Gene/Proteome Database (LMPD)
LMPD ID
LMP002921
Gene ID
Species
Homo sapiens (Human)
Gene Name
inositol-trisphosphate 3-kinase A
Gene Symbol
Synonyms
IP3-3KA; IP3KA
Alternate Names
inositol-trisphosphate 3-kinase A; IP3K A; IP3 3-kinase A; insP 3-kinase A; inositol 1,4,5-trisphosphate 3-kinase A
Chromosome
15
Map Location
15q15.1
EC Number
2.7.1.127
Summary
Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]
Orthologs
Proteins
| inositol-trisphosphate 3-kinase A | |
|---|---|
| Refseq ID | NP_002211 |
| Protein GI | 4504789 |
| UniProt ID | P23677 |
| mRNA ID | NM_002220 |
| Length | 461 |
| RefSeq Status | REVIEWED |
| MTLPGGPTGMARPGGARPCSPGLERAPRRSVGELRLLFEARCAAVAAAAAAGEPRARGAKRRGGQVPNGLPRAPPAPVIPQLTVTAEEPDVPPTSPGPPERERDCLPAAGSSHLQQPRRLSTSSVSSTGSSSLLEDSEDDLLSDSESRSRGNVQLEAGEDVGQKNHWQKIRTMVNLPVISPFKKRYAWVQLAGHTGSFKAAGTSGLILKRCSEPERYCLARLMADALRGCVPAFHGVVERDGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARERPKLRKDMYKKMLAVDPEAPTEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGIKKADGSCSTDFKTTRSREQVLRVFEEFVQGDEEVLRRYLNRLQQIRDTLEVSEFFRRHEVIGSSLLFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEEGNREDGYLLGLDNLIGILASLAER | |
Gene Information
Entrez Gene ID
Gene Name
inositol-trisphosphate 3-kinase A
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005829 | TAS:Reactome | C | cytosol |
| GO:0043197 | IEA:Ensembl | C | dendritic spine |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0004683 | IEA:Ensembl | F | calmodulin-dependent protein kinase activity |
| GO:0008440 | TAS:ProtInc | F | inositol-1,4,5-trisphosphate 3-kinase activity |
| GO:0030036 | IEA:Ensembl | P | actin cytoskeleton organization |
| GO:0097062 | IEA:Ensembl | P | dendritic spine maintenance |
| GO:0006020 | IEA:Ensembl | P | inositol metabolic process |
| GO:0043647 | TAS:Reactome | P | inositol phosphate metabolic process |
| GO:0061003 | IEA:Ensembl | P | positive regulation of dendritic spine morphogenesis |
| GO:0048167 | IEA:Ensembl | P | regulation of synaptic plasticity |
| GO:0007165 | TAS:ProtInc | P | signal transduction |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa04020 | Calcium signaling pathway |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY-6362 | 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian) |
| PWY-6364 | D-myo-inositol (1,3,4)-trisphosphate biosynthesis |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_150312 | Synthesis of IP3 and IP4 in the cytosol |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR005522 | Inositol polyphosphate kinase |
UniProt Annotations
Entry Information
Gene Name
inositol-trisphosphate 3-kinase A
Protein Entry
IP3KA_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate. |
| Enzyme Regulation | IP3K is activated by calmodulin. |
| Similarity | Belongs to the inositol phosphokinase (IPK) family. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002921 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 4504789 | RefSeq | NP_002211 | 461 | inositol-trisphosphate 3-kinase A |
Identical Sequences to LMP002921 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4504789 | DBBJ | BAG73293.1 | 461 | inositol 1,4,5-trisphosphate 3-kinase A, partial [synthetic construct] |
| GI:4504789 | EMBL | CAA38700.1 | 461 | inositol 1,4,5-triphosphate 3-kinase [Homo sapiens] |
| GI:4504789 | GenBank | EAW92493.1 | 461 | inositol 1,4,5-trisphosphate 3-kinase A [Homo sapiens] |
| GI:4504789 | RefSeq | XP_003266802.1 | 461 | PREDICTED: inositol-trisphosphate 3-kinase A [Nomascus leucogenys] |
| GI:4504789 | SwissProt | P23677.1 | 461 | RecName: Full=Inositol-trisphosphate 3-kinase A; AltName: Full=Inositol 1,4,5-trisphosphate 3-kinase A; Short=IP3 3-kinase A; Short=IP3K A; Short=InsP 3-kinase A [Homo sapiens] |
Related Sequences to LMP002921 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4504789 | GenBank | AAH26331.1 | 461 | Inositol 1,4,5-trisphosphate 3-kinase A [Homo sapiens] |
| GI:4504789 | GenBank | AAX29875.1 | 462 | inositol 145-trisphosphate 3-kinase A, partial [synthetic construct] |
| GI:4504789 | GenBank | AAX42438.1 | 461 | inositol 145-trisphosphate 3-kinase A [synthetic construct] |
| GI:4504789 | GenBank | ACM85007.1 | 464 | Sequence 10505 from patent US 6812339 |
| GI:4504789 | RefSeq | XP_003900858.1 | 461 | PREDICTED: inositol-trisphosphate 3-kinase A [Papio anubis] |
| GI:4504789 | RefSeq | XP_005559304.1 | 461 | PREDICTED: inositol-trisphosphate 3-kinase A [Macaca fascicularis] |