Gene/Proteome Database (LMPD)

LMPD ID
LMP002941
Gene ID
54578
Species
Homo sapiens (Human)
Gene Name
UDP glucuronosyltransferase 1 family, polypeptide A6
Gene Symbol
UGT1A6
Synonyms
GNT1; HLUGP; HLUGP1; UDPGT; UDPGT 1-6; UGT1; UGT1A6S; UGT1F
Alternate Names
UDP-glucuronosyltransferase 1-6; UGT-1F; UGT1*6; UGT1.6; UGT1-06; UDP-glucuronosyltransferase 1-F; UDP-glucuronosyltransferase 1A6; phenol-metabolizing UDP-glucuronosyltransferase; UDP glycosyltransferase 1 family, polypeptide A6; UDP-glucuronosyltransferase 1 family polypeptide A6s
Chromosome
2
Map Location
2q37
EC Number
2.4.1.17
Summary
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for UGT1A6

Proteins

UDP-glucuronosyltransferase 1-6 isoform 1 precursor
Refseq ID NP_001063
Protein GI 45827765
UniProt ID P19224
mRNA ID NM_001072
Length 532
RefSeq Status REVIEWED
MACLLRSFQRISAGVFFLALWGMVVGDKLLVVPQDGSHWLSMKDIVEVLSDRGHEIVVVVPEVNLLLKESKYYTRKIYPVPYDQEELKNRYQSFGNNHFAERSFLTAPQTEYRNNMIVIGLYFINCQSLLQDRDTLNFFKESKFDALFTDPALPCGVILAEYLGLPSVYLFRGFPCSLEHTFSRSPDPVSYIPRCYTKFSDHMTFSQRVANFLVNLLEPYLFYCLFSKYEELASAVLKRDVDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCKKRKDLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
UDP-glucuronosyltransferase 1-6 isoform 2
Refseq ID NP_995584
Protein GI 45827767
UniProt ID Q5DT01
mRNA ID NM_205862
Length 265
RefSeq Status REVIEWED
MPNMVFIGGINCKKRKDLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
sig_peptide: 1..26 calculated_mol_wt: 2874 peptide sequence: MACLLRSFQRISAGVFFLALWGMVVG mat_peptide: 27..532 product: UDP-glucuronosyltransferase 1-6 isoform 1 calculated_mol_wt: 57896 peptide sequence: DKLLVVPQDGSHWLSMKDIVEVLSDRGHEIVVVVPEVNLLLKESKYYTRKIYPVPYDQEELKNRYQSFGNNHFAERSFLTAPQTEYRNNMIVIGLYFINCQSLLQDRDTLNFFKESKFDALFTDPALPCGVILAEYLGLPSVYLFRGFPCSLEHTFSRSPDPVSYIPRCYTKFSDHMTFSQRVANFLVNLLEPYLFYCLFSKYEELASAVLKRDVDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCKKRKDLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

Gene Information

Entrez Gene ID
54578
Gene Name
UDP glucuronosyltransferase 1 family, polypeptide A6
Gene Symbol
UGT1A6
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:UniProt C endoplasmic reticulum
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0019899 IDA:BHF-UCL F enzyme binding
GO:0015020 IDA:UniProt F glucuronosyltransferase activity
GO:0046982 IDA:UniProt F protein heterodimerization activity
GO:0042803 IDA:UniProt F protein homodimerization activity
GO:0052695 IDA:UniProt P cellular glucuronidation
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0006805 IDA:UniProtKB P xenobiotic metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa05204 Chemical carcinogenesis

Domain Information

InterPro Annotations

Accession Description
IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase

UniProt Annotations

Entry Information

Gene Name
UDP glucuronosyltransferase 1 family, polypeptide A6
Protein Entry
Q5DT01_HUMAN
UniProt ID
Q5DT01
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=i1; IsoId=P19224-1; Sequence=Displayed; Name=2; IsoId=P19224-2; Sequence=VSP_045779; Note=No experimental confirmation available.; Name=3; Synonyms=i2, UGT1A6s; IsoId=P19224-3; Sequence=VSP_053962;
Catalytic Activity UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Function UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 3 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity).
Miscellaneous The gene is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.
Polymorphism Polymorphisms in the UGT1A6 gene define four common haplotypes: UGT1A6*1, UGT1A6*2, UGT1A6*3 and UGT1A6*4. Liver tissue samples that were homozygous for UGT1A6*2 exhibited a high rate of glucuronidation relative to tissues with other genotypes. Biochemical kinetic studies indicate that the UGT1A6*2 allozyme, expressed homozygously, had almost two-fold greater activity toward p-nitrophenol than UGT1A6*1 and when expressed heterozygously (UGT1A6*1/*2) it is associated with low enzyme activity. Common genetic variation in UGT1A6 confers functionally significant differences in biochemical phenotype. This genetic variation might impact clinical efficacy or toxicity of drugs metabolized by UGT1A6.
Sequence Caution Sequence=BM924331; Type=Erroneous termination; Positions=420; Note=Translated as Glu.; Evidence= ; Sequence=BM924331; Type=Frameshift; Positions=451, 463; Evidence= ; Sequence=BM924331; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence= ;
Similarity Belongs to the UDP-glycosyltransferase family.
Subcellular Location Microsome. Endoplasmic reticulum membrane {ECO
Subunit Isoform 1 interacts with isoform 3/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 3. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A7, UGT1A8, UGT1A9 and UGT1A10.
Tissue Specificity Expressed in skin. Isoforms 1 and 3 are expressed in kidney and liver. Isoform 1 but not isoform 2 is expressed in colon, esophagus and small intestine.

Identical and Related Proteins

Unique RefSeq proteins for LMP002941 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
45827765 RefSeq NP_001063 532 UDP-glucuronosyltransferase 1-6 isoform 1 precursor
45827767 RefSeq NP_995584 265 UDP-glucuronosyltransferase 1-6 isoform 2

Identical Sequences to LMP002941 proteins

Reference Database Accession Length Protein Name
GI:45827765 GenBank ADA53240.1 532 Sequence 1070 from patent US 7625699
GI:45827765 GenBank ADT46658.1 532 Sequence 319 from patent US 7842466
GI:45827765 GenBank ADT46659.1 532 Sequence 320 from patent US 7842466
GI:45827767 GenBank ADT46669.1 265 Sequence 330 from patent US 7842466
GI:45827765 GenBank AEN34985.1 532 Sequence 913 from patent US 7998689
GI:45827765 GenBank AEN34986.1 532 Sequence 914 from patent US 7998689
GI:45827765 GenBank AHE01396.1 532 Sequence 56312 from patent US 8586006
GI:45827767 GenBank AHE01397.1 265 Sequence 56313 from patent US 8586006

Related Sequences to LMP002941 proteins

Reference Database Accession Length Protein Name
GI:45827765 GenBank AAH19861.1 532 UDP glucuronosyltransferase 1 family, polypeptide A6 [Homo sapiens]
GI:45827767 GenBank EAW71055.1 532 hCG2039726, isoform CRA_c [Homo sapiens]
GI:45827767 GenBank AEN34985.1 532 Sequence 913 from patent US 7998689
GI:45827767 GenBank AEN34986.1 532 Sequence 914 from patent US 7998689
GI:45827767 GenBank AHE01396.1 532 Sequence 56312 from patent US 8586006
GI:45827765 GenBank AIC56553.1 532 UGT1A6, partial [synthetic construct]
GI:45827767 RefSeq NP_001063.2 532 UDP-glucuronosyltransferase 1-6 isoform 1 precursor [Homo sapiens]
GI:45827765 RefSeq NP_001125641.1 532 UDP-glucuronosyltransferase 1-6 [Pongo abelii]
GI:45827765 RefSeq XP_001151168.2 532 PREDICTED: UDP-glucuronosyltransferase 1-6 isoform X4 [Pan troglodytes]
GI:45827765 RefSeq XP_004033437.1 532 PREDICTED: UDP-glucuronosyltransferase 1-6-like isoform 2 [Gorilla gorilla gorilla]
GI:45827765 RefSeq XP_008963954.1 532 PREDICTED: UDP-glucuronosyltransferase 1-6 isoform X3 [Pan paniscus]
GI:45827767 SwissProt P19224.2 532 RecName: Full=UDP-glucuronosyltransferase 1-6; Short=UDPGT 1-6; Short=UGT1*6; Short=UGT1-06; Short=UGT1.6; AltName: Full=Phenol-metabolizing UDP-glucuronosyltransferase; AltName: Full=UDP-glucuronosyltransferase 1-F; Short=UGT-1F; Short=UGT1F; AltName: Full=UDP-glucuronosyltransferase 1A6; Flags: Precursor [Homo sapiens]