Gene/Proteome Database (LMPD)

LMPD ID
LMP002822
Gene ID
13983
Species
Mus musculus (Mouse)
Gene Name
estrogen receptor 2 (beta)
Gene Symbol
Esr2
Synonyms
ER[b]; ERbeta; Estrb
Alternate Names
estrogen receptor beta; ER beta; ER-beta; oestrogen receptor beta; nuclear receptor subfamily 3 group A member 2
Chromosome
12
Map Location
12 D1-D3|12 33.52 cM

Proteins

estrogen receptor beta isoform 1
Refseq ID NP_997590
Protein GI 46877096
UniProt ID O08537
mRNA ID NM_207707
Length 567
RefSeq Status VALIDATED
MSICASSHKDFSQLRPTQDMEIKNSPSSLTSPASYNCSQSILPLEHGPIYIPSSYVESRHEYSAMTFYSPAVMNYSVPSSTGNLEGGPVRQTASPNVLWPTSGHLSPLATHCQSSLLYAEPQKSPWCEARSLEHTLPVNRETLKRKLGGSGCASPVTSPSAKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRIVRRQRSASEQVHCLNKAKRTSGHTPRVKELLLNSLSPEQLVLTLLEAEPPNVLVSRPSMPFTEASMMMSLTKLADKELVHMIGWAKKIPGFVELSLLDQVRLLESCWMEVLMVGLMWRSIDHPGKLIFAPDLVLDRSSEDPHWHVAQTKSAVPRDEGKCVEGILEIFDMLLATTARFRELKLQHKEYLCVKAMILLNSSMYPLATASQEAESSRKLTHLLNAVTDALVWVISKSGISSQQQSVRLANLLMLLSHVRHISNKGMEHLLSMKCKNVVPVYDLLLEMLNAHTLRGYKSSISGSECCSTEDSKSKEGSQNLQSQ
estrogen receptor beta isoform 2
Refseq ID NP_034287
Protein GI 46877094
UniProt ID O08537
mRNA ID NM_010157
Length 549
RefSeq Status VALIDATED
MSICASSHKDFSQLRPTQDMEIKNSPSSLTSPASYNCSQSILPLEHGPIYIPSSYVESRHEYSAMTFYSPAVMNYSVPSSTGNLEGGPVRQTASPNVLWPTSGHLSPLATHCQSSLLYAEPQKSPWCEARSLEHTLPVNRETLKRKLGGSGCASPVTSPSAKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRIVRRQRSASEQVHCLNKAKRTSGHTPRVKELLLNSLSPEQLVLTLLEAEPPNVLVSRPSMPFTEASMMMSLTKLADKELVHMIGWAKKIPGFVELSLLDQVRLLESCWMEVLMVGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTARFRELKLQHKEYLCVKAMILLNSSMYPLATASQEAESSRKLTHLLNAVTDALVWVISKSGISSQQQSVRLANLLMLLSHVRHISNKGMEHLLSMKCKNVVPVYDLLLEMLNAHTLRGYKSSISGSECCSTEDSKSKEGSQNLQSQ

Gene Information

Entrez Gene ID
13983
Gene Name
estrogen receptor 2 (beta)
Gene Symbol
Esr2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:MGI C cytoplasm
GO:0005739 IEA:Ensembl C mitochondrion
GO:0005634 IDA:MGI C nucleus
GO:0003677 IDA:MGI F DNA binding
GO:0001046 IEA:Ensembl F core promoter sequence-specific DNA binding
GO:0030284 IEA:InterPro F estrogen receptor activity
GO:0034056 IEA:Ensembl F estrogen response element binding
GO:0004879 IEA:Ensembl F ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005496 ISS:UniProtKB F steroid binding
GO:0008270 IEA:InterPro F zinc ion binding
GO:0007420 IMP:MGI P brain development
GO:0060743 IMP:MGI P epithelial cell maturation involved in prostate gland development
GO:0008628 IMP:MGI P hormone-mediated apoptotic signaling pathway
GO:0030520 IMP:MGI P intracellular estrogen receptor signaling pathway
GO:0060766 IMP:MGI P negative regulation of androgen receptor signaling pathway
GO:0008285 IGI:MGI P negative regulation of cell proliferation
GO:0050680 IMP:MGI P negative regulation of epithelial cell proliferation
GO:0000122 IEA:Ensembl P negative regulation of transcription from RNA polymerase II promoter
GO:0001764 IMP:MGI P neuron migration
GO:0001541 IMP:MGI P ovarian follicle development
GO:0051091 ISS:UniProtKB P positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060740 IMP:MGI P prostate gland epithelium morphogenesis
GO:0042127 IMP:MGI P regulation of cell proliferation
GO:0060065 IGI:MGI P uterus development
GO:0060068 IGI:MGI P vagina development

KEGG Pathway Links

KEGG Pathway ID Description
mmu04915 Estrogen signaling pathway
mmu04917 Prolactin signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR021064 Estrogen receptor beta, N-terminal
IPR028355 Estrogen receptor beta/gamma
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR024178 Oestrogen receptor/oestrogen-related receptor
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
estrogen receptor 2 (beta)
Protein Entry
ESR2_MOUSE
UniProt ID
O08537
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=5; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=Beta-1; IsoId=O08537-1; Sequence=Displayed; Name=2; Synonyms=Beta-2; IsoId=O08537-2; Sequence=VSP_003693; Name=3; Synonyms=Beta-5A; IsoId=O08537-4; Sequence=VSP_003696; Note=Corresponds to exons 5 and 6 deletion. {ECO:0000305|PubMed:9685228}; Name=4; IsoId=O08537-6; Sequence=VSP_042429, VSP_042430; Note=Corresponds to exon 5 deletion (PubMed:9685228). May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available. {ECO:0000305|PubMed:9685228}; Name=5; IsoId=O08537-7; Sequence=VSP_042431, VSP_042432; Note=Corresponds to exon 6 deletion (PubMed:9685228). May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available. {ECO:0000305|PubMed:9685228};
Domain Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Function Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 (ER-alpha), and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. May play a role in ovarian follicular growth and maturation.
Induction Isoforms 1 and 2 are down-regulated by 17-beta- estradiol. {ECO:0000269|PubMed:11878304}.
Interaction P01101:Fos; NbExp=2; IntAct=EBI-2526214, EBI-4288185;
Ptm Phosphorylation at Ser-87 and Ser-105 recruits NCOA1. {ECO:0000269|PubMed:10230404, ECO:0000269|PubMed:10995228}.
Sequence Caution Sequence=AAC17919.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAI41076.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAI45330.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAL15175.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC35719.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC35770.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Similarity Belongs to the nuclear hormone receptor family. NR3 subfamily. {ECO:0000305}.
Similarity Contains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular Location Nucleus.
Subunit Binds DNA as a homodimer. Can form a heterodimer with ESR1. Interacts with NCOA1, NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with PELP1, UBE1C and AKAP13. Interacts with DNTTIP2 (By similarity). Interacts with CCDC62 in the presence of estradiol/E2; this interaction seems to enhance the transcription of target genes. Interacts with DYX1C1. Interacts with PRMT2 (By similarity). {ECO:0000250}.
Tissue Specificity Expressed in prostate, ovary, Leydig cells and in epithelium of the efferent ductules and of the initial segment of the epididymis. {ECO:0000269|PubMed:9607809}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002822 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
46877096 RefSeq NP_997590 567 estrogen receptor beta isoform 1
46877094 RefSeq NP_034287 549 estrogen receptor beta isoform 2

Identical Sequences to LMP002822 proteins

Reference Database Accession Length Protein Name
GI:46877096 DBBJ BAC35719.1 567 unnamed protein product [Mus musculus]
GI:46877096 DBBJ BAC35770.1 567 unnamed protein product [Mus musculus]
GI:46877094 GenBank AAI41076.1 549 Estrogen receptor 2 (beta) [Mus musculus]
GI:46877094 GenBank AAI45330.1 549 Estrogen receptor 2 (beta) [Mus musculus]

Related Sequences to LMP002822 proteins

Reference Database Accession Length Protein Name
GI:46877094 DBBJ BAC35719.1 567 unnamed protein product [Mus musculus]
GI:46877094 DBBJ BAC35770.1 567 unnamed protein product [Mus musculus]
GI:46877094 DBBJ BAD91173.1 549 estrogen receptor beta1 [Rattus norvegicus]
GI:46877096 DBBJ BAD91174.1 567 estrogen receptor beta2 [Rattus norvegicus]
GI:46877096 GenBank EDM03650.1 567 estrogen receptor 2 beta, isoform CRA_a [Rattus norvegicus]
GI:46877094 GenBank EDM03652.1 549 estrogen receptor 2 beta, isoform CRA_c [Rattus norvegicus]
GI:46877096 GenBank AAI41076.1 549 Estrogen receptor 2 (beta) [Mus musculus]
GI:46877096 GenBank AAI45330.1 549 Estrogen receptor 2 (beta) [Mus musculus]
GI:46877096 RefSeq NP_034287.3 549 estrogen receptor beta isoform 2 [Mus musculus]
GI:46877094 RefSeq NP_997590.1 567 estrogen receptor beta isoform 1 [Mus musculus]
GI:46877096 RefSeq XP_006240283.1 567 PREDICTED: estrogen receptor beta isoform X1 [Rattus norvegicus]
GI:46877094 SwissProt O08537.3 530 RecName: Full=Estrogen receptor beta; Short=ER-beta; AltName: Full=Nuclear receptor subfamily 3 group A member 2 [Mus musculus]