Gene/Proteome Database (LMPD)

LMPD ID
LMP002935
Gene ID
10857
Species
Homo sapiens (Human)
Gene Name
progesterone receptor membrane component 1
Gene Symbol
PGRMC1
Synonyms
HPR6.6; MPR
Alternate Names
membrane-associated progesterone receptor component 1; progesterone binding protein
Chromosome
X
Map Location
Xq22-q24
Summary
This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney. [provided by RefSeq, Mar 2010]
Orthologs
View orthologs and multiple alignments for PGRMC1

Proteins

membrane-associated progesterone receptor component 1 isoform 1
Refseq ID NP_006658
Protein GI 5729875
UniProt ID O00264
mRNA ID NM_006667
Length 195
RefSeq Status REVIEWED
MAAEDVVATGADPSDLESGGLLHEIFTSPLNLLLLGLCIFLLYKIVRGDQPAASGDSDDDEPPPLPRLKRRDFTPAELRRFDGVQDPRILMAINGKVFDVTKGRKFYGPEGPYGVFAGRDASRGLATFCLDKEALKDEYDDLSDLTAAQQETLSDWESQFTFKYHHVGKLLKEGEEPTVYSDEEEPKDESARKND
membrane-associated progesterone receptor component 1 isoform 2
Refseq ID NP_001269550
Protein GI 544063461
UniProt ID O00264
mRNA ID NM_001282621
Length 143
RefSeq Status REVIEWED
MAAEDVVATGADPSDLESGGLLHEIFTSPLNLLLLGLCIFLLYKIVRGDQPAASGDSDDDEPPPLPRLKRRDFTPAELRRFDGVQDPRILMAINGKVFDVTKGRKFYGPVKYHHVGKLLKEGEEPTVYSDEEEPKDESARKND

Gene Information

Entrez Gene ID
10857
Gene Name
progesterone receptor membrane component 1
Gene Symbol
PGRMC1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:HPA C endoplasmic reticulum
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016020 IDA:UniProtKB C membrane
GO:0005730 IDA:HPA C nucleolus
GO:0020037 IEA:InterPro F heme binding
GO:0005496 TAS:ProtInc F steroid binding
GO:0007411 IEA:Ensembl P axon guidance

Domain Information

InterPro Annotations

Accession Description
IPR001199 Cytochrome b5-like heme/steroid binding domain

UniProt Annotations

Entry Information

Gene Name
progesterone receptor membrane component 1
Protein Entry
PGRC1_HUMAN
UniProt ID
O00264
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O00264-1; Sequence=Displayed; Name=2; IsoId=O00264-2; Sequence=VSP_054710; Note=No experimental confirmation available.;
Domain The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 107 and 131.
Function Receptor for progesterone.
Interaction P00181:CYP2C2 (xeno); NbExp=6; IntAct=EBI-1045534, EBI-4320576; P16435:POR; NbExp=5; IntAct=EBI-1045534, EBI-726554;
Similarity Belongs to the cytochrome b5 family. MAPR subfamily.
Similarity Contains 1 cytochrome b5 heme-binding domain.
Subcellular Location Microsome membrane ; Single- pass membrane protein . Endoplasmic reticulum membrane ; Single-pass membrane protein .
Tissue Specificity Widely expressed, with highest expression in liver and kidney.

Identical and Related Proteins

Unique RefSeq proteins for LMP002935 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
5729875 RefSeq NP_006658 195 membrane-associated progesterone receptor component 1 isoform 1
544063461 RefSeq NP_001269550 143 membrane-associated progesterone receptor component 1 isoform 2

Identical Sequences to LMP002935 proteins

Reference Database Accession Length Protein Name
GI:544063461 DBBJ BAH11549.1 143 unnamed protein product [Homo sapiens]
GI:544063461 GenBank EAW89881.1 143 progesterone receptor membrane component 1, isoform CRA_c [Homo sapiens]
GI:5729875 GenBank AFQ84298.1 195 Sequence 3 from patent US 8252532
GI:5729875 GenBank JAA05176.1 195 progesterone receptor membrane component 1 [Pan troglodytes]
GI:5729875 GenBank JAA19151.1 195 progesterone receptor membrane component 1 [Pan troglodytes]
GI:5729875 GenBank JAA26418.1 195 progesterone receptor membrane component 1 [Pan troglodytes]
GI:5729875 GenBank JAA40504.1 195 progesterone receptor membrane component 1 [Pan troglodytes]
GI:544063461 RefSeq XP_001135502.1 143 PREDICTED: membrane-associated progesterone receptor component 1 [Pan troglodytes]
GI:5729875 RefSeq XP_003812676.1 195 PREDICTED: membrane-associated progesterone receptor component 1 [Pan paniscus]

Related Sequences to LMP002935 proteins

Reference Database Accession Length Protein Name
GI:5729875 EMBL CAH89877.1 195 hypothetical protein [Pongo abelii]
GI:5729875 RefSeq NP_001127207.1 195 membrane-associated progesterone receptor component 1 [Pongo abelii]
GI:544063461 RefSeq XP_001100639.2 143 PREDICTED: membrane-associated progesterone receptor component 1-like isoform 1 [Macaca mulatta]
GI:5729875 RefSeq XP_003262293.1 195 PREDICTED: membrane-associated progesterone receptor component 1 isoform 1 [Nomascus leucogenys]
GI:5729875 RefSeq XP_004092549.1 195 PREDICTED: membrane-associated progesterone receptor component 1 isoform 2 [Nomascus leucogenys]
GI:544063461 RefSeq XP_005083192.1 143 PREDICTED: membrane-associated progesterone receptor component 1 isoform X2 [Mesocricetus auratus]
GI:544063461 RefSeq XP_005673922.1 142 PREDICTED: membrane-associated progesterone receptor component 1 isoform X1 [Sus scrofa]
GI:544063461 RefSeq XP_006208878.1 142 PREDICTED: membrane-associated progesterone receptor component 1 isoform X2 [Vicugna pacos]
GI:544063461 RefSeq XP_007465514.1 142 PREDICTED: membrane-associated progesterone receptor component 1 isoform X2 [Lipotes vexillifer]
GI:544063461 RefSeq XP_007951538.1 143 PREDICTED: membrane-associated progesterone receptor component 1 isoform X2 [Orycteropus afer afer]
GI:5729875 RefSeq XP_010374625.1 195 PREDICTED: membrane-associated progesterone receptor component 1 [Rhinopithecus roxellana]
GI:5729875 SwissProt Q5RED0.3 195 RecName: Full=Membrane-associated progesterone receptor component 1 [Pongo abelii]