Gene/Proteome Database (LMPD)

LMPD ID
LMP002889
Gene ID
12904
Species
Mus musculus (Mouse)
Gene Name
cellular retinoic acid binding protein II
Gene Symbol
Crabp2
Synonyms
AI893628; Crabp-2; CrabpII
Alternate Names
cellular retinoic acid-binding protein 2; CRABP-II; cellular retinoic acid-binding protein II
Chromosome
3
Map Location
3F1|3

Proteins

cellular retinoic acid-binding protein 2
Refseq ID NP_031785
Protein GI 33469075
UniProt ID P22935
mRNA ID NM_007759
Length 138
RefSeq Status PROVISIONAL
MPNFSGNWKIIRSENFEEMLKALGVNMMMRKIAVAAASKPAVEIKQENDTFYIKTSTTVRTTEINFKIGEEFEEQTVDGRPCKSLVKWESGNKMVCEQRLLKGEGPKTSWSRELTNDGELILTMTADDVVCTRVYVRE

Gene Information

Entrez Gene ID
12904
Gene Name
cellular retinoic acid binding protein II
Gene Symbol
Crabp2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:UniProtKB C cytoplasm
GO:0005829 IEA:Ensembl C cytosol
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0016918 IEA:UniProtKB-KW F retinal binding
GO:0001972 IDA:MGI F retinoic acid binding
GO:0019841 IEA:UniProtKB-KW F retinol binding
GO:0005215 IEA:InterPro F transporter activity
GO:0035115 IMP:MGI P embryonic forelimb morphogenesis
GO:0002138 IEA:Ensembl P retinoic acid biosynthetic process
GO:0042573 IDA:MGI P retinoic acid metabolic process

REACTOME Pathway Links

REACTOME Pathway ID Description
5892977 Import of palmitoyl-CoA into the mitochondrial matrix
5892778 Pyruvate metabolism
5893557 Regulation of pyruvate dehydrogenase (PDH) complex

Domain Information

InterPro Annotations

Accession Description
IPR012674 Calycin
IPR011038 Calycin-like
IPR000463 Cytosolic fatty-acid binding
IPR000566 Lipocalin/cytosolic fatty-acid binding domain

UniProt Annotations

Entry Information

Gene Name
cellular retinoic acid binding protein II
Protein Entry
RABP2_MOUSE
UniProt ID
P22935
Species
Mouse

Comments

Comment Type Description
Domain Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. {ECO:0000250}.
Function Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors. {ECO:0000269|PubMed:10490651}.
Induction By retinoic acid.
Ptm Sumoylated in response to retinoic acid binding, sumoylation is critical for dissociation from ER and subsequent nuclear translocation.
Similarity Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:10490651}. Endoplasmic reticulum {ECO:0000250}. Nucleus {ECO:0000269|PubMed:10490651}. Note=Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.
Subunit Interacts with importin alpha (By similarity). Interacts with RXR and RARA. {ECO:0000250}.
Tissue Specificity Embryo and skin of adult mouse.

Identical and Related Proteins

Unique RefSeq proteins for LMP002889 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
33469075 RefSeq NP_031785 138 cellular retinoic acid-binding protein 2

Identical Sequences to LMP002889 proteins

Reference Database Accession Length Protein Name
GI:33469075 GenBank AAA37452.1 138 cellular retinoic acid binding protein type II, partial [Mus musculus domesticus]
GI:33469075 GenBank AAA37454.1 138 cellular retinoic acid-binding protein [Mus musculus]
GI:33469075 GenBank AAE06124.1 138 Sequence 12 from patent US 5871909
GI:33469075 GenBank AAH18397.1 138 Cellular retinoic acid binding protein II [Mus musculus]
GI:33469075 GenBank EDL15326.1 138 cellular retinoic acid binding protein II, isoform CRA_a [Mus musculus]
GI:33469075 pat US 138 Sequence 12 from patent US 5654137

Related Sequences to LMP002889 proteins

Reference Database Accession Length Protein Name
GI:33469075 GenBank AAA80225.1 139 cellular retinoic acid-binding protein II [Rattus norvegicus]
GI:33469075 RefSeq NP_058940.1 139 cellular retinoic acid-binding protein 2 [Rattus norvegicus]
GI:33469075 RefSeq XP_003749365.1 139 PREDICTED: cellular retinoic acid-binding protein 2 isoform X2 [Rattus norvegicus]
GI:33469075 RefSeq XP_006214655.1 138 PREDICTED: cellular retinoic acid-binding protein 2 [Vicugna pacos]
GI:33469075 RefSeq XP_006895811.1 138 PREDICTED: cellular retinoic acid-binding protein 2 [Elephantulus edwardii]
GI:33469075 SwissProt P51673.2 139 RecName: Full=Cellular retinoic acid-binding protein 2; AltName: Full=Cellular retinoic acid-binding protein II; Short=CRABP-II [Rattus norvegicus]