Gene/Proteome Database (LMPD)
LMPD ID
LMP002944
Gene ID
Species
Mus musculus (Mouse)
Gene Name
estrogen related receptor, alpha
Gene Symbol
Synonyms
ERRalpha; Err1; Estrra; Nr3b1
Alternate Names
steroid hormone receptor ERR1; ERR-alpha; estrogen receptor-like 1; estrogen receptor related 1; estrogen-related receptor alpha; nuclear receptor subfamily 3 group B member 1; Steroid hormone receptor ERR1 (Estrogen-related receptor, alpha) (ERR-alpha) (Estrogen receptor-like 1)
Chromosome
19
Map Location
19 A|19 5.08 cM
Proteins
| steroid hormone receptor ERR1 | |
|---|---|
| Refseq ID | NP_031979 |
| Protein GI | 112293262 |
| UniProt ID | O08580 |
| mRNA ID | NM_007953 |
| Length | 422 |
| RefSeq Status | VALIDATED |
| MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVTLASGPAPARCLPGHKEEEDGEGAGSGEQGSGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAPVNALVSHLLVVEPEKLYAMPDPASPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAGLGDLGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLEAMMD | |
Gene Information
Entrez Gene ID
Gene Name
estrogen related receptor, alpha
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0045171 | IEA:Ensembl | C | intercellular bridge |
| GO:0015630 | IEA:Ensembl | C | microtubule cytoskeleton |
| GO:0005730 | IEA:Ensembl | C | nucleolus |
| GO:0005634 | IDA:MGI | C | nucleus |
| GO:0003677 | IDA:MGI | F | DNA binding |
| GO:0000978 | IDA:NTNU_SB | F | RNA polymerase II core promoter proximal region sequence-specific DNA binding |
| GO:0001078 | IDA:NTNU_SB | F | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription |
| GO:0001077 | IDA:NTNU_SB | F | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription |
| GO:0043565 | ISS:UniProtKB | F | sequence-specific DNA binding |
| GO:0003700 | IDA:MGI | F | sequence-specific DNA binding transcription factor activity |
| GO:0005496 | IEA:InterPro | F | steroid binding |
| GO:0003707 | IEA:InterPro | F | steroid hormone receptor activity |
| GO:0008270 | IEA:InterPro | F | zinc ion binding |
| GO:0051216 | IEA:Ensembl | P | cartilage development |
| GO:0000122 | IDA:NTNU_SB | P | negative regulation of transcription from RNA polymerase II promoter |
| GO:0045944 | IDA:NTNU_SB | P | positive regulation of transcription from RNA polymerase II promoter |
| GO:0042127 | IEA:Ensembl | P | regulation of cell proliferation |
| GO:0045667 | IEA:Ensembl | P | regulation of osteoblast differentiation |
| GO:0045670 | IEA:Ensembl | P | regulation of osteoclast differentiation |
| GO:0006355 | ISS:UniProtKB | P | regulation of transcription, DNA-templated |
REACTOME Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR008946 | Nuclear hormone receptor, ligand-binding |
| IPR000536 | Nuclear hormone receptor, ligand-binding, core |
| IPR024178 | Oestrogen receptor/oestrogen-related receptor |
| IPR027289 | Oestrogen-related receptor |
| IPR001723 | Steroid hormone receptor |
| IPR013088 | Zinc finger, NHR/GATA-type |
| IPR001628 | Zinc finger, nuclear hormone receptor-type |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Developmental Stage | Expressed in an organ specific mannER through mid-to late embryonic development with persistent high-level expression in brown adipose tissue and intestinal mucosa. |
| Disruption Phenotype | No visible phenotype; mice are viable, fertile and display no gross anatomical alterations, with the exception of reduced body weight and peripheral fat deposits. Mice are resistant to a high-fat diet-induced obesity. {ECO:0000269|PubMed:14585956}. |
| Function | Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle (By similarity). {ECO:0000250}. |
| Induction | Activated by diethylstilbestrol (DES) and estradiol in the uterus. |
| Ptm | Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity. {ECO:0000250}. |
| Ptm | Reversibly acetylated. Acetylation by PCAF/KAT2 at Lys-129, Lys-138, Lys-160 and Lys-162 and PCAF/KAT2 decreases transcriptional activity probably by inhibiting DNA-binding activity; deacetylation involves SIRT1 and HDAC8 and increases DNA-binding (By similarity). {ECO:0000250}. |
| Ptm | Sumoylated with SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activity, but has no effect on subcellular location nor on DNA binding (By similarity). {ECO:0000250}. |
| Similarity | Belongs to the nuclear hormone receptor family. NR3 subfamily. {ECO:0000305}. |
| Similarity | Contains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}. |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}. |
| Subunit | Binds DNA as a monomer or a homodimer. Interacts (via the AF2 domain) with coactivator PPARGC1A (via the L3 motif); the interaction greatly enhances transriptional activity of genes involved in energy metabolism. Interacts with PIAS4; the interaction enhances sumoylation (By similarity). {ECO:0000250}. |
| Tissue Specificity | Most highly expressed in kidney, heart, and brown adipocytes. Also found in utERus, cervix and vagina. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002944 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 112293262 | RefSeq | NP_031979 | 422 | steroid hormone receptor ERR1 |
Identical Sequences to LMP002944 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:112293262 | GenBank | EDM12625.1 | 422 | rCG47936 [Rattus norvegicus] |
| GI:112293262 | GenBank | AAI38587.1 | 422 | Estrogen related receptor, alpha [Mus musculus] |
| GI:112293262 | GenBank | AAI71958.1 | 422 | Estrogen related receptor, alpha [Mus musculus] |
| GI:112293262 | RefSeq | NP_001008511.2 | 422 | steroid hormone receptor ERR1 [Rattus norvegicus] |
| GI:112293262 | SwissProt | Q5QJV7.2 | 422 | RecName: Full=Steroid hormone receptor ERR1; AltName: Full=Estrogen-related receptor alpha; Short=ERR-alpha; AltName: Full=Nuclear receptor subfamily 3 group B member 1 [Rattus norvegicus] |
| GI:112293262 | SwissProt | O08580.4 | 422 | RecName: Full=Steroid hormone receptor ERR1; AltName: Full=Estrogen receptor-like 1; AltName: Full=Estrogen-related receptor alpha; Short=ERR-alpha; AltName: Full=Nuclear receptor subfamily 3 group B member 1 [Mus musculus] |
Related Sequences to LMP002944 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:112293262 | GenBank | AAI04702.1 | 461 | Esrra protein, partial [Rattus norvegicus] |
| GI:112293262 | GenBank | EDL33260.1 | 431 | estrogen related receptor, alpha, partial [Mus musculus] |
| GI:112293262 | RefSeq | XP_006230817.1 | 499 | PREDICTED: steroid hormone receptor ERR1 isoform X1 [Rattus norvegicus] |
| GI:112293262 | RefSeq | XP_006527173.1 | 499 | PREDICTED: steroid hormone receptor ERR1 isoform X1 [Mus musculus] |
| GI:112293262 | RefSeq | XP_007650005.1 | 422 | PREDICTED: steroid hormone receptor ERR1 isoform X1 [Cricetulus griseus] |
| GI:112293262 | RefSeq | XP_007608815.1 | 422 | PREDICTED: steroid hormone receptor ERR1 isoform X1 [Cricetulus griseus] |