Gene/Proteome Database (LMPD)

LMPD ID
LMP002821
Gene ID
15493
Species
Mus musculus (Mouse)
Gene Name
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
Gene Symbol
Hsd3b2
Synonyms
-
Alternate Names
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2; 3-beta-HSD II; 3 beta-hydroxysteroid dehydrogenase 2; hydroxysteroid dehydrogenase-2, delta<5>-3-beta; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II
Chromosome
3
Map Location
3 F2.2|3 42.85 cM
EC Number
1.1.1.145

Proteins

3 beta-hydroxysteroid dehydrogenase/Delta 5--&gt;4-isomerase type 2
Refseq ID NP_694873
Protein GI 162461559
UniProt ID P26149
mRNA ID NM_153193
Length 373
RefSeq Status VALIDATED
MPGWSCLVTGAGGFLGQRIIQLLVQEEDLEEIRVLDKVFRPETRKEFFNLETSIKVTVLEGDILDTQYLRRACQGISVVIHTAAIIDVTGVIPRQTILDVNLKGTQNLLEACIQASVPAFIFSSSVDVAGPNSYKEIVLNGHEEECHESTWSDPYPYSKKMAEKAVLAANGSMLKNGGTLQTCALRPMCIYGERSPLISNIIIMALKHKGILRSFGKFNTANPVYVGNVAWAHILAARGLRDPKKSPNIQGEFYYISDDTPHQSFDDISYTLSKEWGFCLDSSWSLPVPLLYWLAFLLETVSFLLSPIYRYIPPFNRHLVTLSGSTFTFSYKKAQRDLGYEPLVSWEEAKQKTSEWIGTLVEQHRETLDTKSQ

Gene Information

Entrez Gene ID
15493
Gene Name
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
Gene Symbol
Hsd3b2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0003854 IEA:UniProtKB-EC F 3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0004769 IEA:UniProtKB-EC F steroid delta-isomerase activity
GO:0006694 IEA:UniProtKB-UniPathway P steroid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu04913 Ovarian steroidogenesis
mmu00140 Steroid hormone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
Protein Entry
3BHS2_MOUSE
UniProt ID
P26149
Species
Mouse

Comments

Comment Type Description
Catalytic Activity A 3-beta-hydroxy-Delta(5)-steroid + NAD(+) = a 3-oxo-Delta(5)-steroid + NADH.
Catalytic Activity A 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)- steroid.
Function 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.
Pathway Lipid metabolism; steroid biosynthesis.
Similarity Belongs to the 3-beta-HSD family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Tissue Specificity Liver and kidney.

Identical and Related Proteins

Unique RefSeq proteins for LMP002821 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
162461559 RefSeq NP_694873 373 3 beta-hydroxysteroid dehydrogenase/Delta 5--&gt;4-isomerase type 2

Identical Sequences to LMP002821 proteins

Reference Database Accession Length Protein Name
GI:162461559 RefSeq XP_006501101.1 373 PREDICTED: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 isoform X1 [Mus musculus]
GI:162461559 SwissProt P26149.4 373 RecName: Full=3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2; AltName: Full=3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II; Short=3-beta-HSD II; Includes: RecName: Full=3-beta-hydroxy-Delta(5)-steroid dehydrogenase; AltName: Full=3-beta-hydroxy-5-ene steroid dehydrogenase; AltName: Full=Progesterone reductase; Includes: RecName: Full=Steroid Delta-isomerase; AltName: Full=Delta-5-3-ketosteroid isomerase [Mus musculus]

Related Sequences to LMP002821 proteins

Reference Database Accession Length Protein Name
GI:162461559 GenBank AAH26757.1 373 Hsd3b2 protein [Mus musculus]
GI:162461559 GenBank AAH40397.1 373 Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 [Mus musculus]
GI:162461559 GenBank EDL38965.1 373 mCG119535, isoform CRA_a [Mus musculus]
GI:162461559 GenBank EDL38966.1 373 mCG119535, isoform CRA_a [Mus musculus]
GI:162461559 RefSeq XP_006501104.1 373 PREDICTED: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3 isoform X3 [Mus musculus]
GI:162461559 RefSeq XP_006501105.1 373 PREDICTED: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3 isoform X4 [Mus musculus]