Gene/Proteome Database (LMPD)
LMPD ID
LMP002774
Gene ID
Species
Mus musculus (Mouse)
Gene Name
carnitine palmitoyltransferase 1c
Gene Symbol
Synonyms
6530437J22Rik; 9630004I06Rik
Alternate Names
carnitine O-palmitoyltransferase 1, brain isoform; CPT IC; CPT1-B; CPTI-B; CPT I-C; carnitine palmitoyltransferase 1, brain; carnitine O-palmitoyltransferase I, brain isoform
Chromosome
7
Map Location
7 B2|7
EC Number
2.3.1.21
Proteins
| carnitine O-palmitoyltransferase 1, brain isoform | |
|---|---|
| Refseq ID | NP_710146 |
| Protein GI | 24211027 |
| UniProt ID | Q8BGD5 |
| mRNA ID | NM_153679 |
| Length | 798 |
| RefSeq Status | VALIDATED |
| MAEAHQASSLLSSLSSDGAEVELSSPVWQEIYLCALRSWKRHLWRVWNDFLAGVVPATPLSWLFLFSTIQLACLLQLDPSLGLMEKIKELLPDWGGQHHQLQGFLSAAVFASCLWGALIFTLHVALRLLLSHHGWLLEPHGAMSSPTKTWLALVRIFSGRHPRLFSFQRALPRQPVPSAQETVRKYLESVRPVLGDDAFDRATALANDFLRLHAPRLQLYLQLKSWCTSNYVSDWWEEFVYLRSRGSLINSTYYMMDFLYVTPTPLQAARAGNAVHTLLLYRHLLNRQEISPTLLMGMRPLCSAQYERMFNTTRIPGVEKDHLRHLQDSRHVAVFHRGRFFRVGTHSPNGLLSPRALEQQFQDILDDPSPACPLEEHLAALTAAPRSMWAQVRESVKTHAATALEAVEGAAFFVSLDSEPAGLTREDPAASLDAYAHALLAGRGHDRWFDKSFTLIVFSNGKLGLSVEHSWADCPVSGHLWEFTLATECFQLGYATDGHCKGHPDPTLPQPQRLQWDLPEQIQPSISLALRGAKTLSGNIDCHVFPFSHFGKSFIKCCHVSSDSFIQLVLQLAHFRDRGQFCLTYESAMTRLFLEGRTETVRSCTREACQFVRAMDNKETDQHCLALFRVAVDKHQALLKAAMSGQGIDRHLFALYIMSRLLHMQSPFLTQVQSQQWLLSTSQVPVQQTHLIDVHNYPDYVSSGGGFGPAHDHGYGISYIFMGENAITFHISSKKSSTETDSHRLGQHIENALLDVASLFRVGQHFKRQFRGENSDYRYNFLSCKTVDPNTPTSSTNL | |
| carnitine O-palmitoyltransferase 1, brain isoform | |
|---|---|
| Refseq ID | NP_001239399 |
| Protein GI | 357197142 |
| UniProt ID | Q8BGD5 |
| mRNA ID | NM_001252470 |
| Length | 798 |
| RefSeq Status | VALIDATED |
| Protein sequence is identical to GI:24211027 (mRNA isoform) | |
Gene Information
Entrez Gene ID
Gene Name
carnitine palmitoyltransferase 1c
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0032281 | IDA:MGI | C | alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex |
| GO:0030054 | IEA:UniProtKB-KW | C | cell junction |
| GO:0005789 | IEA:Ensembl | C | endoplasmic reticulum membrane |
| GO:0005741 | IEA:UniProtKB-KW | C | mitochondrial outer membrane |
| GO:0005739 | IDA:MGI | C | mitochondrion |
| GO:0045202 | IEA:UniProtKB-KW | C | synapse |
| GO:0004095 | IEA:UniProtKB-EC | F | carnitine O-palmitoyltransferase activity |
| GO:0009437 | IEA:Ensembl | P | carnitine metabolic process |
| GO:0006635 | IEA:UniProtKB-UniPathway | P | fatty acid beta-oxidation |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR000542 | Acyltransferase ChoActase/COT/CPT |
UniProt Annotations
Entry Information
Gene Name
carnitine palmitoyltransferase 1c
Protein Entry
CPT1C_MOUSE
UniProt ID
Species
Mouse
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Palmitoyl-CoA + L-carnitine = CoA + L- palmitoylcarnitine. |
| Pathway | Lipid metabolism; fatty acid beta-oxidation. |
| Similarity | Belongs to the carnitine/choline acetyltransferase family. {ECO:0000305}. |
| Subcellular Location | Mitochondrion outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000305|PubMed:22632720}. |
| Subunit | Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including CPT1C. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing. {ECO:0000269|PubMed:22632720}. |
| Tissue Specificity | Predominantly expressed in brain (at protein level) and testis. {ECO:0000269|PubMed:12376098, ECO:0000269|PubMed:22632720}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002774 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 24211027 | RefSeq | NP_710146 | 798 | carnitine O-palmitoyltransferase 1, brain isoform |
Identical Sequences to LMP002774 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:24211027 | DBBJ | BAC29187.1 | 798 | unnamed protein product [Mus musculus] |
| GI:24211027 | GenBank | AAN39013.1 | 798 | carnitine palmitoyltransferase I [Mus musculus] |
| GI:24211027 | GenBank | EDL22774.1 | 798 | carnitine palmitoyltransferase 1c [Mus musculus] |
| GI:24211027 | RefSeq | NP_001239399.1 | 798 | carnitine O-palmitoyltransferase 1, brain isoform [Mus musculus] |
| GI:24211027 | RefSeq | XP_006541344.1 | 798 | PREDICTED: carnitine O-palmitoyltransferase 1, brain isoform isoform X5 [Mus musculus] |
| GI:24211027 | SwissProt | Q8BGD5.1 | 798 | RecName: Full=Carnitine O-palmitoyltransferase 1, brain isoform; Short=CPT1-B; AltName: Full=CPT IC; AltName: Full=Carnitine O-palmitoyltransferase I, brain isoform; Short=CPTI-B; AltName: Full=Carnitine palmitoyltransferase 1C [Mus musculus] |
Related Sequences to LMP002774 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:24211027 | GenBank | AAH66155.1 | 798 | Carnitine palmitoyltransferase 1c [Mus musculus] |
| GI:24211027 | RefSeq | XP_006541340.1 | 799 | PREDICTED: carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [Mus musculus] |
| GI:24211027 | RefSeq | XP_006541341.1 | 799 | PREDICTED: carnitine O-palmitoyltransferase 1, brain isoform isoform X2 [Mus musculus] |
| GI:24211027 | RefSeq | XP_006541342.1 | 799 | PREDICTED: carnitine O-palmitoyltransferase 1, brain isoform isoform X3 [Mus musculus] |
| GI:24211027 | RefSeq | XP_006541343.1 | 799 | PREDICTED: carnitine O-palmitoyltransferase 1, brain isoform isoform X4 [Mus musculus] |
| GI:24211027 | SwissProt | F1LN46.1 | 801 | RecName: Full=Carnitine O-palmitoyltransferase 1, brain isoform; Short=CPT1-B; AltName: Full=CPT IC; AltName: Full=Carnitine O-palmitoyltransferase I, brain isoform; Short=CPTI-B; AltName: Full=Carnitine palmitoyltransferase 1C [Rattus norvegicus] |