Gene/Proteome Database (LMPD)
LMPD ID
LMP002835
Gene ID
Species
Homo sapiens (Human)
Gene Name
geranylgeranyl diphosphate synthase 1
Gene Symbol
Synonyms
GGPPS; GGPPS1
Alternate Names
geranylgeranyl pyrophosphate synthase; GGPPSase; GGPP synthase; geranyltranstransferase; farnesyltranstransferase; dimethylallyltranstransferase; farnesyl diphosphate synthase; (2E,6E)-farnesyl diphosphate synthase
Chromosome
1
Map Location
1q43
EC Number
2.5.1.-
Summary
This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]
Orthologs
Proteins
| geranylgeranyl pyrophosphate synthase | |
|---|---|
| Refseq ID | NP_001032354 |
| Protein GI | 83700220 |
| UniProt ID | O95749 |
| mRNA ID | NM_001037277 |
| Length | 300 |
| RefSeq Status | REVIEWED |
| MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE | |
Gene Information
Entrez Gene ID
Gene Name
geranylgeranyl diphosphate synthase 1
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005829 | TAS:Reactome | C | cytosol |
| GO:0004161 | IEA:UniProtKB-EC | F | dimethylallyltranstransferase activity |
| GO:0004311 | IDA:UniProtKB | F | farnesyltranstransferase activity |
| GO:0004337 | IEA:UniProtKB-EC | F | geranyltranstransferase activity |
| GO:0046872 | IEA:UniProtKB-KW | F | metal ion binding |
| GO:0006695 | TAS:Reactome | P | cholesterol biosynthetic process |
| GO:0045337 | IEA:UniProtKB-UniPathway | P | farnesyl diphosphate biosynthetic process |
| GO:0033384 | IEA:UniProtKB-UniPathway | P | geranyl diphosphate biosynthetic process |
| GO:0033386 | IEA:UniProtKB-UniPathway | P | geranylgeranyl diphosphate biosynthetic process |
| GO:0006720 | IDA:UniProtKB | P | isoprenoid metabolic process |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa00900 | Terpenoid backbone biosynthesis |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_147904 | Activation of gene expression by SREBF (SREBP) |
| REACT_9405 | Cholesterol biosynthesis |
| REACT_147797 | Regulation of cholesterol biosynthesis by SREBP (SREBF) |
Domain Information
UniProt Annotations
Entry Information
Gene Name
geranylgeranyl diphosphate synthase 1
Protein Entry
GGPPS_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O95749-1; Sequence=Displayed; Name=2; IsoId=O95749-2; Sequence=VSP_056578; Note=No experimental confirmation available.; |
| Biophysicochemical Properties | Kinetic parameters: KM=3 uM for isopentenyl diphosphate ; KM=4.2 uM for farnesyl diphosphate ; |
| Catalytic Activity | (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate. |
| Catalytic Activity | Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. |
| Catalytic Activity | Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate. |
| Cofactor | Name=Mg(2+); Xref=ChEBI |
| Enzyme Regulation | Subject to product inhibition by geranylgeranyl diphosphate. |
| Function | Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins. |
| Pathway | Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1. |
| Pathway | Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1. |
| Pathway | Isoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1. |
| Similarity | Belongs to the FPP/GGPP synthase family. |
| Subcellular Location | Cytoplasm. |
| Subunit | Homohexamer; trimer of homodimers. |
| Tissue Specificity | Abundantly expressed in testis. Found in other tissues to a lower extent. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002835 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 83700220 | RefSeq | NP_001032354 | 300 | geranylgeranyl pyrophosphate synthase |
Identical Sequences to LMP002835 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:83700220 | GenBank | JAA33609.1 | 300 | geranylgeranyl diphosphate synthase 1 [Pan troglodytes] |
| GI:83700220 | GenBank | JAA33610.1 | 300 | geranylgeranyl diphosphate synthase 1 [Pan troglodytes] |
| GI:83700220 | GenBank | AIC50359.1 | 300 | GGPS1, partial [synthetic construct] |
| GI:83700220 | RefSeq | XP_008976442.1 | 300 | PREDICTED: geranylgeranyl pyrophosphate synthase isoform X1 [Pan paniscus] |
| GI:83700220 | RefSeq | XP_009439972.1 | 300 | PREDICTED: geranylgeranyl pyrophosphate synthase isoform X1 [Pan troglodytes] |
| GI:83700220 | RefSeq | XP_009439973.1 | 300 | PREDICTED: geranylgeranyl pyrophosphate synthase isoform X1 [Pan troglodytes] |
Related Sequences to LMP002835 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:83700220 | PDB | 2Q80 | 301 | Chain A, Crystal Structure Of Human Geranylgeranyl Pyrophosphate Synthase Bound To Ggpp |
| GI:83700220 | PDB | 2Q80 | 301 | Chain B, Crystal Structure Of Human Geranylgeranyl Pyrophosphate Synthase Bound To Ggpp |
| GI:83700220 | PDB | 2Q80 | 301 | Chain C, Crystal Structure Of Human Geranylgeranyl Pyrophosphate Synthase Bound To Ggpp |
| GI:83700220 | PDB | 2Q80 | 301 | Chain D, Crystal Structure Of Human Geranylgeranyl Pyrophosphate Synthase Bound To Ggpp |
| GI:83700220 | PDB | 2Q80 | 301 | Chain E, Crystal Structure Of Human Geranylgeranyl Pyrophosphate Synthase Bound To Ggpp |
| GI:83700220 | PDB | 2Q80 | 301 | Chain F, Crystal Structure Of Human Geranylgeranyl Pyrophosphate Synthase Bound To Ggpp |