Gene/Proteome Database (LMPD)
LMPD ID
LMP002791
Gene ID
Species
Homo sapiens (Human)
Gene Name
alcohol dehydrogenase 4 (class II), pi polypeptide
Gene Symbol
Synonyms
ADH-2; HEL-S-4
Alternate Names
alcohol dehydrogenase 4; aldehyde reductase; epididymis secretory protein Li 4; alcohol dehydrogenase class II pi chain
Chromosome
4
Map Location
4q22
EC Number
1.1.1.1
Summary
This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| alcohol dehydrogenase 4 | |
|---|---|
| Refseq ID | NP_000661 |
| Protein GI | 71565152 |
| UniProt ID | P08319 |
| mRNA ID | NM_000670 |
| Length | 380 |
| RefSeq Status | REVIEWED |
| MGTKGKVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDATVIDSKFEGLAFPVIVGHEAAGIVESIGPGVTNVKPGDKVIPLYAPLCRKCKFCLSPLTNLCGKISNLKSPASDQQLMEDKTSRFTCKGKPVYHFFGTSTFSQYTVVSDINLAKIDDDANLERVCLLGCGFSTGYGAAINNAKVTPGSTCAVFGLGGVGLSAVMGCKAAGASRIIGIDINSEKFVKAKALGATDCLNPRDLHKPIQEVIIELTKGGVDFALDCAGGSETMKAALDCTTAGWGSCTFIGVAAGSKGLTIFPEELIIGRTINGTFFGGWKSVDSIPKLVTDYKNKKFNLDALVTHTLPFDKISEAFDLMNQGKSVRTILIF | |
Gene Information
Entrez Gene ID
Gene Name
alcohol dehydrogenase 4 (class II), pi polypeptide
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005829 | TAS:Reactome | C | cytosol |
| GO:0051287 | IDA:UniProtKB | F | NAD binding |
| GO:0003960 | ISS:UniProtKB | F | NADPH:quinone reductase activity |
| GO:0004022 | IDA:UniProtKB | F | alcohol dehydrogenase (NAD) activity |
| GO:0004024 | IDA:UniProtKB | F | alcohol dehydrogenase activity, zinc-dependent |
| GO:0004032 | IEA:Ensembl | F | alditol:NADP+ 1-oxidoreductase activity |
| GO:0005503 | IDA:UniProtKB | F | all-trans retinal binding |
| GO:0019115 | IDA:UniProtKB | F | benzaldehyde dehydrogenase activity |
| GO:0035276 | IEA:InterPro | F | ethanol binding |
| GO:0016620 | IDA:UniProtKB | F | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| GO:0019841 | IDA:UniProtKB | F | retinol binding |
| GO:0004745 | IDA:UniProtKB | F | retinol dehydrogenase activity |
| GO:0008270 | IDA:UniProtKB | F | zinc ion binding |
| GO:0046164 | ISS:UniProtKB | P | alcohol catabolic process |
| GO:0006066 | IDA:UniProtKB | P | alcohol metabolic process |
| GO:0006081 | IDA:UniProtKB | P | cellular aldehyde metabolic process |
| GO:0006069 | IDA:UniProtKB | P | ethanol oxidation |
| GO:1901661 | ISS:UniProtKB | P | quinone metabolic process |
| GO:0001523 | IDA:UniProtKB | P | retinoid metabolic process |
| GO:0042572 | IDA:UniProtKB | P | retinol metabolic process |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
| GO:0006805 | TAS:Reactome | P | xenobiotic metabolic process |
KEGG Pathway Links
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY-6342 | noradrenaline and adrenaline degradation |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR013154 | Alcohol dehydrogenase GroES-like |
| IPR028632 | Alcohol dehydrogenase family, zinc-type, class-II subfamily |
| IPR002085 | Alcohol dehydrogenase superfamily, zinc-type |
| IPR013149 | Alcohol dehydrogenase, C-terminal |
| IPR002328 | Alcohol dehydrogenase, zinc-type, conserved site |
| IPR011032 | GroES (chaperonin 10)-like |
| IPR016040 | NAD(P)-binding domain |
UniProt Annotations
Entry Information
Gene Name
alcohol dehydrogenase 4 (class II), pi polypeptide
Protein Entry
ADH4_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P08319-1; Sequence=Displayed; Name=2; IsoId=P08319-2; Sequence=VSP_036788; |
| Catalytic Activity | An alcohol + NAD(+) = an aldehyde or ketone + NADH. |
| Cofactor | Name=Zn(2+); Xref=ChEBI |
| Miscellaneous | There are 7 different ADH's isozymes in human: three belongs to class-I |
| Similarity | Belongs to the zinc-containing alcohol dehydrogenase family. Class-II subfamily. |
| Subcellular Location | Cytoplasm. |
| Subunit | Homodimer. |
| Web Resource | Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/adh4/"; |
Identical and Related Proteins
Unique RefSeq proteins for LMP002791 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 71565152 | RefSeq | NP_000661 | 380 | alcohol dehydrogenase 4 |
Identical Sequences to LMP002791 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:71565152 | DBBJ | BAF83524.1 | 380 | unnamed protein product [Homo sapiens] |
| GI:71565152 | GenBank | AHE01097.1 | 380 | Sequence 56013 from patent US 8586006 |
| GI:71565152 | SwissProt | P08319.5 | 380 | RecName: Full=Alcohol dehydrogenase 4; AltName: Full=Alcohol dehydrogenase class II pi chain [Homo sapiens] |
Related Sequences to LMP002791 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:71565152 | GenBank | AAH22319.1 | 380 | Alcohol dehydrogenase 4 (class II), pi polypeptide [Homo sapiens] |
| GI:71565152 | GenBank | EAX06088.1 | 380 | alcohol dehydrogenase 4 (class II), pi polypeptide, isoform CRA_a [Homo sapiens] |
| GI:71565152 | GenBank | EAX06089.1 | 380 | alcohol dehydrogenase 4 (class II), pi polypeptide, isoform CRA_a [Homo sapiens] |
| GI:71565152 | GenBank | ACM83494.1 | 399 | Sequence 8992 from patent US 6812339 |
| GI:71565152 | GenBank | ADQ32176.1 | 380 | alcohol dehydrogenase 4 (class II), pi polypeptide, partial [synthetic construct] |
| GI:71565152 | GenBank | AIC53961.1 | 380 | ADH4, partial [synthetic construct] |