Gene/Proteome Database (LMPD)
LMPD ID
LMP002770
Gene ID
Species
Homo sapiens (Human)
Gene Name
sulfotransferase family, cytosolic, 2B, member 1
Gene Symbol
Synonyms
HSST2
Alternate Names
sulfotransferase family cytosolic 2B member 1; ST2B1; sulfotransferase 2B1; alcohol sulfotransferase; hydroxysteroid sulfotransferase 2
Chromosome
19
Map Location
19q13.3
EC Number
2.8.2.2
Summary
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| sulfotransferase family cytosolic 2B member 1 isoform a | |
|---|---|
| Refseq ID | NP_004596 |
| Protein GI | 31563388 |
| UniProt ID | O00204 |
| mRNA ID | NM_004605 |
| Length | 350 |
| RefSeq Status | REVIEWED |
| MASPPPFHSQKLPGEYFRYKGVPFPVGLYSLESISLAENTQDVRDDDIFIITYPKSGTTWMIEIICLILKEGDPSWIRSVPIWERAPWCETIVGAFSLPDQYSPRLMSSHLPIQIFTKAFFSSKAKVIYMGRNPRDVVVSLYHYSKIAGQLKDPGTPDQFLRDFLKGEVQFGSWFDHIKGWLRMKGKDNFLFITYEELQQDLQGSVERICGFLGRPLGKEALGSVVAHSTFSAMKANTMSNYTLLPPSLLDHRRGAFLRKGVCGDWKNHFTVAQSEAFDRAYRKQMRGMPTFPWDEDPEEDGSPDPEPSPEPEPKPSLEPNTSLEREPRPNSSPSPSPGQASETPHPRPS | |
| sulfotransferase family cytosolic 2B member 1 isoform b | |
|---|---|
| Refseq ID | NP_814444 |
| Protein GI | 31563386 |
| UniProt ID | O00204 |
| mRNA ID | NM_177973 |
| Length | 365 |
| RefSeq Status | REVIEWED |
| MDGPAEPQIPGLWDTYEDDISEISQKLPGEYFRYKGVPFPVGLYSLESISLAENTQDVRDDDIFIITYPKSGTTWMIEIICLILKEGDPSWIRSVPIWERAPWCETIVGAFSLPDQYSPRLMSSHLPIQIFTKAFFSSKAKVIYMGRNPRDVVVSLYHYSKIAGQLKDPGTPDQFLRDFLKGEVQFGSWFDHIKGWLRMKGKDNFLFITYEELQQDLQGSVERICGFLGRPLGKEALGSVVAHSTFSAMKANTMSNYTLLPPSLLDHRRGAFLRKGVCGDWKNHFTVAQSEAFDRAYRKQMRGMPTFPWDEDPEEDGSPDPEPSPEPEPKPSLEPNTSLEREPRPNSSPSPSPGQASETPHPRPS | |
Gene Information
Entrez Gene ID
Gene Name
sulfotransferase family, cytosolic, 2B, member 1
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | IDA:HPA | C | cytoplasm |
| GO:0005829 | TAS:Reactome | C | cytosol |
| GO:0005783 | IEA:UniProtKB-KW | C | endoplasmic reticulum |
| GO:0070062 | IDA:UniProtKB | C | extracellular vesicular exosome |
| GO:0043231 | IDA:HPA | C | intracellular membrane-bounded organelle |
| GO:0005634 | IEA:UniProtKB-KW | C | nucleus |
| GO:0004027 | TAS:Reactome | F | alcohol sulfotransferase activity |
| GO:0050294 | IDA:UniProtKB | F | steroid sulfotransferase activity |
| GO:0050427 | TAS:Reactome | P | 3'-phosphoadenosine 5'-phosphosulfate metabolic process |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
| GO:0008202 | IDA:UniProtKB | P | steroid metabolic process |
| GO:0000103 | IEA:Ensembl | P | sulfate assimilation |
| GO:0006805 | TAS:Reactome | P | xenobiotic metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa00140 | Steroid hormone biosynthesis |
Domain Information
UniProt Annotations
Entry Information
Gene Name
sulfotransferase family, cytosolic, 2B, member 1
Protein Entry
ST2B1_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=SULT2B1b, B; IsoId=O00204-1; Sequence=Displayed; Name=2; Synonyms=SULT2B1a, A; IsoId=O00204-2; Sequence=VSP_012510; |
| Biophysicochemical Properties | Kinetic parameters: KM=10.9 uM for DHEA (at 37 degrees Celsius, in the presence of 1mM MgCl2) {ECO |
| Catalytic Activity | 3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate. |
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol. {ECO |
| Interaction | Q96Q35:ALS2CR12; NbExp=3; IntAct=EBI-749441, EBI-750451; |
| Similarity | Belongs to the sulfotransferase 1 family. |
| Subcellular Location | Cytoplasm. Microsome. Nucleus. Note=Phosphorylation of Ser-348 is required for translocation to the nucleus. |
| Tissue Specificity | Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002770 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 31563388 | RefSeq | NP_004596 | 350 | sulfotransferase family cytosolic 2B member 1 isoform a |
| 31563386 | RefSeq | NP_814444 | 365 | sulfotransferase family cytosolic 2B member 1 isoform b |
Identical Sequences to LMP002770 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:31563388 | GenBank | AAC78553.1 | 350 | hydroxysteroid sulfotransferase SULT2B1a [Homo sapiens] |
| GI:31563386 | GenBank | EAW52354.1 | 365 | sulfotransferase family, cytosolic, 2B, member 1, isoform CRA_a [Homo sapiens] |
| GI:31563388 | GenBank | EAW52355.1 | 350 | sulfotransferase family, cytosolic, 2B, member 1, isoform CRA_b [Homo sapiens] |
| GI:31563386 | GenBank | ABY19167.1 | 365 | Sequence 18 from patent US 7288642 |
| GI:31563386 | GenBank | ADQ32321.1 | 365 | sulfotransferase family, cytosolic, 2B, member 1, partial [synthetic construct] |
| GI:31563386 | GenBank | ADS87300.1 | 365 | Sequence 18 from patent US 7820805 |
| GI:31563388 | GenBank | AHD78260.1 | 350 | Sequence 25597 from patent US 8586006 |
| GI:31563386 | GenBank | AHD78261.1 | 365 | Sequence 25598 from patent US 8586006 |
| GI:31563388 | PDB | 1Q1Q | 350 | Chain A, Crystal Structure Of Human Pregnenolone Sulfotransferase (Sult2b1a) In The Presence Of Pap |
| GI:31563386 | SwissProt | O00204.2 | 365 | RecName: Full=Sulfotransferase family cytosolic 2B member 1; Short=ST2B1; Short=Sulfotransferase 2B1; AltName: Full=Alcohol sulfotransferase; AltName: Full=Hydroxysteroid sulfotransferase 2 [Homo sapiens] |
Related Sequences to LMP002770 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:31563388 | GenBank | AAC78498.1 | 350 | hydroxysteroid sulfotransferase SULT2B1a [Homo sapiens] |
| GI:31563388 | GenBank | ABY19166.1 | 350 | Sequence 16 from patent US 7288642 |
| GI:31563388 | GenBank | ABY19167.1 | 365 | Sequence 18 from patent US 7288642 |
| GI:31563388 | GenBank | ACM81028.1 | 350 | Sequence 6526 from patent US 6812339 |
| GI:31563388 | GenBank | ACM85713.1 | 377 | Sequence 11211 from patent US 6812339 |
| GI:31563388 | GenBank | ADS87299.1 | 350 | Sequence 16 from patent US 7820805 |
| GI:31563386 | GenBank | EHH59748.1 | 363 | hypothetical protein EGM_09935 [Macaca fascicularis] |
| GI:31563386 | GenBank | AIC62034.1 | 366 | SULT2B1, partial [synthetic construct] |
| GI:31563386 | RefSeq | XP_001171142.1 | 365 | PREDICTED: sulfotransferase family cytosolic 2B member 1 [Pan troglodytes] |
| GI:31563386 | RefSeq | XP_003814133.1 | 365 | PREDICTED: sulfotransferase family cytosolic 2B member 1 [Pan paniscus] |
| GI:31563386 | RefSeq | XP_003915884.1 | 363 | PREDICTED: sulfotransferase family cytosolic 2B member 1 [Papio anubis] |
| GI:31563386 | RefSeq | XP_010366958.1 | 364 | PREDICTED: sulfotransferase family cytosolic 2B member 1 [Rhinopithecus roxellana] |