Gene/Proteome Database (LMPD)

LMPD ID
LMP002823
Gene ID
116362
Species
Homo sapiens (Human)
Gene Name
retinol binding protein 7, cellular
Gene Symbol
RBP7
Synonyms
CRBP4; CRBPIV
Alternate Names
retinoid-binding protein 7; CRABP4; CRABP-IV; retinoid binding protein 7; cellular retinoic acid-binding protein 4; cellular retinoic acid-binding protein IV; putative cellular retinol-binding protein CRBP IV
Chromosome
1
Map Location
1p36.22
Summary
Due to its chemical instability and low solubility in aqueous solution, vitamin A requires cellular retinol-binding proteins (CRBPs), such as RBP7, for stability, internalization, intercellular transfer, homeostasis, and metabolism.[supplied by OMIM, May 2004]
Orthologs
View orthologs and multiple alignments for RBP7

Proteins

retinoid-binding protein 7
Refseq ID NP_443192
Protein GI 16418455
UniProt ID Q96R05
mRNA ID NM_052960
Length 134
RefSeq Status PROVISIONAL
MPADLSGTWTLLSSDNFEGYMLALGIDFATRKIAKLLKPQKVIEQNGDSFTIHTNSSLRNYFVKFKVGEEFDEDNRGLDNRKCKSLVIWDNDRLTCIQKGEKKNRGWTHWIEGDKLHLEMFCEGQVCKQTFQRA

Gene Information

Entrez Gene ID
116362
Gene Name
retinol binding protein 7, cellular
Gene Symbol
RBP7
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0016918 IEA:UniProtKB-KW F retinal binding
GO:0019841 IEA:UniProtKB-KW F retinol binding
GO:0005215 IEA:InterPro F transporter activity

Domain Information

InterPro Annotations

Accession Description
IPR012674 Calycin
IPR011038 Calycin-like
IPR000463 Cytosolic fatty-acid binding
IPR000566 Lipocalin/cytosolic fatty-acid binding domain

UniProt Annotations

Entry Information

Gene Name
retinol binding protein 7, cellular
Protein Entry
RET7_HUMAN
UniProt ID
Q96R05
Species
Human

Comments

Comment Type Description
Domain Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
Function Intracellular transport of retinol.
Similarity Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Subcellular Location Cytoplasm .
Tissue Specificity Expressed primarily in kidney, heart and transverse colon. Detected in adult lymph node, appendix, ascending colon, and in fetal heart and spleen.

Identical and Related Proteins

Unique RefSeq proteins for LMP002823 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16418455 RefSeq NP_443192 134 retinoid-binding protein 7

Identical Sequences to LMP002823 proteins

Reference Database Accession Length Protein Name
GI:16418455 DBBJ BAG34964.1 134 unnamed protein product [Homo sapiens]
GI:16418455 GenBank EAW71638.1 134 retinol binding protein 7, cellular, isoform CRA_b [Homo sapiens]
GI:16418455 GenBank ADQ33098.1 134 retinol binding protein 7, cellular, partial [synthetic construct]
GI:16418455 GenBank AGA37082.1 134 Sequence 164 from patent US 8314221
GI:16418455 GenBank AIC52893.1 134 RBP7, partial [synthetic construct]
GI:16418455 RefSeq XP_003949337.1 134 PREDICTED: retinoid-binding protein 7 isoform X1 [Pan troglodytes]

Related Sequences to LMP002823 proteins

Reference Database Accession Length Protein Name
GI:16418455 GenBank ADS15492.1 134 Sequence 12 from patent US 7759069
GI:16418455 GenBank JAB12703.1 134 retinoid-binding protein 7 [Callithrix jacchus]
GI:16418455 PDB 1LPJ 133 Chain A, Human Crbp Iv
GI:16418455 RefSeq XP_002811563.1 134 PREDICTED: retinoid-binding protein 7 [Pongo abelii]
GI:16418455 RefSeq XP_003822157.1 134 PREDICTED: retinoid-binding protein 7 [Pan paniscus]
GI:16418455 RefSeq XP_010350929.1 134 PREDICTED: retinoid-binding protein 7 [Rhinopithecus roxellana]