database (LMPD)
LMPD ID
LMP002766
Gene ID
Species
Homo sapiens (Human)
Gene Name
lysophosphatidic acid receptor 2
Gene Symbol
Synonyms
EDG-4; EDG4; LPA-2; LPA2
Alternate Names
lysophosphatidic acid receptor 2; LPA receptor 2; LPA receptor EDG4; G protein-coupled receptor; lysophosphatidic acid receptor EDG4; lysophosphatidic acid receptor Edg-4; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4
Chromosome
19
Map Location
19p12
Summary
This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| lysophosphatidic acid receptor 2 | |
|---|---|
| Refseq ID | NP_004711 |
| Protein GI | 7305013 |
| UniProt ID | Q9HBW0 |
| mRNA ID | NM_004720 |
| Length | 351 |
| RefSeq Status | REVIEWED |
| MVIMGQCYYNETIGFFYNNSGKELSSHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWFLRQGLLDTSLTASVATLLAIAVERHRSVMAVQLHSRLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMAEHVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLLDGLGCESCNVLAVEKYFLLLAEANSLVNAAVYSCRDAEMRRTFRRLLCCACLRQSTRESVHYTSSAQGGASTRIMLPENGHPLMDSTL | |
Gene Information
Entrez Gene ID
Gene Name
lysophosphatidic acid receptor 2
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0009986 | IDA:UniProtKB | C | cell surface |
| GO:0005887 | TAS:ProtInc | C | integral component of plasma membrane |
| GO:0005886 | TAS:Reactome | C | plasma membrane |
| GO:0004930 | TAS:ProtInc | F | G-protein coupled receptor activity |
| GO:0008289 | TAS:ProtInc | F | lipid binding |
| GO:0070915 | IEA:InterPro | F | lysophosphatidic acid receptor activity |
| GO:0000187 | IEA:Ensembl | P | activation of MAPK activity |
| GO:0007202 | TAS:ProtInc | P | activation of phospholipase C activity |
| GO:0007186 | TAS:ProtInc | P | G-protein coupled receptor signaling pathway |
| GO:0007204 | TAS:ProtInc | P | positive regulation of cytosolic calcium ion concentration |
| GO:0035025 | IEA:Ensembl | P | positive regulation of Rho protein signal transduction |
KEGG Pathway Links
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_19231 | G alpha (i) signalling events |
| REACT_18365 | Lysosphingolipid and LPA receptors |
Domain Information
UniProt Annotations
Entry Information
Gene Name
lysophosphatidic acid receptor 2
Protein Entry
LPAR2_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Function | Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation. {ECO |
| Interaction | P13569:CFTR; NbExp=3; IntAct=EBI-765995, EBI-349854; Q15599:SLC9A3R2; NbExp=3; IntAct=EBI-765995, EBI-1149760; |
| Miscellaneous | PubMed:9525886 cDNA clone has a guanine nucleotide deletion that causes a frameshift near its C-terminal coding region. This likely reflects a somatic mutation in the ovary tumor cells from which the cDNA was isolated and may have altered the function of the encoded receptor, and contributed to transformation of the original ovary cells that formed a tumor. |
| Sequence Caution | Sequence=AAC27728.1; Type=Frameshift; Positions=348; Evidence= ; |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Subcellular Location | Cell surface . Cell membrane ; Multi-pass membrane protein . Note=Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles. |
| Subunit | Interacts with SLC9A3R2/NHERF2, MAGI3 and PLCB3. Interacts with RALA and ADRBK1. {ECO |
| Tissue Specificity | Expressed most abundantly in testes and peripheral blood leukocytes with less expression in pancreas, spleen, thymus and prostate. Little or no expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney, ovary, small intestine, or colon. |
| Web Resource | Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/LPAR2ID40406ch19p13.html"; |
Identical and Related Proteins
Unique RefSeq proteins for LMP002766 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 7305013 | RefSeq | NP_004711 | 351 | lysophosphatidic acid receptor 2 |
Identical Sequences to LMP002766 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:7305013 | EMBL | CCV20022.1 | 351 | unnamed protein product [Homo sapiens] |
| GI:7305013 | GenBank | ACR85431.1 | 351 | Sequence 8 from patent US 7521192 |
| GI:7305013 | GenBank | AEH98557.1 | 351 | Sequence 4 from patent US 7947665 |
| GI:7305013 | GenBank | AIC50288.1 | 351 | LPAR2, partial [synthetic construct] |
| GI:7305013 | RefSeq | XP_004060431.1 | 351 | PREDICTED: lysophosphatidic acid receptor 2 isoform 1 [Gorilla gorilla gorilla] |
| GI:7305013 | RefSeq | XP_004060432.1 | 351 | PREDICTED: lysophosphatidic acid receptor 2 isoform 2 [Gorilla gorilla gorilla] |
Related Sequences to LMP002766 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:7305013 | GenBank | AAG28521.1 | 351 | lysophosphatidic acid receptor EDG4 [Homo sapiens] |
| GI:7305013 | GenBank | AAN99230.1 | 352 | Sequence 13 from patent US 6482609 |
| GI:7305013 | GenBank | AAV38266.1 | 352 | endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4, partial [synthetic construct] |
| GI:7305013 | GenBank | AAV38267.1 | 352 | endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4, partial [synthetic construct] |
| GI:7305013 | GenBank | AAX43075.1 | 352 | endothelial differentiation lysophosphatidic acid G-protein-coupled receptor 4, partial [synthetic construct] |
| GI:7305013 | GenBank | AAX43076.1 | 352 | endothelial differentiation lysophosphatidic acid G-protein-coupled receptor 4, partial [synthetic construct] |