Gene/Proteome Database (LMPD)

LMPD ID
LMP002949
Gene ID
18709
Species
Mus musculus (Mouse)
Gene Name
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)
Gene Symbol
Pik3r2
Synonyms
p85beta
Alternate Names
phosphatidylinositol 3-kinase regulatory subunit beta; PI3-kinase subunit p85-beta; PI3K regulatory subunit beta; PI3-kinase regulatory subunit beta; ptdIns-3-kinase regulatory subunit beta; ptdIns-3-kinase regulatory subunit p85-beta; phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta
Chromosome
8
Map Location
8 B3.3|8 34.15 cM

Proteins

phosphatidylinositol 3-kinase regulatory subunit beta
Refseq ID NP_032867
Protein GI 244792921
UniProt ID O08908
mRNA ID NM_008841
Length 722
RefSeq Status VALIDATED
MAGAEGFQYRAVYPFRRERPEDLELLPGDLLVVSRVALQALGVADGGERCPHNVGWMPGFNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPLDGSSESGHILPDLAEQFSPPDPAPPILVKLVEAIEQAELDSECYSKPELPATRTDWSLSDLEQWDRTALYDAVKGFLLALPAAVVTPEAAAEAYRALREVAGPVGLVLEPPTLPLHQALTLRFLLQHLGRVARRAPSPDTAVHALASAFGPLLLRIPPSGGEGDGSEPVPDFPVLLLERLVQEHVEEQDAAPPALPPKPSKAKPAPTALANGGSPPSLQDAEWYWGDISREEVNERLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVELISHYRHESLAQYNAKLDTRLLYPVSKYQQDQVVKEDSIEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQDLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQRKINEWLGIKNETEDQYSLMEDEDALPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPSAAR

Gene Information

Entrez Gene ID
18709
Gene Name
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)
Gene Symbol
Pik3r2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005942 NAS:UniProtKB C phosphatidylinositol 3-kinase complex
GO:0035014 IEA:InterPro F phosphatidylinositol 3-kinase regulator activity
GO:0008286 NAS:UniProtKB P insulin receptor signaling pathway
GO:0036092 IMP:GOC P phosphatidylinositol-3-phosphate biosynthetic process
GO:0042325 NAS:UniProtKB P regulation of phosphorylation

KEGG Pathway Links

KEGG Pathway ID Description
mmu04152 AMPK signaling pathway
mmu04550 Signaling pathways regulating pluripotency of stem cells
mmu04024 cAMP signaling pathway
mmu04022 cGMP-PKG signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR001720 PI3 kinase, P85 regulatory subunit
IPR008936 Rho GTPase activation protein
IPR000198 Rho GTPase-activating protein domain
IPR000980 SH2 domain
IPR001452 SH3_domain

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)
Protein Entry
P85B_MOUSE
UniProt ID
O08908
Species
Mouse

Comments

Comment Type Description
Domain The SH2 2 domain is required for interaction with FBXL2 and PTPN13. {ECO:0000250|UniProtKB:O00459}.
Function Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5- trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy. {ECO:0000250|UniProtKB:O00459}.
Interaction O88665:Brd7; NbExp=4; IntAct=EBI-643570, EBI-643930; Q9JK42:Pdk2; NbExp=3; IntAct=EBI-643570, EBI-643530;
Ptm Phosphorylated in response to signaling from activated receptor-type protein kinases. Dephosphorylated by PTPRJ. Dephosphorylated at Tyr-649 by PTPN13. Phosphorylation of Tyr-649 impairs while its dephosphorylation promotes interaction with FBXL2 and SCF(FBXL2)-mediated polyubiquitination. {ECO:0000250|UniProtKB:O00459}.
Ptm Ubiquitinated. Polyubiquitination by the SCF(FBXL2) complex probably promotes proteasomal degradation of PIK3R2. {ECO:0000250|UniProtKB:O00459}.
Similarity Belongs to the PI3K p85 subunit family. {ECO:0000305}.
Similarity Contains 1 Rho-GAP domain. {ECO:0000255|PROSITE- ProRule:PRU00172}.
Similarity Contains 1 SH3 domain. {ECO:0000255|PROSITE- ProRule:PRU00192}.
Similarity Contains 2 SH2 domains. {ECO:0000255|PROSITE- ProRule:PRU00191}.
Subunit Heterodimer of a regulatory subunit PIK3R2 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL. Interacts with FLT1 (tyrosine-phosphorylated) and FLT4 (tyrosine- phosphorylated) (By similarity). Interacts with NYAP1, NYAP2 and MYO16 (PubMed:21946561). Interacts with FBXL2; PIK3R2 is a substrate of the SCF(FBXL2) complex. Interacts with PTPN13; dephosphorylates PIK3R2 (By similarity). {ECO:0000250|UniProtKB:O00459, ECO:0000269|PubMed:21946561}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002949 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
244792921 RefSeq NP_032867 722 phosphatidylinositol 3-kinase regulatory subunit beta

Identical Sequences to LMP002949 proteins

Reference Database Accession Length Protein Name
GI:244792921 GenBank AAH85501.1 722 Phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta) [Mus musculus]
GI:244792921 GenBank EDL28873.1 722 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta) [Mus musculus]
GI:244792921 SwissProt O08908.2 722 RecName: Full=Phosphatidylinositol 3-kinase regulatory subunit beta; Short=PI3-kinase regulatory subunit beta; Short=PI3K regulatory subunit beta; Short=PtdIns-3-kinase regulatory subunit beta; AltName: Full=Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; Short=PI3-kinase subunit p85-beta; Short=PtdIns-3-kinase regulatory subunit p85-beta [Mus musculus]

Related Sequences to LMP002949 proteins

Reference Database Accession Length Protein Name
GI:244792921 DBBJ BAE26969.1 722 unnamed protein product [Mus musculus]
GI:244792921 EMBL CAA73903.1 722 phosphatidylinositol 3-kinase p85 beta subunit [Mus musculus]
GI:244792921 GenBank AAH06796.1 722 Phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta) [Mus musculus]
GI:244792921 GenBank AAH89805.1 722 Phosphoinositide-3-kinase, regulatory subunit 2 (beta) [Rattus norvegicus]
GI:244792921 GenBank ABK42317.1 722 PI3K-p85beta [synthetic construct]
GI:244792921 RefSeq NP_071521.2 722 phosphatidylinositol 3-kinase regulatory subunit beta [Rattus norvegicus]