Gene/Proteome Database (LMPD)
Proteins
| ceramide kinase | |
|---|---|
| Refseq ID | NP_663450 |
| Protein GI | 62899061 |
| UniProt ID | Q8K4Q7 |
| mRNA ID | NM_145475 |
| Length | 531 |
| RefSeq Status | VALIDATED |
| MGAMGAAEPLHSVLWVKRRRCAVSLEPARALLRWWRSPEPGPSAPGADARSVLVSEIIAVEEKDDCEKHASSGRWHKMENPFAFTVHRVKRVRHHRWKWARVTFWSADEQLCHLWLQTLRGLLESLTSRPKHLLVFINPFGGKGQGKRIYEKTVAPLFTLASITTEIIITEHANQAKETLYEINTDSYDGIVCVGGDGMFSEVLHGVIGRTQQSAGIDPNHPRAVLVPSTLRIGIIPAGSTDCVCYSTVGTNDAETSALHIIIGDSLAIDVSSVHYHNTLLRYSVSLLGYGFYGDLIKDSEKKRWMGLVRYDFSGLKTFLSHQYYEGTLSFLPAQHTVGSPRDNKPCRAGCFVCRQSKQQLEEEEKKALYGLENAEEMEEWQVTCGKFLAINATNMSCACPRSPGGLSPFAHLGDGSSDLILIRKCSRFNFLRFLIRHTNQEDQFDFTFVEVYRVKKFHFTSKHVEDEDNDSKEQEKQKFGKICKDRPSCTCSASRSSWNCDGEVMHSPAIEVRVHCQLVRLFARGIEEES | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0016021 | ISS:UniProtKB | C | integral component of membrane |
| GO:0016020 | ISA:MGI | C | membrane |
| GO:0005739 | IDA:MGI | C | mitochondrion |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0001729 | ISS:UniProtKB | F | ceramide kinase activity |
| GO:0004143 | IEA:InterPro | F | diacylglycerol kinase activity |
| GO:0000287 | ISS:UniProtKB | F | magnesium ion binding |
| GO:0003951 | IEA:InterPro | F | NAD+ kinase activity |
| GO:0006672 | ISS:UniProtKB | P | ceramide metabolic process |
| GO:0046834 | ISO:GOC | P | lipid phosphorylation |
| GO:0007205 | IEA:InterPro | P | protein kinase C-activating G-protein coupled receptor signaling pathway |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| mmu00600 | Sphingolipid metabolism |
REACTOME Pathway Links
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | ATP + ceramide = ADP + ceramide 1-phosphate. |
| Cofactor | Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; |
| Cofactor | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; |
| Developmental Stage | Highly expressed at 7 dpc and decreases rapidly thereafter. |
| Function | Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines (By similarity). {ECO:0000250}. |
| Similarity | Contains 1 DAGKc domain. {ECO:0000255|PROSITE- ProRule:PRU00783}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. |
| Tissue Specificity | High level expression in heart, brain and testis; low expression in spleen, liver and lung; not detected in skeletal muscle. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002842 (as displayed in Record Overview)
Identical Sequences to LMP002842 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:62899061 | DBBJ | BAC31157.1 | 531 | unnamed protein product [Mus musculus] |
| GI:62899061 | DBBJ | BAE41212.1 | 531 | unnamed protein product [Mus musculus] |
| GI:62899061 | GenBank | AAH94253.1 | 531 | Ceramide kinase [Mus musculus] |
| GI:62899061 | SwissProt | Q8K4Q7.2 | 531 | RecName: Full=Ceramide kinase; Short=mCERK; AltName: Full=Acylsphingosine kinase [Mus musculus] |
Related Sequences to LMP002842 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:62899061 | DBBJ | BAC01155.1 | 531 | ceramide kinases [Mus musculus] |
| GI:62899061 | DBBJ | BAC34908.1 | 531 | unnamed protein product [Mus musculus] |
| GI:62899061 | GenBank | ERE86459.1 | 528 | ceramide kinase-like protein [Cricetulus griseus] |
| GI:62899061 | RefSeq | NP_001128333.1 | 531 | ceramide kinase [Rattus norvegicus] |
| GI:62899061 | RefSeq | XP_005354444.1 | 531 | PREDICTED: ceramide kinase [Microtus ochrogaster] |
| GI:62899061 | RefSeq | XP_006986139.1 | 531 | PREDICTED: ceramide kinase [Peromyscus maniculatus bairdii] |