Gene/Proteome Database (LMPD)
LMPD ID
LMP002768
Gene ID
Species
Homo sapiens (Human)
Gene Name
acyl-CoA thioesterase 2
Gene Symbol
Synonyms
CTE-IA; CTE1A; MTE1; PTE2; PTE2A; ZAP128
Alternate Names
acyl-coenzyme A thioesterase 2, mitochondrial; long-chain acyl-CoA thioesterase 2; mitochondrial acyl-CoA thioesterase 1; acyl-coenzyme A thioester hydrolase 2a; peroxisomal long-chain acyl-coA thioesterase 2
Chromosome
14
Map Location
14q24.3
EC Number
3.1.2.2
Summary
This gene encodes a member of the acyl-CoA thioesterase protein family, and is one of four acyl-CoA hydrolase genes located in a cluster on chromosome 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Orthologs
Proteins
| acyl-coenzyme A thioesterase 2, mitochondrial | |
|---|---|
| Refseq ID | NP_006812 |
| Protein GI | 148727286 |
| UniProt ID | P49753 |
| mRNA ID | NM_006821 |
| Length | 483 |
| RefSeq Status | VALIDATED |
| MSNKLLSPHPHSVVLRSEFKMASSPAVLRASRLYQWSLKSSAQFLGSPQLRQVGQIIRVPARMAATLILEPAGRCCWDEPVRIAVRGLAPEQPVTLRASLRDEKGALFQAHARYRADTLGELDLERAPALGGSFAGLEPMGLLWALEPEKPLVRLVKRDVRTPLAVELEVLDGHDPDPGRLLCQTRHERYFLPPGVRREPVRVGRVRGTLFLPPEPGPFPGIVDMFGTGGGLLEYRASLLAGKGFAVMALAYYNYEDLPKTMETLHLEYFEEAMNYLLSHPEVKGPGVGLLGISKGGELCLSMASFLKGITAAVVINGSVANVGGTLHYKGETLPPVGVNRNRIKVTKDGYADIVDVLNSPLEGPDQKSFIPVERAESTFLFLVGQDDHNWKSEFYANEACKRLQAHGRRKPQIICYPETGHYIEPPYFPLCRASLHALVGSPIIWGGEPRAHAMAQVDAWKQLQTFFHKHLGGHEGTIPSKV | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0070062 | IDA:UniProt | C | extracellular vesicular exosome |
| GO:0005739 | IDA:HGNC | C | mitochondrion |
| GO:0047617 | IDA:HGNC | F | acyl-CoA hydrolase activity |
| GO:0052689 | IEA:UniProtKB-KW | F | carboxylic ester hydrolase activity |
| GO:0016290 | IEA:UniProtKB-EC | F | palmitoyl-CoA hydrolase activity |
| GO:0005102 | IPI:UniProtKB | F | receptor binding |
| GO:0006637 | IDA:HGNC | P | acyl-CoA metabolic process |
| GO:0001676 | IDA:HGNC | P | long-chain fatty acid metabolic process |
| GO:0000038 | IDA:HGNC | P | very long-chain fatty acid metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa01040 | Biosynthesis of unsaturated fatty acids |
| hsa04913 | Ovarian steroidogenesis |
BIOCYC Pathway Links
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P49753-1; Sequence=Displayed; Name=2; IsoId=P49753-2; Sequence=VSP_012225, VSP_012226; |
| Biophysicochemical Properties | Kinetic parameters: KM=40.3 uM for C10-acyl-CoA ; KM=8.9 uM for C12-acyl-CoA ; KM=1.6 uM for C14-acyl-CoA ; KM=2.0 uM for C16-acyl-CoA ; KM=2.8 uM for C18-acyl-CoA ; KM=4.8 uM for C20-acyl-CoA ; KM=4.5 uM for C16:1-acyl-CoA ; KM=6.1 uM for C18:1-acyl-CoA ; KM=4.3 uM for C18:1-trans-acyl-CoA ; Vmax=212 nmol/min/mg enzyme toward C10-acyl-CoA ; Vmax=681 nmol/min/mg enzyme toward C12-acyl-CoA ; Vmax=766 nmol/min/mg enzyme toward C14-acyl-CoA ; Vmax=656 nmol/min/mg enzyme toward C16-acyl-CoA ; Vmax=488 nmol/min/mg enzyme toward C18-acyl-CoA ; Vmax=408 nmol/min/mg enzyme toward C20-acyl-CoA ; Vmax=661 nmol/min/mg enzyme toward C16:1-acyl-CoA ; Vmax=304 nmol/min/mg enzyme toward C18:1-acyl-CoA ; Vmax=418 nmol/min/mg enzyme toward C18:1-trans-acyl-CoA ; |
| Catalytic Activity | Palmitoyl-CoA + H(2)O = CoA + palmitate. |
| Caution | Was originally (PubMed:10944470) thought to be peroxisomal but was later shown (PubMed:16940157) to be mitochondrial. {ECO |
| Function | Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs. |
| Sequence Caution | Sequence=AAC42007.1; Type=Frameshift; Positions=215, 226; Evidence= ; |
| Similarity | Belongs to the C/M/P thioester hydrolase family. |
| Subcellular Location | Mitochondrion . |
| Tissue Specificity | Strongest expression in heart, liver, muscle and kidney. Weak in placenta and pancreas. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002768 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 148727286 | RefSeq | NP_006812 | 483 | acyl-coenzyme A thioesterase 2, mitochondrial |
Identical Sequences to LMP002768 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:148727286 | SwissProt | P49753.6 | 483 | RecName: Full=Acyl-coenzyme A thioesterase 2, mitochondrial; Short=Acyl-CoA thioesterase 2; AltName: Full=Acyl-coenzyme A thioester hydrolase 2a; AltName: Full=CTE-Ia; AltName: Full=Long-chain acyl-CoA thioesterase 2; AltName: Full=ZAP128; Flags: Precursor [Homo sapiens] |
Related Sequences to LMP002768 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:148727286 | DBBJ | BAD97355.1 | 483 | peroxisomal long-chain acyl-coA thioesterase variant, partial [Homo sapiens] |
| GI:148727286 | GenBank | AAH06335.1 | 483 | Acyl-CoA thioesterase 2 [Homo sapiens] |
| GI:148727286 | GenBank | AAZ31237.1 | 483 | mitochondrial acyl-CoA thioesterase 2 [Homo sapiens] |
| GI:148727286 | GenBank | EAW81118.1 | 483 | hCG21524, isoform CRA_a [Homo sapiens] |
| GI:148727286 | GenBank | ABM84414.1 | 483 | acyl-CoA thioesterase 2 [synthetic construct] |
| GI:148727286 | GenBank | ABM87405.1 | 483 | acyl-CoA thioesterase 2, partial [synthetic construct] |