Gene/Proteome Database (LMPD)

LMPD ID
LMP002888
Gene ID
11409
Species
Mus musculus (Mouse)
Gene Name
acyl-Coenzyme A dehydrogenase, short chain
Gene Symbol
Acads
Synonyms
AI196007; Bcd-1; Bcd1; Hdlq8; SCAD
Alternate Names
short-chain specific acyl-CoA dehydrogenase, mitochondrial; butyryl-CoA dehydrogenase
Chromosome
5
Map Location
5 F|5 55.99 cM
EC Number
1.3.8.1
Summary
This gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the Acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum at C(four)-CoA. In mice, deficiency of this gene has been linked to cold sensitivity and increased high-density lipoprotein levels. [provided by RefSeq, Nov 2012]
Orthologs
View orthologs and multiple alignments for Acads

Proteins

short-chain specific acyl-CoA dehydrogenase, mitochondrial precursor
Refseq ID NP_031409
Protein GI 31982522
UniProt ID Q07417
mRNA ID NM_007383
Length 412
RefSeq Status REVIEWED
MAAALLARARGPLRRALGVRDWRRLHTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDREHLFPTAQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEISRACASTGVIMSVNNSLYLGPILKFGSAQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRNAFGAPLTKLQNIQFKLADMALALESARLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLLRSYRS
transit_peptide: 1..24 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q07417.2) calculated_mol_wt: 2733 peptide sequence: MAAALLARARGPLRRALGVRDWRR mat_peptide: 25..412 product: Short-chain specific acyl-CoA dehydrogenase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q07417.2) calculated_mol_wt: 42175 peptide sequence: LHTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDREHLFPTAQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEISRACASTGVIMSVNNSLYLGPILKFGSAQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRNAFGAPLTKLQNIQFKLADMALALESARLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLLRSYRS

Gene Information

Entrez Gene ID
11409
Gene Name
acyl-Coenzyme A dehydrogenase, short chain
Gene Symbol
Acads
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0031966 IEA:Ensembl C mitochondrial membrane
GO:0005739 IDA:MGI C mitochondrion
GO:0005634 IEA:Ensembl C nucleus
GO:0003995 IEA:InterPro F acyl-CoA dehydrogenase activity
GO:0004085 IEA:UniProtKB-EC F butyryl-CoA dehydrogenase activity
GO:0000062 IEA:Ensembl F fatty-acyl-CoA binding
GO:0050660 IEA:InterPro F flavin adenine dinucleotide binding
GO:0046359 IEA:Ensembl P butyrate catabolic process
GO:0033539 IEA:Ensembl P fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0051289 IEA:Ensembl P protein homotetramerization
GO:0051384 IEA:Ensembl P response to glucocorticoid
GO:0042594 IEA:Ensembl P response to starvation

KEGG Pathway Links

KEGG Pathway ID Description
mmu01200 Carbon metabolism
mmu00071 Fatty acid degradation

REACTOME Pathway Links

REACTOME Pathway ID Description
5893011 Beta oxidation of hexanoyl-CoA to butanoyl-CoA

Domain Information

InterPro Annotations

Accession Description
IPR006089 Acyl-CoA dehydrogenase, conserved site
IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain
IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain

UniProt Annotations

Entry Information

Gene Name
acyl-Coenzyme A dehydrogenase, short chain
Protein Entry
ACADS_MOUSE
UniProt ID
Q07417
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Butanoyl-CoA + electron-transfer flavoprotein = 2-butenoyl-CoA + reduced electron-transfer flavoprotein.
Cofactor Name=FAD; Xref=ChEBI:CHEBI:57692;
Miscellaneous A number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.
Pathway Lipid metabolism; mitochondrial fatty acid beta- oxidation.
Similarity Belongs to the acyl-CoA dehydrogenase family. {ECO:0000305}.
Subcellular Location Mitochondrion matrix.
Subunit Homotetramer.

Identical and Related Proteins

Unique RefSeq proteins for LMP002888 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31982522 RefSeq NP_031409 412 short-chain specific acyl-CoA dehydrogenase, mitochondrial precursor

Identical Sequences to LMP002888 proteins

Reference Database Accession Length Protein Name
GI:31982522 DBBJ BAE41170.1 412 unnamed protein product [Mus musculus]
GI:31982522 DBBJ BAE33217.1 412 unnamed protein product [Mus musculus]
GI:31982522 GenBank AAH16259.1 412 Acyl-Coenzyme A dehydrogenase, short chain [Mus musculus]
GI:31982522 GenBank EDL19883.1 412 acyl-Coenzyme A dehydrogenase, short chain, isoform CRA_a [Mus musculus]
GI:31982522 SwissProt Q07417.2 412 RecName: Full=Short-chain specific acyl-CoA dehydrogenase, mitochondrial; Short=SCAD; AltName: Full=Butyryl-CoA dehydrogenase; Flags: Precursor [Mus musculus]

Related Sequences to LMP002888 proteins

Reference Database Accession Length Protein Name
GI:31982522 GenBank AAA16714.1 412 short chain acyl-CoA dehydrogenase [Mus musculus]
GI:31982522 GenBank AEQ84590.1 412 Sequence 84 from patent US 8039587
GI:31982522 GenBank AEU53453.1 412 Sequence 84 from patent US 8062891
GI:31982522 GenBank AGO72406.1 412 Sequence 84 from patent US 8470972
GI:31982522 GenBank AGU32397.1 412 Sequence 84 from patent US 8507277
GI:31982522 GenBank AGX48301.1 412 Sequence 84 from patent US 8541550