Gene/Proteome Database (LMPD)
LMPD ID
LMP002938
Gene ID
Species
Mus musculus (Mouse)
Gene Name
sphingosine-1-phosphate receptor 4
Gene Symbol
Synonyms
Edg6; Lpc1; S1p4
Alternate Names
sphingosine 1-phosphate receptor 4; S1p receptor 4; S1P receptor Edg-6; lysophospholipid receptor C1; sphingosine 1-phosphate receptor Edg-6; endothelial differentiation G-protein coupled receptor 6; endothelial differentiation G-protein-coupled receptor 6
Chromosome
10
Map Location
10 C1|10
Summary
This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for the lysophospholipid sphingosine 1-phosphate. The encoded protein is one of the predominant sphingosine 1-phosphate G-protein coupled receptors expressed in T cells, and it plays a role in suppression of T cell proliferation, generation of cytokines, and potentially other aspects of immune activation. [provided by RefSeq, Feb 2010]
Orthologs
Proteins
| sphingosine 1-phosphate receptor 4 | |
|---|---|
| Refseq ID | NP_034232 |
| Protein GI | 6753718 |
| UniProt ID | Q9Z0L1 |
| mRNA ID | NM_010102 |
| Length | 386 |
| RefSeq Status | REVIEWED |
| MNISTWSTLVTPESCHRLAASGHSLLIVLHYNHSGRLASRGGSEDGGGLGMLRGPSVAAGCLVVLENAMVLAAIAIYMRSRRWVYYCLLNITLSDLLTGLAYVVNVLLSGTRTFQLSPVHWFLREGLLFMALAASTFSLLFTAGERFATMVRVAESGATKTSRVYGCIGLCWLLAAILGLLPLLGWNCVCAFPRCSSLLPLYSKGYVLFCVVVFALILVAILSLYGAIFRVVRANGQKSPRPPARRKSRRLLNTVLMILVAFVVCWGPLFGLLLADIFGSNVWAQEYLRGMDWILALAVFNSAINPLIYSFRSREVQRAVLAFLCCGCLWLGLRGPGDCLTRITEAHSGASTTDSSLRPRDSFRTSRSLSFRMREPLSSISSVRST | |
Gene Information
Entrez Gene ID
Gene Name
sphingosine-1-phosphate receptor 4
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005887 | TAS:MGI | C | integral component of plasma membrane |
| GO:0004930 | TAS:MGI | F | G-protein coupled receptor activity |
| GO:0038036 | IEA:InterPro | F | sphingosine-1-phosphate receptor activity |
| GO:0007189 | IDA:MGI | P | adenylate cyclase-activating G-protein coupled receptor signaling pathway |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| mmu04068 | FoxO signaling pathway |
REACTOME Pathway Links
Domain Information
UniProt Annotations
Entry Information
Gene Name
sphingosine-1-phosphate receptor 4
Protein Entry
S1PR4_MOUSE
UniProt ID
Species
Mouse
Comments
| Comment Type | Description |
|---|---|
| Function | Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes (By similarity). {ECO:0000250}. |
| Similarity | Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Specifically expressed in fetal and adult lymphoid and hematopoietic tissue. Expressed in lung, spleen, thymus and lymph node but absent in other non-lymphatic tissue. Coexpressed with GNA15 at the same relative levels in all tissues examined, with the highest levels in adult spleen and lung. {ECO:0000269|PubMed:12401211}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002938 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 6753718 | RefSeq | NP_034232 | 386 | sphingosine 1-phosphate receptor 4 |
Identical Sequences to LMP002938 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6753718 | DBBJ | BAE32458.1 | 386 | unnamed protein product [Mus musculus] |
| GI:6753718 | EMBL | CAA06847.1 | 386 | G protein-coupled receptor [Mus musculus] |
| GI:6753718 | GenBank | AAI07001.1 | 386 | Sphingosine-1-phosphate receptor 4 [Mus musculus] |
| GI:6753718 | GenBank | EDL31402.1 | 386 | endothelial differentiation, G-protein-coupled receptor 6 [Mus musculus] |
| GI:6753718 | SwissProt | Q9Z0L1.1 | 386 | RecName: Full=Sphingosine 1-phosphate receptor 4; Short=S1P receptor 4; Short=S1P4; AltName: Full=Endothelial differentiation G-protein coupled receptor 6; AltName: Full=Lysophospholipid receptor C1; AltName: Full=Sphingosine 1-phosphate receptor Edg-6; Short=S1P receptor Edg-6 [Mus musculus] |
Related Sequences to LMP002938 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6753718 | EMBL | CAD33254.1 | 386 | sphingosine-1-phosphate G protein coupled receptor [Mus musculus] |
| GI:6753718 | GenBank | EDL89144.1 | 413 | endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 6 (predicted) [Rattus norvegicus] |
| GI:6753718 | GenBank | EGW03111.1 | 379 | Sphingosine 1-phosphate receptor 4 [Cricetulus griseus] |
| GI:6753718 | RefSeq | NP_001101545.1 | 413 | sphingosine 1-phosphate receptor 4 [Rattus norvegicus] |
| GI:6753718 | RefSeq | XP_005083303.1 | 385 | PREDICTED: sphingosine 1-phosphate receptor 4 [Mesocricetus auratus] |
| GI:6753718 | RefSeq | XP_006978182.1 | 379 | PREDICTED: sphingosine 1-phosphate receptor 4 [Peromyscus maniculatus bairdii] |