Gene/Proteome Database (LMPD)
Proteins
| nuclear receptor subfamily 5 group A member 2 isoform 1 | |
|---|---|
| Refseq ID | NP_995582 |
| Protein GI | 45545405 |
| UniProt ID | O00482 |
| mRNA ID | NM_205860 |
| Length | 541 |
| RefSeq Status | VALIDATED |
| MSSNSDTGDLQESLKHGLTPIGAGLPDRHGSPIPARGRLVMLPKVETEALGLARSHGEQGQMPENMQVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQNCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTISSAIQNIHSASKGLPLNHAALPPTDYDRSPFVTSPISMTMPPHGSLQGYQTYGHFPSRAIKSEYPDPYTSSPESIMGYSYMDSYQTSSPASIPHLILELLKCEPDEPQVQAKIMAYLQQEQANRSKHEKLSTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHAKRA | |
| nuclear receptor subfamily 5 group A member 2 isoform 2 | |
|---|---|
| Refseq ID | NP_003813 |
| Protein GI | 4504343 |
| UniProt ID | O00482 |
| mRNA ID | NM_003822 |
| Length | 495 |
| RefSeq Status | VALIDATED |
| MSSNSDTGDLQESLKHGLTPIVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQNCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTISSAIQNIHSASKGLPLNHAALPPTDYDRSPFVTSPISMTMPPHGSLQGYQTYGHFPSRAIKSEYPDPYTSSPESIMGYSYMDSYQTSSPASIPHLILELLKCEPDEPQVQAKIMAYLQQEQANRSKHEKLSTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHAKRA | |
| nuclear receptor subfamily 5 group A member 2 isoform 3 | |
|---|---|
| Refseq ID | NP_001263393 |
| Protein GI | 451172094 |
| UniProt ID | O00482 |
| mRNA ID | NM_001276464 |
| Length | 469 |
| RefSeq Status | VALIDATED |
| MVNYSYDEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQNCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTISSAIQNIHSASKGLPLNHAALPPTDYDRSPFVTSPISMTMPPHGSLQGYQTYGHFPSRAIKSEYPDPYTSSPESIMGYSYMDSYQTSSPASIPHLILELLKCEPDEPQVQAKIMAYLQQEQANRSKHEKLSTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHAKRA | |
Gene Information
Entrez Gene ID
Gene Name
nuclear receptor subfamily 5, group A, member 2
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | IDA:BHF-UCL | C | cytoplasm |
| GO:0005654 | TAS:Reactome | C | nucleoplasm |
| GO:0005634 | IDA:BHF-UCL | C | nucleus |
| GO:0003677 | IDA:UniProtKB | F | DNA binding |
| GO:0004879 | TAS:UniProtKB | F | ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity |
| GO:0005543 | IDA:UniProtKB | F | phospholipid binding |
| GO:0000978 | IEA:Ensembl | F | RNA polymerase II core promoter proximal region sequence-specific DNA binding |
| GO:0001077 | IEA:Ensembl | F | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription |
| GO:0003705 | TAS:ProtInc | F | RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity |
| GO:0043565 | IDA:UniProtKB | F | sequence-specific DNA binding |
| GO:0003700 | IDA:UniProtKB | F | sequence-specific DNA binding transcription factor activity |
| GO:0003707 | IEA:InterPro | F | steroid hormone receptor activity |
| GO:0044212 | IDA:BHF-UCL | F | transcription regulatory region DNA binding |
| GO:0008270 | IEA:InterPro | F | zinc ion binding |
| GO:0008206 | IEA:Ensembl | P | bile acid metabolic process |
| GO:0042632 | IEA:Ensembl | P | cholesterol homeostasis |
| GO:0009790 | TAS:UniProtKB | P | embryo development |
| GO:0031018 | TAS:Reactome | P | endocrine pancreas development |
| GO:0010467 | TAS:Reactome | P | gene expression |
| GO:0042592 | NAS:UniProtKB | P | homeostatic process |
| GO:0030522 | TAS:GOC | P | intracellular receptor signaling pathway |
| GO:0045893 | IDA:BHF-UCL | P | positive regulation of transcription, DNA-templated |
| GO:0045070 | IDA:BHF-UCL | P | positive regulation of viral genome replication |
| GO:0042127 | IEA:Ensembl | P | regulation of cell proliferation |
| GO:0006355 | IDA:UniProtKB | P | regulation of transcription, DNA-templated |
| GO:0006367 | TAS:Reactome | P | transcription initiation from RNA polymerase II promoter |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa04950 | Maturity onset diabetes of the young |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_13698 | Regulation of beta-cell development |
| REACT_13778 | Regulation of gene expression in early pancreatic precursor cells |
Domain Information
InterPro Annotations
UniProt Annotations
Entry Information
Gene Name
nuclear receptor subfamily 5, group A, member 2
Protein Entry
NR5A2_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=4; Name=2; Synonyms=B1F2; IsoId=O00482-1; Sequence=Displayed; Name=1; IsoId=O00482-2; Sequence=VSP_003716; Name=3; IsoId=O00482-3; Sequence=VSP_003717; Note=Does not induce CYP7A promoter activity.; Name=4; IsoId=O00482-4; Sequence=VSP_054548; Note=No experimental confirmation available.; |
| Function | Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. |
| Interaction | O60869:EDF1; NbExp=2; IntAct=EBI-781320, EBI-781301; Q92786:PROX1; NbExp=9; IntAct=EBI-9257474, EBI-3912635; |
| Similarity | Belongs to the nuclear hormone receptor family. NR5 subfamily. |
| Similarity | Contains 1 nuclear receptor DNA-binding domain. |
| Subcellular Location | Nucleus . |
| Subunit | Binds DNA as a monomer (By similarity). Interacts with GRIP1, NCOA2 and NR0B2. {ECO |
| Tissue Specificity | Abundantly expressed in pancreas, less in liver, very low levels in heart and lung. Expressed in the Hep-G2 cell line. Isoform 1 and isoform 2 seem to be present in fetal and adult liver and Hep-G2 cells. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002951 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 45545405 | RefSeq | NP_995582 | 541 | nuclear receptor subfamily 5 group A member 2 isoform 1 |
| 4504343 | RefSeq | NP_003813 | 495 | nuclear receptor subfamily 5 group A member 2 isoform 2 |
| 451172094 | RefSeq | NP_001263393 | 469 | nuclear receptor subfamily 5 group A member 2 isoform 3 |
Identical Sequences to LMP002951 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:45545405 | GenBank | AAE82738.1 | 541 | Sequence 6 from patent US 6297019 |
| GI:45545405 | GenBank | EAW91308.1 | 541 | nuclear receptor subfamily 5, group A, member 2, isoform CRA_d [Homo sapiens] |
| GI:4504343 | GenBank | AHD75911.1 | 495 | Sequence 18294 from patent US 8586006 |
| GI:45545405 | GenBank | AHD75912.1 | 541 | Sequence 18295 from patent US 8586006 |
| GI:4504343 | GenBank | AIC48789.1 | 495 | NR5A2, partial [synthetic construct] |
| GI:45545405 | RefSeq | XP_001142695.1 | 541 | PREDICTED: nuclear receptor subfamily 5 group A member 2 isoform X1 [Pan troglodytes] |
| GI:45545405 | RefSeq | XP_003823109.1 | 541 | PREDICTED: nuclear receptor subfamily 5 group A member 2 isoform X3 [Pan paniscus] |
| GI:4504343 | RefSeq | XP_003823110.1 | 495 | PREDICTED: nuclear receptor subfamily 5 group A member 2 isoform X1 [Pan paniscus] |
| GI:4504343 | RefSeq | XP_003893394.1 | 495 | PREDICTED: nuclear receptor subfamily 5 group A member 2 isoform X4 [Papio anubis] |
| GI:45545405 | RefSeq | XP_004028157.1 | 541 | PREDICTED: nuclear receptor subfamily 5 group A member 2 isoform 1 [Gorilla gorilla gorilla] |
| GI:4504343 | RefSeq | XP_004028158.1 | 495 | PREDICTED: nuclear receptor subfamily 5 group A member 2 isoform 2 [Gorilla gorilla gorilla] |
| GI:4504343 | RefSeq | XP_005540393.1 | 495 | PREDICTED: nuclear receptor subfamily 5 group A member 2-like isoform X2 [Macaca fascicularis] |
| GI:451172094 | RefSeq | XP_009188904.1 | 469 | PREDICTED: nuclear receptor subfamily 5 group A member 2 isoform X5 [Papio anubis] |
| GI:451172094 | RefSeq | XP_009188920.1 | 469 | PREDICTED: nuclear receptor subfamily 5 group A member 2 isoform X5 [Papio anubis] |
| GI:451172094 | RefSeq | XP_009438685.1 | 469 | PREDICTED: nuclear receptor subfamily 5 group A member 2 isoform X5 [Pan troglodytes] |
| GI:451172094 | RefSeq | XP_009438689.1 | 469 | PREDICTED: nuclear receptor subfamily 5 group A member 2 isoform X5 [Pan troglodytes] |
| GI:451172094 | RefSeq | XP_009438693.1 | 469 | PREDICTED: nuclear receptor subfamily 5 group A member 2 isoform X5 [Pan troglodytes] |
| GI:451172094 | RefSeq | XP_009438697.1 | 469 | PREDICTED: nuclear receptor subfamily 5 group A member 2 isoform X5 [Pan troglodytes] |
Related Sequences to LMP002951 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:45545405 | DBBJ | BAA34092.1 | 541 | FTZ-F1 related protein [Homo sapiens] |
| GI:451172094 | GenBank | AAD26565.1 | 541 | hepatocytic transcription factor hB1F-2 [Homo sapiens] |
| GI:451172094 | GenBank | EAW91308.1 | 541 | nuclear receptor subfamily 5, group A, member 2, isoform CRA_d [Homo sapiens] |
| GI:4504343 | GenBank | ACM81569.1 | 505 | Sequence 7067 from patent US 6812339 |
| GI:451172094 | RefSeq | NP_995582.1 | 541 | nuclear receptor subfamily 5 group A member 2 isoform 1 [Homo sapiens] |
| GI:45545405 | RefSeq | XP_001110281.1 | 541 | PREDICTED: nuclear receptor subfamily 5 group A member 2-like isoform 3 [Macaca mulatta] |
| GI:4504343 | RefSeq | XP_001110202.1 | 495 | PREDICTED: nuclear receptor subfamily 5 group A member 2-like isoform 2 [Macaca mulatta] |
| GI:451172094 | RefSeq | XP_001142695.1 | 541 | PREDICTED: nuclear receptor subfamily 5 group A member 2 isoform X1 [Pan troglodytes] |
| GI:4504343 | RefSeq | XP_002760663.1 | 495 | PREDICTED: nuclear receptor subfamily 5 group A member 2 isoform X2 [Callithrix jacchus] |
| GI:45545405 | RefSeq | XP_003264567.1 | 541 | PREDICTED: LOW QUALITY PROTEIN: nuclear receptor subfamily 5 group A member 2 [Nomascus leucogenys] |
| GI:4504343 | RefSeq | XP_003792352.1 | 495 | PREDICTED: nuclear receptor subfamily 5 group A member 2 isoform 2 [Otolemur garnettii] |
| GI:45545405 | RefSeq | XP_003893393.1 | 541 | PREDICTED: nuclear receptor subfamily 5 group A member 2 isoform X1 [Papio anubis] |
| GI:4504343 | RefSeq | XP_003938293.1 | 495 | PREDICTED: nuclear receptor subfamily 5 group A member 2 isoform X2 [Saimiri boliviensis boliviensis] |
| GI:451172094 | RefSeq | XP_004028157.1 | 541 | PREDICTED: nuclear receptor subfamily 5 group A member 2 isoform 1 [Gorilla gorilla gorilla] |
| GI:4504343 | RefSeq | XP_004439034.1 | 495 | PREDICTED: nuclear receptor subfamily 5 group A member 2 isoform 2 [Ceratotherium simum simum] |
| GI:45545405 | RefSeq | XP_005540392.1 | 541 | PREDICTED: nuclear receptor subfamily 5 group A member 2-like isoform X1 [Macaca fascicularis] |
| GI:45545405 | RefSeq | XP_007987223.1 | 541 | PREDICTED: nuclear receptor subfamily 5 group A member 2 isoform X1 [Chlorocebus sabaeus] |
| GI:451172094 | SwissProt | O00482.2 | 541 | RecName: Full=Nuclear receptor subfamily 5 group A member 2; AltName: Full=Alpha-1-fetoprotein transcription factor; AltName: Full=B1-binding factor; Short=hB1F; AltName: Full=CYP7A promoter-binding factor; AltName: Full=Hepatocytic transcription factor; AltName: Full=Liver receptor homolog 1; Short=LRH-1 [Homo sapiens] |