Gene/Proteome Database (LMPD)

LMPD ID
LMP002791
Gene ID
127
Species
Homo sapiens (Human)
Gene Name
alcohol dehydrogenase 4 (class II), pi polypeptide
Gene Symbol
ADH4
Synonyms
ADH-2; HEL-S-4
Alternate Names
alcohol dehydrogenase 4; aldehyde reductase; epididymis secretory protein Li 4; alcohol dehydrogenase class II pi chain
Chromosome
4
Map Location
4q22
EC Number
1.1.1.1
Summary
This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for ADH4

Proteins

alcohol dehydrogenase 4
Refseq ID NP_000661
Protein GI 71565152
UniProt ID P08319
mRNA ID NM_000670
Length 380
RefSeq Status REVIEWED
MGTKGKVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDATVIDSKFEGLAFPVIVGHEAAGIVESIGPGVTNVKPGDKVIPLYAPLCRKCKFCLSPLTNLCGKISNLKSPASDQQLMEDKTSRFTCKGKPVYHFFGTSTFSQYTVVSDINLAKIDDDANLERVCLLGCGFSTGYGAAINNAKVTPGSTCAVFGLGGVGLSAVMGCKAAGASRIIGIDINSEKFVKAKALGATDCLNPRDLHKPIQEVIIELTKGGVDFALDCAGGSETMKAALDCTTAGWGSCTFIGVAAGSKGLTIFPEELIIGRTINGTFFGGWKSVDSIPKLVTDYKNKKFNLDALVTHTLPFDKISEAFDLMNQGKSVRTILIF

Gene Information

Entrez Gene ID
127
Gene Name
alcohol dehydrogenase 4 (class II), pi polypeptide
Gene Symbol
ADH4
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 TAS:Reactome C cytosol
GO:0051287 IDA:UniProtKB F NAD binding
GO:0003960 ISS:UniProtKB F NADPH:quinone reductase activity
GO:0004022 IDA:UniProtKB F alcohol dehydrogenase (NAD) activity
GO:0004024 IDA:UniProtKB F alcohol dehydrogenase activity, zinc-dependent
GO:0004032 IEA:Ensembl F alditol:NADP+ 1-oxidoreductase activity
GO:0005503 IDA:UniProtKB F all-trans retinal binding
GO:0019115 IDA:UniProtKB F benzaldehyde dehydrogenase activity
GO:0035276 IEA:InterPro F ethanol binding
GO:0016620 IDA:UniProtKB F oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0019841 IDA:UniProtKB F retinol binding
GO:0004745 IDA:UniProtKB F retinol dehydrogenase activity
GO:0008270 IDA:UniProtKB F zinc ion binding
GO:0046164 ISS:UniProtKB P alcohol catabolic process
GO:0006066 IDA:UniProtKB P alcohol metabolic process
GO:0006081 IDA:UniProtKB P cellular aldehyde metabolic process
GO:0006069 IDA:UniProtKB P ethanol oxidation
GO:1901661 ISS:UniProtKB P quinone metabolic process
GO:0001523 IDA:UniProtKB P retinoid metabolic process
GO:0042572 IDA:UniProtKB P retinol metabolic process
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0006805 TAS:Reactome P xenobiotic metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa05204 Chemical carcinogenesis
hsa00010 Glycolysis / Gluconeogenesis

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6342 noradrenaline and adrenaline degradation

Domain Information

InterPro Annotations

Accession Description
IPR013154 Alcohol dehydrogenase GroES-like
IPR028632 Alcohol dehydrogenase family, zinc-type, class-II subfamily
IPR002085 Alcohol dehydrogenase superfamily, zinc-type
IPR013149 Alcohol dehydrogenase, C-terminal
IPR002328 Alcohol dehydrogenase, zinc-type, conserved site
IPR011032 GroES (chaperonin 10)-like
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
alcohol dehydrogenase 4 (class II), pi polypeptide
Protein Entry
ADH4_HUMAN
UniProt ID
P08319
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P08319-1; Sequence=Displayed; Name=2; IsoId=P08319-2; Sequence=VSP_036788;
Catalytic Activity An alcohol + NAD(+) = an aldehyde or ketone + NADH.
Cofactor Name=Zn(2+); Xref=ChEBI
Miscellaneous There are 7 different ADH's isozymes in human: three belongs to class-I
Similarity Belongs to the zinc-containing alcohol dehydrogenase family. Class-II subfamily.
Subcellular Location Cytoplasm.
Subunit Homodimer.
Web Resource Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/adh4/";

Identical and Related Proteins

Unique RefSeq proteins for LMP002791 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
71565152 RefSeq NP_000661 380 alcohol dehydrogenase 4

Identical Sequences to LMP002791 proteins

Reference Database Accession Length Protein Name
GI:71565152 DBBJ BAF83524.1 380 unnamed protein product [Homo sapiens]
GI:71565152 GenBank AHE01097.1 380 Sequence 56013 from patent US 8586006
GI:71565152 SwissProt P08319.5 380 RecName: Full=Alcohol dehydrogenase 4; AltName: Full=Alcohol dehydrogenase class II pi chain [Homo sapiens]

Related Sequences to LMP002791 proteins

Reference Database Accession Length Protein Name
GI:71565152 GenBank AAH22319.1 380 Alcohol dehydrogenase 4 (class II), pi polypeptide [Homo sapiens]
GI:71565152 GenBank EAX06088.1 380 alcohol dehydrogenase 4 (class II), pi polypeptide, isoform CRA_a [Homo sapiens]
GI:71565152 GenBank EAX06089.1 380 alcohol dehydrogenase 4 (class II), pi polypeptide, isoform CRA_a [Homo sapiens]
GI:71565152 GenBank ACM83494.1 399 Sequence 8992 from patent US 6812339
GI:71565152 GenBank ADQ32176.1 380 alcohol dehydrogenase 4 (class II), pi polypeptide, partial [synthetic construct]
GI:71565152 GenBank AIC53961.1 380 ADH4, partial [synthetic construct]