Gene/Proteome Database (LMPD)
Proteins
| lysosomal thioesterase PPT2 precursor | |
|---|---|
| Refseq ID | NP_062314 |
| Protein GI | 9506985 |
| UniProt ID | O35448 |
| mRNA ID | NM_019441 |
| Length | 302 |
| RefSeq Status | VALIDATED |
| Protein sequence is identical to GI:698980054 (mRNA isoform) | |
| sig_peptide: 1..27 experiment: experimental evidence, no additional details recorded note: {ECO:0000255}; propagated from UniProtKB/Swiss-Prot (O35448.1) calculated_mol_wt: 3102 peptide sequence: MPGLWRQRLPSAWALLLLPFLPLLMPA mat_peptide: 28..302 product: Lysosomal thioesterase PPT2 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (O35448.1) calculated_mol_wt: 31283 peptide sequence: APAAHRGSYKPVIVVHGLFDSSYSFRHLLDYINETHTGTVVTVLDLFDGRESLRPLWEQVQGFREAVVPIMEKAPEGVHLICYSQGGLVCRALLSVMDNHNVDSFISLSSPQMGQYGDTDYLKWLFPTSMRSNLYRVCYSPWGQEFSICNYWHDPHHDDLYLNASSFLALINGERDHPNATAWRKNFLRVGRLVLIGGPDDGVITPWQSSFFGFYDANETVLEMEEQPVYLRDSFGLKTLLARGAIVRCPMAGISHTTWHSNRTLYDTCIEPWLS sig_peptide: 1..27 experiment: experimental evidence, no additional details recorded note: {ECO:0000255}; propagated from UniProtKB/Swiss-Prot (O35448.1) calculated_mol_wt: 3102 peptide sequence: MPGLWRQRLPSAWALLLLPFLPLLMPA mat_peptide: 28..302 product: Lysosomal thioesterase PPT2 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (O35448.1) calculated_mol_wt: 31283 peptide sequence: APAAHRGSYKPVIVVHGLFDSSYSFRHLLDYINETHTGTVVTVLDLFDGRESLRPLWEQVQGFREAVVPIMEKAPEGVHLICYSQGGLVCRALLSVMDNHNVDSFISLSSPQMGQYGDTDYLKWLFPTSMRSNLYRVCYSPWGQEFSICNYWHDPHHDDLYLNASSFLALINGERDHPNATAWRKNFLRVGRLVLIGGPDDGVITPWQSSFFGFYDANETVLEMEEQPVYLRDSFGLKTLLARGAIVRCPMAGISHTTWHSNRTLYDTCIEPWLS sig_peptide: 1..27 experiment: experimental evidence, no additional details recorded note: {ECO:0000255}; propagated from UniProtKB/Swiss-Prot (O35448.1) calculated_mol_wt: 3102 peptide sequence: MPGLWRQRLPSAWALLLLPFLPLLMPA mat_peptide: 28..302 product: Lysosomal thioesterase PPT2 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (O35448.1) calculated_mol_wt: 31283 peptide sequence: APAAHRGSYKPVIVVHGLFDSSYSFRHLLDYINETHTGTVVTVLDLFDGRESLRPLWEQVQGFREAVVPIMEKAPEGVHLICYSQGGLVCRALLSVMDNHNVDSFISLSSPQMGQYGDTDYLKWLFPTSMRSNLYRVCYSPWGQEFSICNYWHDPHHDDLYLNASSFLALINGERDHPNATAWRKNFLRVGRLVLIGGPDDGVITPWQSSFFGFYDANETVLEMEEQPVYLRDSFGLKTLLARGAIVRCPMAGISHTTWHSNRTLYDTCIEPWLS sig_peptide: 1..27 experiment: experimental evidence, no additional details recorded note: {ECO:0000255}; propagated from UniProtKB/Swiss-Prot (O35448.1) calculated_mol_wt: 3102 peptide sequence: MPGLWRQRLPSAWALLLLPFLPLLMPA mat_peptide: 28..302 product: Lysosomal thioesterase PPT2 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (O35448.1) calculated_mol_wt: 31283 peptide sequence: APAAHRGSYKPVIVVHGLFDSSYSFRHLLDYINETHTGTVVTVLDLFDGRESLRPLWEQVQGFREAVVPIMEKAPEGVHLICYSQGGLVCRALLSVMDNHNVDSFISLSSPQMGQYGDTDYLKWLFPTSMRSNLYRVCYSPWGQEFSICNYWHDPHHDDLYLNASSFLALINGERDHPNATAWRKNFLRVGRLVLIGGPDDGVITPWQSSFFGFYDANETVLEMEEQPVYLRDSFGLKTLLARGAIVRCPMAGISHTTWHSNRTLYDTCIEPWLS sig_peptide: 1..27 experiment: experimental evidence, no additional details recorded note: {ECO:0000255}; propagated from UniProtKB/Swiss-Prot (O35448.1) calculated_mol_wt: 3102 peptide sequence: MPGLWRQRLPSAWALLLLPFLPLLMPA mat_peptide: 28..302 product: Lysosomal thioesterase PPT2 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (O35448.1) calculated_mol_wt: 31283 peptide sequence: APAAHRGSYKPVIVVHGLFDSSYSFRHLLDYINETHTGTVVTVLDLFDGRESLRPLWEQVQGFREAVVPIMEKAPEGVHLICYSQGGLVCRALLSVMDNHNVDSFISLSSPQMGQYGDTDYLKWLFPTSMRSNLYRVCYSPWGQEFSICNYWHDPHHDDLYLNASSFLALINGERDHPNATAWRKNFLRVGRLVLIGGPDDGVITPWQSSFFGFYDANETVLEMEEQPVYLRDSFGLKTLLARGAIVRCPMAGISHTTWHSNRTLYDTCIEPWLS | |
Gene Information
Entrez Gene ID
Gene Name
palmitoyl-protein thioesterase 2
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0070062 | IEA:Ensembl | C | extracellular vesicular exosome |
| GO:0005764 | IBA:RefGenome | C | lysosome |
| GO:0008474 | IMP:MGI | F | palmitoyl-(protein) hydrolase activity |
| GO:0006464 | IEA:InterPro | P | cellular protein modification process |
| GO:0098734 | IMP:GOC | P | macromolecule depalmitoylation |
KEGG Pathway Links
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Disruption Phenotype | Mice are healthy at birth, but develop neuronal abnormalities, infiltration of bone marrow by macrophages and multinucleated giant cells, and splenomegaly caused by extramedullary hematopoiesis. Autofluorescent storage material is present in many cell types, particularly reticuloendothelial cells and neurons. {ECO:0000269|PubMed:11717424, ECO:0000269|PubMed:14528005}. |
| Function | Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S- thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins (By similarity). {ECO:0000250}. |
| Similarity | Belongs to the palmitoyl-protein thioesterase family. {ECO:0000305}. |
| Subcellular Location | Lysosome {ECO:0000269|PubMed:14528005}. |
| Tissue Specificity | Expressed throughout the brain, primarily in neurons, and at lower levels in glial cells. {ECO:0000269|PubMed:11717424, ECO:0000269|PubMed:14528005}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002873 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
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Identical Sequences to LMP002873 proteins
| Reference | Database | Accession | Length | Protein Name |
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Related Sequences to LMP002873 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|