Gene/Proteome Database (LMPD)

LMPD ID
LMP002856
Gene ID
67041
Species
Mus musculus (Mouse)
Gene Name
3-oxoacid CoA transferase 1
Gene Symbol
Oxct1
Synonyms
2610008O03Rik; Oxct; Oxct2a; Scot-s
Alternate Names
succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; 3-oxoacid CoA-transferase 1; 3-oxoacid-CoA transferase 1; succinyl-CoA:3-ketoacid CoA transferase; somatic-type succinyl CoA:3-oxoacid CoA-transferase; somatic-type succinyl-CoA:3-oxoacid CoA-transferase; succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial
Chromosome
15
Map Location
15 A1|15
EC Number
2.8.3.5

Proteins

succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial precursor
Refseq ID NP_077150
Protein GI 18266680
UniProt ID Q9D0K2
mRNA ID NM_024188
Length 520
RefSeq Status VALIDATED
MAALKLLSSGLRLGASARSSRGALHKGCVCYFSVSTRHHTKFYTDPVEAVKDIPNGATLLVGGFGLCGIPENLIGALLKTGVKDLTAVSNNAGVDNFGLGLLLRSKQIKRMISSYVGENAEFERQFLSGELEVELTPQGTLAERIRAGGAGVPAFYTSTGYGTLVQEGGSPIKYNKDGSVAIASKPREVREFNGQHFILEEAITGDFALVKAWKADRAGNVIFRKSARNFNLPMCKAAGTTVVEVEEIVDIGSFAPEDIHIPKIYVHRLIKGEKYEKRIERLSLRKEGDGKGKSGKPGGDVRERIIKRAALEFEDGMYANLGIGIPLLASNFISPNMTVHLQSENGVLGLGPYPLKDEADADLINAGKETVTVLPGASFFSSDESFAMIRGGHVNLTMLGAMQVSKYGDLANWMIPGKMVKGMGGAMDLVSSSKTKVVVTMEHSAKGNAHKIMEKCTLPLTGKQCVNRIITEKGVFDVDKKNGLTLIELWEGLTVDDIKKSTGCDFAVSPNLMPMQQIST
transit_peptide: 1..39 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q9D0K2.1) calculated_mol_wt: 4130 peptide sequence: MAALKLLSSGLRLGASARSSRGALHKGCVCYFSVSTRHH mat_peptide: 40..520 product: Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9D0K2.1) calculated_mol_wt: 51877 peptide sequence: TKFYTDPVEAVKDIPNGATLLVGGFGLCGIPENLIGALLKTGVKDLTAVSNNAGVDNFGLGLLLRSKQIKRMISSYVGENAEFERQFLSGELEVELTPQGTLAERIRAGGAGVPAFYTSTGYGTLVQEGGSPIKYNKDGSVAIASKPREVREFNGQHFILEEAITGDFALVKAWKADRAGNVIFRKSARNFNLPMCKAAGTTVVEVEEIVDIGSFAPEDIHIPKIYVHRLIKGEKYEKRIERLSLRKEGDGKGKSGKPGGDVRERIIKRAALEFEDGMYANLGIGIPLLASNFISPNMTVHLQSENGVLGLGPYPLKDEADADLINAGKETVTVLPGASFFSSDESFAMIRGGHVNLTMLGAMQVSKYGDLANWMIPGKMVKGMGGAMDLVSSSKTKVVVTMEHSAKGNAHKIMEKCTLPLTGKQCVNRIITEKGVFDVDKKNGLTLIELWEGLTVDDIKKSTGCDFAVSPNLMPMQQIST

Gene Information

Entrez Gene ID
67041
Gene Name
3-oxoacid CoA transferase 1
Gene Symbol
Oxct1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IDA:MGI C mitochondrion
GO:0008260 IDA:MGI F 3-oxoacid CoA-transferase activity
GO:0060612 IEA:Ensembl P adipose tissue development
GO:0007420 IEA:Ensembl P brain development
GO:0046950 IDA:MGI P cellular ketone body metabolic process
GO:0071229 IEA:Ensembl P cellular response to acid chemical
GO:0071333 IEA:Ensembl P cellular response to glucose stimulus
GO:0007507 IEA:Ensembl P heart development
GO:0046952 IMP:MGI P ketone body catabolic process
GO:0042182 IMP:MGI P ketone catabolic process
GO:0032024 IEA:Ensembl P positive regulation of insulin secretion
GO:0014823 IEA:Ensembl P response to activity
GO:0042493 IEA:Ensembl P response to drug
GO:0045471 IEA:Ensembl P response to ethanol
GO:0009725 IEA:Ensembl P response to hormone
GO:0007584 IEA:Ensembl P response to nutrient
GO:0042594 IEA:Ensembl P response to starvation

KEGG Pathway Links

KEGG Pathway ID Description
mmu00650 Butanoate metabolism
mmu00280 Valine, leucine and isoleucine degradation

REACTOME Pathway Links

REACTOME Pathway ID Description
5892877 Utilization of Ketone Bodies

Domain Information

InterPro Annotations

Accession Description
IPR012792 3-oxoacid CoA-transferase, subunit A
IPR012791 3-oxoacid CoA-transferase, subunit B
IPR014388 3-oxoacid_CoA-transferase
IPR004164 Coenzyme A transferase active site
IPR004163 Coenzyme A transferase binding site
IPR004165 Coenzyme A transferase family I

UniProt Annotations

Entry Information

Gene Name
3-oxoacid CoA transferase 1
Protein Entry
SCOT1_MOUSE
UniProt ID
Q9D0K2
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Succinyl-CoA + a 3-oxo acid = succinate + a 3- oxoacyl-CoA. {ECO:0000255|PROSITE-ProRule:PRU10034}.
Function Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). {ECO:0000250}.
Pathway Ketone metabolism; succinyl-CoA degradation; acetoacetyl- CoA from succinyl-CoA: step 1/1.
Similarity Belongs to the 3-oxoacid CoA-transferase family. {ECO:0000305}.
Subcellular Location Mitochondrion matrix {ECO:0000250}.
Subunit Homodimer. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002856 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18266680 RefSeq NP_077150 520 succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial precursor

Identical Sequences to LMP002856 proteins

Reference Database Accession Length Protein Name
GI:18266680 DBBJ BAC05524.1 520 succinyl CoA transferase [Mus musculus]
GI:18266680 DBBJ BAE30590.1 520 unnamed protein product [Mus musculus]
GI:18266680 DBBJ BAE39730.1 520 unnamed protein product [Mus musculus]
GI:18266680 GenBank AAH03422.1 520 3-oxoacid CoA transferase 1 [Mus musculus]
GI:18266680 GenBank EDL03395.1 520 3-oxoacid CoA transferase 1 [Mus musculus]
GI:18266680 SwissProt Q9D0K2.1 520 RecName: Full=Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; AltName: Full=3-oxoacid CoA-transferase 1; AltName: Full=Somatic-type succinyl-CoA:3-oxoacid CoA-transferase; Short=SCOT-s; Flags: Precursor [Mus musculus]

Related Sequences to LMP002856 proteins

Reference Database Accession Length Protein Name
GI:18266680 DBBJ BAE30619.1 520 unnamed protein product [Mus musculus]
GI:18266680 DBBJ BAE26941.1 520 unnamed protein product [Mus musculus]
GI:18266680 GenBank EDL75738.1 520 rCG50966 [Rattus norvegicus]
GI:18266680 GenBank AAI66478.1 520 Oxct1 protein [Rattus norvegicus]
GI:18266680 RefSeq NP_001121052.1 520 succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial precursor [Rattus norvegicus]
GI:18266680 SwissProt B2GV06.1 520 RecName: Full=Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; AltName: Full=3-oxoacid CoA-transferase 1; AltName: Full=Somatic-type succinyl-CoA:3-oxoacid CoA-transferase; Short=SCOT-s; Flags: Precursor [Rattus norvegicus]