Gene/Proteome Database (LMPD)

LMPD ID
LMP002919
Gene ID
14466
Species
Mus musculus (Mouse)
Gene Name
glucosidase, beta, acid
Gene Symbol
Gba
Synonyms
GBA1; GC; GCase; GLUC; betaGC
Alternate Names
glucosylceramidase; glucocerebrosidase; acid beta glucosidase; beta-glucocerebrosidase; D-glucosyl-N-acylsphingosine glucohydrolase
Chromosome
3
Map Location
3 F1|3 39.01 cM
EC Number
3.2.1.45

Proteins

glucosylceramidase precursor
Refseq ID NP_001070879
Protein GI 116734815
UniProt ID P17439
mRNA ID NM_001077411
Length 515
RefSeq Status VALIDATED
MAARLIGFFLFQAVSWAYGAQPCIPKSFGYSSVVCVCNASYCDSLDPVTLPALGTFSRYESTRRGRRMELSVGAIQANRTGTGLLLTLQPEKKFQKVKGFGGAMTDATALNILALSPPTQKLLLRSYFSTNGIEYNIIRVPMASCDFSIRVYTYADTPNDFQLSNFSLPEEDTKLKIPLIHQALKMSSRPISLFASPWTSPTWLKTNGRVNGKGSLKGQPGDIFHQTWANYFVKFLDAYAKYGLRFWAVTAENEPTAGLFTGYPFQCLGFTPEHQRDFISRDLGPALANSSHDVKLLMLDDQRLLLPRWAEVVLSDPEAAKYVHGIAVHWYMDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVTGWTDWNLALNPEGGPNWVRNFVDSPIIVDIPKDAFYKQPMFYHLGHFSKFIPEGSQRVALVASESTDLETVALLRPDGSAVVVVLNRSSEDVPLTISDPDLGFLETVSPGYSIHTYLWRRQ
glucosylceramidase precursor
Refseq ID NP_032120
Protein GI 6679955
UniProt ID P17439
mRNA ID NM_008094
Length 515
RefSeq Status VALIDATED
Protein sequence is identical to GI:116734815 (mRNA isoform)
sig_peptide: 1..19 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2149 peptide sequence: MAARLIGFFLFQAVSWAYG mat_peptide: 20..515 product: Glucosylceramidase experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P17439.1) calculated_mol_wt: 55492 peptide sequence: AQPCIPKSFGYSSVVCVCNASYCDSLDPVTLPALGTFSRYESTRRGRRMELSVGAIQANRTGTGLLLTLQPEKKFQKVKGFGGAMTDATALNILALSPPTQKLLLRSYFSTNGIEYNIIRVPMASCDFSIRVYTYADTPNDFQLSNFSLPEEDTKLKIPLIHQALKMSSRPISLFASPWTSPTWLKTNGRVNGKGSLKGQPGDIFHQTWANYFVKFLDAYAKYGLRFWAVTAENEPTAGLFTGYPFQCLGFTPEHQRDFISRDLGPALANSSHDVKLLMLDDQRLLLPRWAEVVLSDPEAAKYVHGIAVHWYMDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVTGWTDWNLALNPEGGPNWVRNFVDSPIIVDIPKDAFYKQPMFYHLGHFSKFIPEGSQRVALVASESTDLETVALLRPDGSAVVVVLNRSSEDVPLTISDPDLGFLETVSPGYSIHTYLWRRQ sig_peptide: 1..19 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2149 peptide sequence: MAARLIGFFLFQAVSWAYG mat_peptide: 20..515 product: Glucosylceramidase experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P17439.1) calculated_mol_wt: 55492 peptide sequence: AQPCIPKSFGYSSVVCVCNASYCDSLDPVTLPALGTFSRYESTRRGRRMELSVGAIQANRTGTGLLLTLQPEKKFQKVKGFGGAMTDATALNILALSPPTQKLLLRSYFSTNGIEYNIIRVPMASCDFSIRVYTYADTPNDFQLSNFSLPEEDTKLKIPLIHQALKMSSRPISLFASPWTSPTWLKTNGRVNGKGSLKGQPGDIFHQTWANYFVKFLDAYAKYGLRFWAVTAENEPTAGLFTGYPFQCLGFTPEHQRDFISRDLGPALANSSHDVKLLMLDDQRLLLPRWAEVVLSDPEAAKYVHGIAVHWYMDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVTGWTDWNLALNPEGGPNWVRNFVDSPIIVDIPKDAFYKQPMFYHLGHFSKFIPEGSQRVALVASESTDLETVALLRPDGSAVVVVLNRSSEDVPLTISDPDLGFLETVSPGYSIHTYLWRRQ

Gene Information

Entrez Gene ID
14466
Gene Name
glucosidase, beta, acid
Gene Symbol
Gba
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0043202 IDA:BHF-UCL C lysosomal lumen
GO:0005765 IDA:BHF-UCL C lysosomal membrane
GO:0004348 IEA:UniProtKB-EC F glucosylceramidase activity
GO:0005102 IPI:BHF-UCL F receptor binding
GO:0005975 IEA:InterPro P carbohydrate metabolic process
GO:0071356 IEA:Ensembl P cellular response to tumor necrosis factor
GO:0046513 IEA:Ensembl P ceramide biosynthetic process
GO:0006680 IEA:Ensembl P glucosylceramide catabolic process
GO:0032715 IEA:Ensembl P negative regulation of interleukin-6 production
GO:0043407 IEA:Ensembl P negative regulation of MAP kinase activity
GO:0035307 IEA:Ensembl P positive regulation of protein dephosphorylation
GO:0033561 IEA:Ensembl P regulation of water loss via skin
GO:0043627 IEA:Ensembl P response to estrogen
GO:0051384 IEA:Ensembl P response to glucocorticoid
GO:0009268 IEA:Ensembl P response to pH
GO:0033574 IEA:Ensembl P response to testosterone
GO:0097066 IEA:Ensembl P response to thyroid hormone
GO:0043589 IEA:Ensembl P skin morphogenesis
GO:0046512 IEA:Ensembl P sphingosine biosynthetic process
GO:0023021 IEA:Ensembl P termination of signal transduction

KEGG Pathway Links

KEGG Pathway ID Description
mmu04142 Lysosome
mmu01100 Metabolic pathways
mmu00600 Sphingolipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5893995 Glycosphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR013781 Glycoside hydrolase, catalytic domain
IPR001139 Glycoside hydrolase, family 30
IPR017853 Glycoside hydrolase superfamily
IPR013780 Glycosyl hydrolase, family 13, all-beta

UniProt Annotations

Entry Information

Gene Name
glucosidase, beta, acid
Protein Entry
GLCM_MOUSE
UniProt ID
P17439
Species
Mouse

Comments

Comment Type Description
Catalytic Activity D-glucosyl-N-acylsphingosine + H(2)O = D- glucose + N-acylsphingosine.
Interaction Q14108:SCARB2 (xeno); NbExp=1; IntAct=EBI-1564504, EBI-1564650; O35114:Scarb2; NbExp=1; IntAct=EBI-1564504, EBI-1564519;
Similarity Belongs to the glycosyl hydrolase 30 family. {ECO:0000305}.
Subcellular Location Lysosome membrane; Peripheral membrane protein. Note=Targeting to lysosomes occurs through an alternative MPR-independent mechanism via SCARB2. {ECO:0000250}.
Subunit Interacts with SCARB2. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002919 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
116734815 RefSeq NP_001070879 515 glucosylceramidase precursor

Identical Sequences to LMP002919 proteins

Reference Database Accession Length Protein Name
GI:116734815 DBBJ BAC38609.1 515 unnamed protein product [Mus musculus]
GI:116734815 GenBank AAA37671.1 515 glucocerebrosidase precursor (EC 3.2.1.45) [Mus musculus]
GI:116734815 GenBank AAH06663.1 515 Glucosidase, beta, acid [Mus musculus]
GI:116734815 GenBank AAM66757.1 515 glucocerebrosidase precursor [Mus musculus]
GI:116734815 GenBank EDL15230.1 515 glucosidase, beta, acid, isoform CRA_b [Mus musculus]
GI:116734815 RefSeq NP_032120.1 515 glucosylceramidase precursor [Mus musculus]

Related Sequences to LMP002919 proteins

Reference Database Accession Length Protein Name
GI:116734815 GenBank EDL15229.1 524 glucosidase, beta, acid, isoform CRA_a, partial [Mus musculus]
GI:116734815 GenBank EDM00662.1 515 rCG62590 [Rattus norvegicus]
GI:116734815 GenBank AAI66732.1 515 Gba protein [Rattus norvegicus]
GI:116734815 RefSeq NP_001121111.1 515 glucosylceramidase precursor [Rattus norvegicus]
GI:116734815 RefSeq XP_005367206.1 515 PREDICTED: glucosylceramidase [Microtus ochrogaster]
GI:116734815 RefSeq XP_006976406.1 515 PREDICTED: glucosylceramidase [Peromyscus maniculatus bairdii]