Gene/Proteome Database (LMPD)

LMPD ID
LMP002813
Gene ID
225742
Species
Mus musculus (Mouse)
Gene Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
Gene Symbol
St8sia5
Synonyms
ST8SiaV; Siat8e
Alternate Names
alpha-2,8-sialyltransferase 8E; SIAT8-E; sialyltransferase 8E; sialytransferase St8Sia V; sialyltransferase St8Sia V; sialyltransferase 8 (alpha-2, 8-sialyltransferase) E
Chromosome
18
Map Location
18 E3|18
EC Number
2.4.99.-

Proteins

alpha-2,8-sialyltransferase 8E isoform long
Refseq ID NP_038694
Protein GI 257467533
UniProt ID P70126
mRNA ID NM_013666
Length 412
RefSeq Status VALIDATED
MRYADPSANRDLLGNRTLLFIFICAFALVTLLQQILYSKSYIKRGFQFGWQRGDQQANWTGLFNDSDSPTEQNITGSSSRYFEFYKEPLEFNSTRCLELRQEILEVKVLSMVKQSELFERWKSLQICKWAMDTAEASLFKSTLSRCCNAPSFLFTTQKNTPVETNLRYEVESSGLYHIDQEIFKMFPKEMPYYRSQFKKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGIYTTDVGEKTDVVTVNPSIIIDRFHKLEKWRRPFFSVLQRYENASVLLPAFYNVRNTLVSFRVKYMLDDFQSRQPVYFFHPQYLSSVSRYWLSLGVRARRISTGLILVTAALELCEEVHLFGFWAFPMNPSGFFITHHYYDNVKPKPGFHAMPSEIFTFLRMHSRGILRVHTGTCNCC
alpha-2,8-sialyltransferase 8E isoform middle
Refseq ID NP_694764
Protein GI 257467535
UniProt ID Q3TRR3
mRNA ID NM_153124
Length 376
RefSeq Status VALIDATED
MRYADPSANRDLLGNRTLLFIFICAFALVTLLQQILYSKSYIKRYFEFYKEPLEFNSTRCLELRQEILEVKVLSMVKQSELFERWKSLQICKWAMDTAEASLFKSTLSRCCNAPSFLFTTQKNTPVETNLRYEVESSGLYHIDQEIFKMFPKEMPYYRSQFKKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGIYTTDVGEKTDVVTVNPSIIIDRFHKLEKWRRPFFSVLQRYENASVLLPAFYNVRNTLVSFRVKYMLDDFQSRQPVYFFHPQYLSSVSRYWLSLGVRARRISTGLILVTAALELCEEVHLFGFWAFPMNPSGFFITHHYYDNVKPKPGFHAMPSEIFTFLRMHSRGILRVHTGTCNCC

Gene Information

Entrez Gene ID
225742
Gene Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
Gene Symbol
St8sia5
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030173 IEA:InterPro C integral component of Golgi membrane
GO:0003828 IDA:MGI F alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
GO:0006486 IEA:UniProtKB-UniPathway P protein glycosylation
GO:0097503 IDA:GOC P sialylation

KEGG Pathway Links

KEGG Pathway ID Description
mmu00604 Glycosphingolipid biosynthesis - ganglio series
mmu01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
5893781 Sialic acid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR001675 Glycosyl transferase, family 29
IPR012163 Sialyltransferase

UniProt Annotations

Entry Information

Gene Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
Protein Entry
Q3TRR3_MOUSE
UniProt ID
Q3TRR3
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=V-L; Synonyms=Long; IsoId=P70126-1; Sequence=Displayed; Name=V-M; Synonyms=Middle; IsoId=P70126-2; Sequence=VSP_001789; Name=V-S; Synonyms=Short; IsoId=P70126-3; Sequence=VSP_001790;
Function May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3 respectively.
Pathway Protein modification; protein glycosylation.
Similarity Belongs to the glycosyltransferase 29 family. {ECO:0000305}.
Subcellular Location Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Tissue Specificity Highly expressed in brain. Expressed at low levels in other tissues, including liver, testis, lung, placenta and spleen.
Web Resource Name=Functional Glycomics Gateway - GTase; Note=ST8Sia V; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_660";

Identical and Related Proteins

Unique RefSeq proteins for LMP002813 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
257467533 RefSeq NP_038694 412 alpha-2,8-sialyltransferase 8E isoform long
257467535 RefSeq NP_694764 376 alpha-2,8-sialyltransferase 8E isoform middle

Identical Sequences to LMP002813 proteins

Reference Database Accession Length Protein Name
GI:257467535 DBBJ BAE36964.1 376 unnamed protein product [Mus musculus]
GI:257467533 SwissProt P70126.2 412 RecName: Full=Alpha-2,8-sialyltransferase 8E; AltName: Full=Sialyltransferase 8E; Short=SIAT8-E; AltName: Full=Sialyltransferase St8Sia V; Short=ST8SiaV [Mus musculus]

Related Sequences to LMP002813 proteins

Reference Database Accession Length Protein Name
GI:257467533 EMBL CAA66642.1 412 alpha-2,8-sialyltransferase [Mus musculus]
GI:257467535 EMBL CAA66643.1 376 unnamed protein product [Mus musculus]
GI:257467535 EMBL CAG27884.1 376 alpha-2,8-sialyltransferase [Rattus norvegicus]
GI:257467535 GenBank AAH34855.1 376 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 [Mus musculus]
GI:257467535 RefSeq NP_998793.1 376 alpha-2,8-sialyltransferase 8E [Rattus norvegicus]
GI:257467533 RefSeq XP_006255030.1 412 PREDICTED: alpha-2,8-sialyltransferase 8E isoform X1 [Rattus norvegicus]
GI:257467533 RefSeq XP_006526492.1 413 PREDICTED: alpha-2,8-sialyltransferase 8E isoform X1 [Mus musculus]
GI:257467535 RefSeq XP_006526493.1 377 PREDICTED: alpha-2,8-sialyltransferase 8E isoform X2 [Mus musculus]
GI:257467533 RefSeq XP_006973908.1 413 PREDICTED: alpha-2,8-sialyltransferase 8E isoform X1 [Peromyscus maniculatus bairdii]
GI:257467533 RefSeq XP_006973909.1 412 PREDICTED: alpha-2,8-sialyltransferase 8E isoform X2 [Peromyscus maniculatus bairdii]
GI:257467533 RefSeq XP_007629480.1 412 PREDICTED: alpha-2,8-sialyltransferase 8E isoform X2 [Cricetulus griseus]
GI:257467535 SwissProt P70126.2 412 RecName: Full=Alpha-2,8-sialyltransferase 8E; AltName: Full=Sialyltransferase 8E; Short=SIAT8-E; AltName: Full=Sialyltransferase St8Sia V; Short=ST8SiaV [Mus musculus]