Gene/Proteome Database (LMPD)
LMPD ID
LMP002786
Gene ID
Species
Homo sapiens (Human)
Gene Name
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
Gene Symbol
Synonyms
ADH4
Alternate Names
alcohol dehydrogenase class 4 mu/sigma chain; retinol dehydrogenase; alcohol dehydrogenase-7; alcohol dehydrogenase VII; gastric alcohol dehydrogenase; class IV sigma-1 alcohol dehydrogenase; class IV sigmasigma alcohol dehydrogenase; alcohol dehydrogenase class IV mu/sigma chain
Chromosome
4
Map Location
4q23-q24
EC Number
1.1.1.1
Summary
This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Orthologs
Proteins
| alcohol dehydrogenase class 4 mu/sigma chain isoform 1 | |
|---|---|
| Refseq ID | NP_001159976 |
| Protein GI | 262073058 |
| UniProt ID | P40394 |
| mRNA ID | NM_001166504 |
| Length | 394 |
| RefSeq Status | REVIEWED |
| MKCLVSRHTVRETLDMVFQRMSVEAGVIKCKAAVLWEQKQPFSIEEIEVAPPKTKEVRIKILATGICRTDDHVIKGTMVSKFPVIVGHEATGIVESIGEGVTTVKPGDKVIPLFLPQCRECNACRNPDGNLCIRSDITGRGVLADGTTRFTCKGKPVHHFMNTSTFTEYTVVDESSVAKIDDAAPPEKVCLIGCGFSTGYGAAVKTGKVKPGSTCVVFGLGGVGLSVIMGCKSAGASRIIGIDLNKDKFEKAMAVGATECISPKDSTKPISEVLSEMTGNNVGYTFEVIGHLETMIDALASCHMNYGTSVVVGVPPSAKMLTYDPMLLFTGRTWKGCVFGGLKSRDDVPKLVTEFLAKKFDLDQLITHVLPFKKISEGFELLNSGQSIRTVLTF | |
| alcohol dehydrogenase class 4 mu/sigma chain isoform 2 | |
|---|---|
| Refseq ID | NP_000664 |
| Protein GI | 71743840 |
| UniProt ID | P40394 |
| mRNA ID | NM_000673 |
| Length | 386 |
| RefSeq Status | REVIEWED |
| MFAEIQIQDKDRMGTAGKVIKCKAAVLWEQKQPFSIEEIEVAPPKTKEVRIKILATGICRTDDHVIKGTMVSKFPVIVGHEATGIVESIGEGVTTVKPGDKVIPLFLPQCRECNACRNPDGNLCIRSDITGRGVLADGTTRFTCKGKPVHHFMNTSTFTEYTVVDESSVAKIDDAAPPEKVCLIGCGFSTGYGAAVKTGKVKPGSTCVVFGLGGVGLSVIMGCKSAGASRIIGIDLNKDKFEKAMAVGATECISPKDSTKPISEVLSEMTGNNVGYTFEVIGHLETMIDALASCHMNYGTSVVVGVPPSAKMLTYDPMLLFTGRTWKGCVFGGLKSRDDVPKLVTEFLAKKFDLDQLITHVLPFKKISEGFELLNSGQSIRTVLTF | |
Gene Information
Entrez Gene ID
Gene Name
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005829 | TAS:Reactome | C | cytosol |
| GO:0005576 | IDA:GOC | C | extracellular region |
| GO:0004022 | TAS:UniProtKB | F | alcohol dehydrogenase (NAD) activity |
| GO:0004024 | IDA:UniProtKB | F | alcohol dehydrogenase activity, zinc-dependent |
| GO:0004031 | IDA:UniProtKB | F | aldehyde oxidase activity |
| GO:0035276 | IDA:UniProtKB | F | ethanol binding |
| GO:0048019 | IDA:UniProtKB | F | receptor antagonist activity |
| GO:0019841 | IDA:UniProtKB | F | retinol binding |
| GO:0004745 | IDA:UniProtKB | F | retinol dehydrogenase activity |
| GO:0008270 | IEA:InterPro | F | zinc ion binding |
| GO:0006068 | IEA:Ensembl | P | ethanol catabolic process |
| GO:0006069 | IDA:UniProtKB | P | ethanol oxidation |
| GO:1900116 | IDA:GOC | P | extracellular negative regulation of signal transduction |
| GO:0010430 | IDA:UniProtKB | P | fatty acid omega-oxidation |
| GO:0055114 | IDA:UniProtKB | P | oxidation-reduction process |
| GO:0009617 | IDA:UniProtKB | P | response to bacterium |
| GO:0045471 | IDA:UniProtKB | P | response to ethanol |
| GO:0042573 | IEA:Ensembl | P | retinoic acid metabolic process |
| GO:0001523 | IDA:UniProtKB | P | retinoid metabolic process |
| GO:0042572 | IEA:Ensembl | P | retinol metabolic process |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
| GO:0006805 | TAS:Reactome | P | xenobiotic metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa05204 | Chemical carcinogenesis |
| hsa00982 | Drug metabolism - cytochrome P450 |
| hsa00010 | Glycolysis / Gluconeogenesis |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_34 | Ethanol oxidation |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR013154 | Alcohol dehydrogenase GroES-like |
| IPR028635 | Alcohol dehydrogenase family, zinc-type, class-IV subfamily |
| IPR002085 | Alcohol dehydrogenase superfamily, zinc-type |
| IPR013149 | Alcohol dehydrogenase, C-terminal |
| IPR002328 | Alcohol dehydrogenase, zinc-type, conserved site |
| IPR011032 | GroES (chaperonin 10)-like |
| IPR016040 | NAD(P)-binding domain |
UniProt Annotations
Entry Information
Gene Name
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
Protein Entry
ADH7_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P40394-1; Sequence=Displayed; Name=2; IsoId=P40394-2; Sequence=VSP_043093; Note=No experimental confirmation available.; |
| Catalytic Activity | An alcohol + NAD(+) = an aldehyde or ketone + NADH. |
| Caution | It is uncertain whether Met-1 or Met-13 is the initiator. |
| Cofactor | Name=Zn(2+); Xref=ChEBI |
| Function | Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism. |
| Miscellaneous | There are 7 different ADH's isozymes in human: three belongs to class-I |
| Sequence Caution | Sequence=AAA19002.1; Type=Erroneous initiation; Evidence= ; Sequence=AAC51351.1; Type=Erroneous initiation; Evidence= ; Sequence=BAG35707.1; Type=Erroneous initiation; Evidence= ; Sequence=CAA53960.1; Type=Erroneous initiation; Evidence= ; Sequence=CAA53961.1; Type=Erroneous initiation; Evidence= ; |
| Similarity | Belongs to the zinc-containing alcohol dehydrogenase family. Class-IV subfamily. |
| Subcellular Location | Cytoplasm. |
| Subunit | Homodimer. |
| Tissue Specificity | Preferentially expressed in stomach. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002786 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 262073058 | RefSeq | NP_001159976 | 394 | alcohol dehydrogenase class 4 mu/sigma chain isoform 1 |
| 71743840 | RefSeq | NP_000664 | 386 | alcohol dehydrogenase class 4 mu/sigma chain isoform 2 |
Identical Sequences to LMP002786 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:262073058 | DBBJ | BAG63168.1 | 394 | unnamed protein product [Homo sapiens] |
| GI:71743840 | GenBank | ACP57507.1 | 386 | Sequence 1636 from patent US 7482117 |
| GI:71743840 | GenBank | ADS31104.1 | 386 | Sequence 1636 from patent US 7781168 |
| GI:71743840 | GenBank | AIC48226.1 | 386 | ADH7, partial [synthetic construct] |
| GI:71743840 | RefSeq | XP_003829978.1 | 386 | PREDICTED: alcohol dehydrogenase class 4 mu/sigma chain isoform X2 [Pan paniscus] |
| GI:262073058 | RefSeq | XP_003829979.1 | 394 | PREDICTED: alcohol dehydrogenase class 4 mu/sigma chain isoform X1 [Pan paniscus] |
| GI:71743840 | RefSeq | XP_004040224.1 | 386 | PREDICTED: alcohol dehydrogenase class 4 mu/sigma chain [Gorilla gorilla gorilla] |
| GI:71743840 | SwissProt | P40394.2 | 386 | RecName: Full=Alcohol dehydrogenase class 4 mu/sigma chain; AltName: Full=Alcohol dehydrogenase class IV mu/sigma chain; AltName: Full=Gastric alcohol dehydrogenase; AltName: Full=Retinol dehydrogenase [Homo sapiens] |
Related Sequences to LMP002786 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:71743840 | GenBank | AAN88092.1 | 386 | Sequence 81 from patent US 6444425 |
| GI:71743840 | GenBank | AAV23830.1 | 386 | Sequence 81 from patent US 6759508 |
| GI:71743840 | GenBank | ACM85381.1 | 402 | Sequence 10879 from patent US 6812339 |
| GI:262073058 | GenBank | EHH26072.1 | 394 | hypothetical protein EGK_15956 [Macaca mulatta] |
| GI:262073058 | GenBank | EHH53858.1 | 394 | hypothetical protein EGM_14565 [Macaca fascicularis] |
| GI:71743840 | RefSeq | XP_526639.2 | 386 | PREDICTED: alcohol dehydrogenase class 4 mu/sigma chain isoform X2 [Pan troglodytes] |
| GI:71743840 | RefSeq | XP_002815038.1 | 386 | PREDICTED: alcohol dehydrogenase class 4 mu/sigma chain isoform X2 [Pongo abelii] |
| GI:71743840 | RefSeq | XP_003257551.1 | 386 | PREDICTED: alcohol dehydrogenase class 4 mu/sigma chain isoform 1 [Nomascus leucogenys] |
| GI:262073058 | RefSeq | XP_003310440.1 | 394 | PREDICTED: alcohol dehydrogenase class 4 mu/sigma chain isoform X1 [Pan troglodytes] |
| GI:262073058 | RefSeq | XP_005555580.1 | 394 | PREDICTED: alcohol dehydrogenase class 4 mu/sigma chain isoform X1 [Macaca fascicularis] |
| GI:262073058 | RefSeq | XP_009238487.1 | 390 | PREDICTED: alcohol dehydrogenase class 4 mu/sigma chain isoform X1 [Pongo abelii] |
| GI:262073058 | RefSeq | XP_010369934.1 | 394 | PREDICTED: alcohol dehydrogenase class 4 mu/sigma chain isoform X1 [Rhinopithecus roxellana] |