Gene/Proteome Database (LMPD)
LMPD ID
LMP002852
Gene ID
Species
Homo sapiens (Human)
Gene Name
fructosamine 3 kinase
Gene Symbol
Synonyms
-
Alternate Names
fructosamine-3-kinase
Chromosome
17
Map Location
17q25.3
EC Number
2.7.1.-
Summary
A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way, fructosamines, are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of fructosamines which may result in deglycation. [provided by RefSeq, Feb 2012]
Orthologs
Proteins
| fructosamine-3-kinase | |
|---|---|
| Refseq ID | NP_071441 |
| Protein GI | 11545906 |
| UniProt ID | Q9H479 |
| mRNA ID | NM_022158 |
| Length | 309 |
| RefSeq Status | VALIDATED |
| MEQLLRAELRTATLRAFGGPGAGCISEGRAYDTDAGPVFVKVNRRTQARQMFEGEVASLEALRSTGLVRVPRPMKVIDLPGGGAAFVMEHLKMKSLSSQASKLGEQMADLHLYNQKLREKLKEEENTVGRRGEGAEPQYVDKFGFHTVTCCGFIPQVNEWQDDWPTFFARHRLQAQLDLIEKDYADREARELWSRLQVKIPDLFCGLEIVPALLHGDLWSGNVAEDDVGPIIYDPASFYGHSEFELAIALMFGGFPRSFFTAYHRKIPKAPGFDQRLLLYQLFNYLNHWNHFGREYRSPSLGTMRRLLK | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0030387 | NAS:UniProtKB | F | fructosamine-3-kinase activity |
| GO:0030855 | IEP:UniProt | P | epithelial cell differentiation |
| GO:0030393 | NAS:UniProtKB | P | fructoselysine metabolic process |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Function | May initiate a process leading to the deglycation of fructoselysine and of glycated proteins. May play a role in the phosphorylation of 1-deoxy-1-morpholinofructose (DMF), fructoselysine, fructoseglycine, fructose and glycated lysozyme. |
| Similarity | Belongs to the fructosamine kinase family. |
| Subunit | Monomer. |
| Tissue Specificity | Expressed in erythrocytes. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002852 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 11545906 | RefSeq | NP_071441 | 309 | fructosamine-3-kinase |
Identical Sequences to LMP002852 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:11545906 | GenBank | ADA41128.1 | 309 | Sequence 2 from patent US 7622117 |
| GI:11545906 | GenBank | ADF19834.1 | 309 | Sequence 2 from patent US 7671019 |
| GI:11545906 | GenBank | ADR93747.1 | 309 | Sequence 2 from patent US 7749503 |
| GI:11545906 | GenBank | AEW32427.1 | 309 | Sequence 2 from patent US 8071300 |
| GI:11545906 | GenBank | AIC56991.1 | 309 | FN3K, partial [synthetic construct] |
| GI:11545906 | GenBank | AIC62795.1 | 309 | FN3K, partial [synthetic construct] |
Related Sequences to LMP002852 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:11545906 | GenBank | AAQ02551.1 | 310 | fructosamine-3-kinase, partial [synthetic construct] |
| GI:11545906 | GenBank | EAW89820.1 | 455 | fructosamine 3 kinase, isoform CRA_b [Homo sapiens] |
| GI:11545906 | GenBank | JAA01006.1 | 309 | fructosamine 3 kinase [Pan troglodytes] |
| GI:11545906 | GenBank | JAA17594.1 | 309 | fructosamine 3 kinase [Pan troglodytes] |
| GI:11545906 | GenBank | JAA24825.1 | 309 | fructosamine 3 kinase [Pan troglodytes] |
| GI:11545906 | RefSeq | XP_003809018.1 | 309 | PREDICTED: fructosamine-3-kinase [Pan paniscus] |