Gene/Proteome Database (LMPD)

LMPD ID
LMP002830
Gene ID
13360
Species
Mus musculus (Mouse)
Gene Name
7-dehydrocholesterol reductase
Gene Symbol
Dhcr7
Synonyms
AA409147
Alternate Names
7-dehydrocholesterol reductase; 7-DHC reductase; sterol Delta(7)-reductase
Chromosome
7
Map Location
7|7 F5
EC Number
1.3.1.21

Proteins

7-dehydrocholesterol reductase
Refseq ID NP_031882
Protein GI 6681179
UniProt ID O88455
mRNA ID NM_007856
Length 471
RefSeq Status VALIDATED
MASKSQHNAPKVKSPNGKAGSQGQWGRAWEVDWFSLASIIFLLLFAPFIVYYFIMACDQYSCSLTAPALDIATGHASLADIWAKTPPVTAKAAQLYALWVSFQVLLYSWLPDFCHRFLPGYVGGVQEGAITPAGVVNKYEVNGLQAWLITHILWFVNAYLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMIKGYLFPTSAEDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQQELYGHVTNSMILVNVLQAIYVLDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPNALGILLLGLVGYYIFRMTNHQKDLFRRTDGRCLIWGKKPKAIECSYTSADGLKHHSKLLVSGFWGVARHFNYTGDLMGSLAYCLACGGGHLLPYFYIIYMTILLTHRCLRDEHRCANKYGRDWERYTAAVPYRLLPGIF

Gene Information

Entrez Gene ID
13360
Gene Name
7-dehydrocholesterol reductase
Gene Symbol
Dhcr7
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005640 IEA:Ensembl C nuclear outer membrane
GO:0047598 IDA:MGI F 7-dehydrocholesterol reductase activity
GO:0001568 IMP:MGI P blood vessel development
GO:0030154 IMP:MGI P cell differentiation
GO:0006695 IEA:UniProtKB-UniPathway P cholesterol biosynthetic process
GO:0030324 IMP:MGI P lung development
GO:0035264 IMP:MGI P multicellular organism growth
GO:0009791 IMP:MGI P post-embryonic development
GO:0042127 IMP:MGI P regulation of cell proliferation
GO:0045540 IEA:Ensembl P regulation of cholesterol biosynthetic process
GO:0016126 IMP:MGI P sterol biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00100 Steroid biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5894006 Activation of gene expression by SREBF (SREBP)

Domain Information

InterPro Annotations

Accession Description
IPR001171 Ergosterol biosynthesis ERG4/ERG24
IPR018083 Sterol reductase, conserved site

UniProt Annotations

Entry Information

Gene Name
7-dehydrocholesterol reductase
Protein Entry
DHCR7_MOUSE
UniProt ID
O88455
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Cholesterol + NADP(+) = cholesta-5,7-dien-3- beta-ol + NADPH.
Function Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC).
Pathway Steroid biosynthesis; cholesterol biosynthesis.
Similarity Belongs to the ERG4/ERG24 family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP002830 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6681179 RefSeq NP_031882 471 7-dehydrocholesterol reductase

Identical Sequences to LMP002830 proteins

Reference Database Accession Length Protein Name
GI:6681179 GenBank EDL18238.1 471 7-dehydrocholesterol reductase, isoform CRA_a [Mus musculus]
GI:6681179 RefSeq XP_006508541.1 471 PREDICTED: 7-dehydrocholesterol reductase isoform X3 [Mus musculus]
GI:6681179 RefSeq XP_006508542.1 471 PREDICTED: 7-dehydrocholesterol reductase isoform X4 [Mus musculus]
GI:6681179 RefSeq XP_006508543.1 471 PREDICTED: 7-dehydrocholesterol reductase isoform X5 [Mus musculus]
GI:6681179 RefSeq XP_006508544.1 471 PREDICTED: 7-dehydrocholesterol reductase isoform X6 [Mus musculus]
GI:6681179 SwissProt O88455.1 471 RecName: Full=7-dehydrocholesterol reductase; Short=7-DHC reductase; AltName: Full=Sterol Delta(7)-reductase [Mus musculus]

Related Sequences to LMP002830 proteins

Reference Database Accession Length Protein Name
GI:6681179 DBBJ BAE27451.1 471 unnamed protein product [Mus musculus]
GI:6681179 EMBL CAJ18485.1 471 Dhcr7 [Mus musculus]
GI:6681179 GenBank AAD31383.1 471 7-dehydrocholesterol reductase [Rattus norvegicus]
GI:6681179 GenBank EDL18241.1 468 7-dehydrocholesterol reductase, isoform CRA_d [Mus musculus]
GI:6681179 RefSeq XP_006508539.1 530 PREDICTED: 7-dehydrocholesterol reductase isoform X1 [Mus musculus]
GI:6681179 RefSeq XP_006508540.1 520 PREDICTED: 7-dehydrocholesterol reductase isoform X2 [Mus musculus]