Gene/Proteome Database (LMPD)

LMPD ID
LMP002929
Gene ID
18799
Species
Mus musculus (Mouse)
Gene Name
phospholipase C, delta 1
Gene Symbol
Plcd1
Synonyms
AW212592; C79986
Chromosome
9
Map Location
9 F3|9

Proteins

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform 1
Refseq ID NP_001280577
Protein GI 652698221
UniProt ID Q8R3B1
mRNA ID NM_001293648
Length 782
RefSeq Status VALIDATED
MQCLGVRSCRRGSVNRSRELYLQEQSRKVAALNGQRLGLQDDPDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRSPESQLFSIEDIQEVRMGHRTEGLEKFARDIPEDRCFSIVFKDQRNTLDLIAPSPADVQHWVQGLRKIIDRSGSMDQRQKLQHWIHSCLRKADKNKDNKMNFKEVKDFLKELNVQVDDSYARKIFRECDHSQTDSLEDEEIETFYRMLTQRAEIDRAFAEAAGSAETLSVEKLVTFLQHQQREEEAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRVYQDMNQPLSHYLVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCSLEQQRVMAHHLRAILGPMLLDQPLDGVTTSLPSPEQLKEKILLKGKKLGGLLPAGGENGPEATDVSDEDEAAEMEDEAVRSQVQHKPKEDKLKLVPELSDMVIYCKSVHFGGFSSPSTSGQAFYEMASFSESRALRLLQESGNSFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYVLKPAFLRDPDTTFNSRALTQGPWWAPKKLRVWIISGQQLPKVNKNKNSIVDPKVIVEIHGVGQDVASRQTAVITNNGFNPRWDTEFEFVVAVPDLALVRFMVEDYDSSSKNDFIGQSTIPWNSLKQGYRHVHLLSKNGDLHPSATLFVKISIQD
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform 2
Refseq ID NP_062650
Protein GI 9790167
UniProt ID Q8R3B1
mRNA ID NM_019676
Length 756
RefSeq Status VALIDATED
MDSGRDFLTLHGLQDDPDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRSPESQLFSIEDIQEVRMGHRTEGLEKFARDIPEDRCFSIVFKDQRNTLDLIAPSPADVQHWVQGLRKIIDRSGSMDQRQKLQHWIHSCLRKADKNKDNKMNFKEVKDFLKELNVQVDDSYARKIFRECDHSQTDSLEDEEIETFYRMLTQRAEIDRAFAEAAGSAETLSVEKLVTFLQHQQREEEAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRVYQDMNQPLSHYLVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCSLEQQRVMAHHLRAILGPMLLDQPLDGVTTSLPSPEQLKEKILLKGKKLGGLLPAGGENGPEATDVSDEDEAAEMEDEAVRSQVQHKPKEDKLKLVPELSDMVIYCKSVHFGGFSSPSTSGQAFYEMASFSESRALRLLQESGNSFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYVLKPAFLRDPDTTFNSRALTQGPWWAPKKLRVWIISGQQLPKVNKNKNSIVDPKVIVEIHGVGQDVASRQTAVITNNGFNPRWDTEFEFVVAVPDLALVRFMVEDYDSSSKNDFIGQSTIPWNSLKQGYRHVHLLSKNGDLHPSATLFVKISIQD

Gene Information

Entrez Gene ID
18799
Gene Name
phospholipase C, delta 1
Gene Symbol
Plcd1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:MGI C cytoplasm
GO:0005829 IDA:MGI C cytosol
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005509 IEA:InterPro F calcium ion binding
GO:0070300 IDA:MGI F phosphatidic acid binding
GO:1901981 IDA:MGI F phosphatidylinositol phosphate binding
GO:0004435 IEA:UniProtKB-EC F phosphatidylinositol phospholipase C activity
GO:0001786 IDA:MGI F phosphatidylserine binding
GO:0004629 IDA:MGI F phospholipase C activity
GO:0004871 IEA:UniProtKB-KW F signal transducer activity
GO:0001525 IGI:MGI P angiogenesis
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0060716 IGI:MGI P labyrinthine layer blood vessel development
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0042127 IGI:MGI P regulation of cell proliferation

KEGG Pathway Links

KEGG Pathway ID Description
ko04020 Calcium signaling pathway
mmu04020 Calcium signaling pathway
ko00562 Inositol phosphate metabolism
mmu00562 Inositol phosphate metabolism
M00130 Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
mmu01100 Metabolic pathways
ko04070 Phosphatidylinositol signaling system
mmu04070 Phosphatidylinositol signaling system
mmu04919 Thyroid hormone signaling pathway

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6351 D-myo-inositol (1,4,5)-trisphosphate biosynthesis
PWY-6367 D-myo-inositol-5-phosphate metabolism
PWY3DJ-219 PIP metabolism
LIPASYN-PWY phospholipases

REACTOME Pathway Links

REACTOME Pathway ID Description
5894026 Inositol phosphate metabolism
5892760 Metabolism
5894025 Synthesis of IP3 and IP4 in the cytosol

Domain Information

InterPro Annotations

Accession Description
IPR028391 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
IPR000008 C2 domain
IPR018247 EF-Hand 1, calcium-binding site
IPR002048 EF-hand domain
IPR011992 EF-hand domain pair
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR001192 Phosphoinositide phospholipase C family
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain

UniProt Annotations

Entry Information

Gene Name
phospholipase C, delta 1
Protein Entry
G5DDB7_MOUSE
UniProt ID
Q8R3B1
Species
Mouse

Comments

Comment Type Description
Catalytic Activity 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain. {ECO:0000250};
Disruption Phenotype Mice lacking Plcd1 and Plcd3 die between 11.5 and 13.5 dpc. They exhibit severe disruption of the normal labyrinth architecture in the placenta and decreased placental vascularization, as well as abnormal proliferation and apoptosis of trophoblasts in the labyrinth area. Furthermore, Plcd1 and Plcd3 double knockout embryos supplied with a normal placenta by the tetraploid aggregation method survive beyond 14.5 dpc, indicating that the embryonic lethality is caused by a defect in trophoblasts. {ECO:0000269|PubMed:16314520}.
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development. {ECO:0000269|PubMed:16314520}.
Similarity Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Similarity Contains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Similarity Contains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}.
Similarity Contains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}.
Similarity Contains 2 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}.
Tissue Specificity Highly expressed in brain, heart, lung, epididymis and testis. Detected at lower levels in kidney and skeletal muscle. {ECO:0000269|PubMed:10425196}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002929 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
652698221 RefSeq NP_001280577 782 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform 1
9790167 RefSeq NP_062650 756 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform 2

Identical Sequences to LMP002929 proteins

Reference Database Accession Length Protein Name
GI:9790167 DBBJ BAC26096.1 756 unnamed protein product [Mus musculus]
GI:9790167 DBBJ BAC38671.1 756 unnamed protein product [Mus musculus]
GI:9790167 GenBank ABK42330.1 756 PLC-delta1 [synthetic construct]
GI:9790167 GenBank EDL09242.1 756 phospholipase C, delta 1, isoform CRA_a [Mus musculus]
GI:9790167 GenBank ABW60474.1 756 Sequence 117 from patent US 7276593
GI:652698221 GenBank AEP68051.1 782 phospholipase C delta 1 Lf [Mus musculus]
GI:9790167 SwissProt Q8R3B1.2 756 RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; AltName: Full=Phosphoinositide phospholipase C-delta-1; AltName: Full=Phospholipase C-delta-1; Short=PLC-delta-1 [Mus musculus]

Related Sequences to LMP002929 proteins

Reference Database Accession Length Protein Name
GI:652698221 DBBJ BAC26096.1 756 unnamed protein product [Mus musculus]
GI:652698221 DBBJ BAC38671.1 756 unnamed protein product [Mus musculus]
GI:9790167 EMBL CBU87806.1 756 unnamed protein product [Rattus sp.]
GI:652698221 GenBank AAD32616.1 756 phospholipase C delta-1 [Mus musculus]
GI:9790167 GenBank AAH25798.1 756 Phospholipase C, delta 1 [Mus musculus]
GI:9790167 GenBank AAS36217.1 744 Sequence 5 from patent US 6689598
GI:9790167 GenBank ABH92515.1 744 Sequence 5 from patent US 7060481
GI:652698221 GenBank ABW60474.1 756 Sequence 117 from patent US 7276593
GI:9790167 GenBank AEP68051.1 782 phospholipase C delta 1 Lf [Mus musculus]
GI:652698221 RefSeq NP_062650.1 756 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform 2 [Mus musculus]
GI:9790167 RefSeq NP_001280577.1 782 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform 1 [Mus musculus]
GI:652698221 SwissProt Q8R3B1.2 756 RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; AltName: Full=Phosphoinositide phospholipase C-delta-1; AltName: Full=Phospholipase C-delta-1; Short=PLC-delta-1 [Mus musculus]