Gene/Proteome Database (LMPD)

LMPD ID
LMP002831
Gene ID
70086
Species
Mus musculus (Mouse)
Gene Name
cysteinyl leukotriene receptor 2
Gene Symbol
Cysltr2
Synonyms
2300001H05Rik; CYSLT2R; Cltr2; Cyslt2
Alternate Names
cysteinyl leukotriene receptor 2
Chromosome
14
Map Location
14 D3|14

Proteins

cysteinyl leukotriene receptor 2
Refseq ID NP_598481
Protein GI 242397434
UniProt ID Q920A1
mRNA ID NM_133720
Length 309
RefSeq Status VALIDATED
MEVTGTPSSYSNRNCTIENFKKEFYPIIYLIIFFWGALGNGFSIYVFLQTCKKSTSVNVFMLNLATSDFLFISTLPFRADYYFRGSNWIFGDLACRVMSYSLYVNMYTSIYFLTVLSVVRFLATVHPFRMFHVTSVRSAWILCGIIWVFIMASSALLLVNGQEEKDNIISCLELSPQKFKSLLIMNHIAVAVGFLLPFLTLTVCYLLIIRILLKAEIPESGPRAAHRKALTTIVIAMITFLLCFLPYHALRTLHLVTWDKDSCGDVLHKATVITLTMAAANSCFNPFLYYFAGENFKARLRAIFSKVHL
cysteinyl leukotriene receptor 2
Refseq ID NP_001155884
Protein GI 242397436
UniProt ID Q920A1
mRNA ID NM_001162412
Length 309
RefSeq Status VALIDATED
Protein sequence is identical to GI:242397434 (mRNA isoform)

Gene Information

Entrez Gene ID
70086
Gene Name
cysteinyl leukotriene receptor 2
Gene Symbol
Cysltr2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016020 IDA:MGI C membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0001631 IDA:MGI F cysteinyl leukotriene receptor activity
GO:0070374 IEA:Ensembl P positive regulation of ERK1 and ERK2 cascade
GO:0045766 IEA:Ensembl P positive regulation of angiogenesis
GO:0010942 IEA:Ensembl P positive regulation of cell death

KEGG Pathway Links

KEGG Pathway ID Description
mmu04020 Calcium signaling pathway
mmu04080 Neuroactive ligand-receptor interaction

REACTOME Pathway Links

REACTOME Pathway ID Description
5893714 Leukotriene receptors

Domain Information

InterPro Annotations

Accession Description
IPR004071 Cysteinyl leukotriene receptor
IPR013311 Cysteinyl leukotriene receptor 2
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM

UniProt Annotations

Entry Information

Gene Name
cysteinyl leukotriene receptor 2
Protein Entry
CLTR2_MOUSE
UniProt ID
Q920A1
Species
Mouse

Comments

Comment Type Description
Function Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol- calcium second messenger system. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.
Similarity Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Widely expressed at low levels, with highest expression in the spleen, thymus and adrenal gland, and lower in the kidney, brain and peripheral blood leukocytes.

Identical and Related Proteins

Unique RefSeq proteins for LMP002831 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
242397434 RefSeq NP_598481 309 cysteinyl leukotriene receptor 2

Identical Sequences to LMP002831 proteins

Reference Database Accession Length Protein Name
GI:242397434 GenBank AAI32415.1 309 Cysteinyl leukotriene receptor 2 [Mus musculus]
GI:242397434 GenBank AAI32419.1 309 Cysteinyl leukotriene receptor 2 [Mus musculus]
GI:242397434 GenBank EDL35864.1 309 cysteinyl leukotriene receptor 2, isoform CRA_a [Mus musculus]
GI:242397434 GenBank EDL35865.1 309 cysteinyl leukotriene receptor 2, isoform CRA_a [Mus musculus]
GI:242397434 RefSeq NP_001155884.1 309 cysteinyl leukotriene receptor 2 [Mus musculus]
GI:242397434 SwissProt Q920A1.2 309 RecName: Full=Cysteinyl leukotriene receptor 2; Short=CysLTR2 [Mus musculus]

Related Sequences to LMP002831 proteins

Reference Database Accession Length Protein Name
GI:242397434 DBBJ BAB60816.1 309 CysLT2 [Rattus norvegicus]
GI:242397434 DBBJ BAB86881.1 309 cysteinyl leukotriene 2 receptor [Mus musculus]
GI:242397434 GenBank AAK97354.1 309 cysteinyl leukotriene receptor type 2 [Mus musculus]
GI:242397434 RefSeq NP_596904.1 309 cysteinyl leukotriene receptor 2 [Rattus norvegicus]
GI:242397434 RefSeq XP_008769064.1 309 PREDICTED: cysteinyl leukotriene receptor 2 isoform X2 [Rattus norvegicus]
GI:242397434 SwissProt Q924T9.1 309 RecName: Full=Cysteinyl leukotriene receptor 2; Short=CysLTR2; AltName: Full=RSBPT32 [Rattus norvegicus]