Gene/Proteome Database (LMPD)

LMPD ID
LMP002953
Gene ID
19211
Species
Mus musculus (Mouse)
Gene Name
phosphatase and tensin homolog
Gene Symbol
Pten
Synonyms
2310035O07Rik; A130070J02Rik; AI463227; B430203M17Rik; MMAC1; TEP1
Alternate Names
phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; mitochondrial PTENalpha; mutated in multiple advanced cancers 1; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Chromosome
19
Map Location
19 C1|19 28.14 cM
EC Number
3.1.3.16

Proteins

phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Refseq ID NP_032986
Protein GI 6679523
UniProt ID O08586
mRNA ID NM_008960
Length 403
RefSeq Status VALIDATED
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHSQITKV

Gene Information

Entrez Gene ID
19211
Gene Name
phosphatase and tensin homolog
Gene Symbol
Pten
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0043220 IDA:BHF-UCL C Schmidt-Lanterman incisure
GO:0005737 ISS:UniProtKB C cytoplasm
GO:0009898 IEA:Ensembl C cytoplasmic side of plasma membrane
GO:0043197 IEA:Ensembl C dendritic spine
GO:0005739 IEA:Ensembl C mitochondrion
GO:0035749 IDA:BHF-UCL C myelin sheath adaxonal region
GO:0043005 IDA:BHF-UCL C neuron projection
GO:0005634 IDA:MGI C nucleus
GO:0045211 IEA:Ensembl C postsynaptic membrane
GO:0030165 ISS:UniProtKB F PDZ domain binding
GO:0051717 ISS:UniProtKB F inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
GO:0000287 IEA:InterPro F magnesium ion binding
GO:0016314 ISS:UniProtKB F phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0051800 ISS:UniProtKB F phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
GO:0004438 ISS:UniProtKB F phosphatidylinositol-3-phosphatase activity
GO:0019901 IPI:UniProtKB F protein kinase binding
GO:0004722 ISS:UniProtKB F protein serine/threonine phosphatase activity
GO:0004725 ISS:UniProtKB F protein tyrosine phosphatase activity
GO:0008138 IEA:InterPro F protein tyrosine/serine/threonine phosphatase activity
GO:0007092 IMP:BHF-UCL P activation of mitotic anaphase-promoting complex activity
GO:0007568 IEA:Ensembl P aging
GO:0001525 IMP:MGI P angiogenesis
GO:0006915 IEA:UniProtKB-KW P apoptotic process
GO:0048854 IMP:BHF-UCL P brain morphogenesis
GO:0060070 IEA:Ensembl P canonical Wnt signaling pathway
GO:0048738 IMP:MGI P cardiac muscle tissue development
GO:0016477 IMP:MGI P cell migration
GO:0007417 IMP:MGI P central nervous system development
GO:0032286 IMP:BHF-UCL P central nervous system myelin maintenance
GO:0021955 IMP:BHF-UCL P central nervous system neuron axonogenesis
GO:0060997 IMP:BHF-UCL P dendritic spine morphogenesis
GO:0021542 IMP:BHF-UCL P dentate gyrus development
GO:0043542 IMP:MGI P endothelial cell migration
GO:0048853 IMP:BHF-UCL P forebrain morphogenesis
GO:0007507 IMP:MGI P heart development
GO:0046855 ISS:UniProtKB P inositol phosphate dephosphorylation
GO:0007611 IMP:BHF-UCL P learning or memory
GO:0045475 IMP:BHF-UCL P locomotor rhythm
GO:0007626 IMP:BHF-UCL P locomotory behavior
GO:0060292 IEA:Ensembl P long term synaptic depression
GO:0060291 IMP:BHF-UCL P long-term synaptic potentiation
GO:0060179 IMP:BHF-UCL P male mating behavior
GO:0042711 IMP:BHF-UCL P maternal behavior
GO:0007613 IEA:Ensembl P memory
GO:0033555 IMP:BHF-UCL P multicellular organismal response to stress
GO:2000134 IEA:Ensembl P negative regulation of G1/S transition of mitotic cell cycle
GO:0043066 IMP:UniProtKB P negative regulation of apoptotic process
GO:0050771 IMP:BHF-UCL P negative regulation of axonogenesis
GO:0090344 IMP:BHF-UCL P negative regulation of cell aging
GO:0030336 ISS:UniProtKB P negative regulation of cell migration
GO:0008285 ISS:UniProtKB P negative regulation of cell proliferation
GO:0045792 IMP:BHF-UCL P negative regulation of cell size
GO:0031658 IEA:Ensembl P negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0061002 IMP:BHF-UCL P negative regulation of dendritic spine morphogenesis
GO:0050680 IMP:MGI P negative regulation of epithelial cell proliferation
GO:0090394 IMP:BHF-UCL P negative regulation of excitatory postsynaptic membrane potential
GO:0051895 ISS:UniProtKB P negative regulation of focal adhesion assembly
GO:0031642 IMP:MGI P negative regulation of myelination
GO:0046621 IMP:BHF-UCL P negative regulation of organ growth
GO:0050765 IEA:Ensembl P negative regulation of phagocytosis
GO:0051898 IMP:UniProtKB P negative regulation of protein kinase B signaling
GO:0090071 IMP:BHF-UCL P negative regulation of ribosome biogenesis
GO:2000808 IMP:BHF-UCL P negative regulation of synaptic vesicle clustering
GO:0007270 IMP:BHF-UCL P neuron-neuron synaptic transmission
GO:0035335 ISS:GOC P peptidyl-tyrosine dephosphorylation
GO:0046856 ISS:UniProtKB P phosphatidylinositol dephosphorylation
GO:0048008 IEA:Ensembl P platelet-derived growth factor receptor signaling pathway
GO:0043065 IEA:Ensembl P positive regulation of apoptotic process
GO:2001235 IMP:MGI P positive regulation of apoptotic signaling pathway
GO:0008284 IMP:BHF-UCL P positive regulation of cell proliferation
GO:2000463 IMP:BHF-UCL P positive regulation of excitatory postsynaptic membrane potential
GO:2000060 IEA:Ensembl P positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051091 IEA:Ensembl P positive regulation of sequence-specific DNA binding transcription factor activity
GO:0097107 IMP:BHF-UCL P postsynaptic density assembly
GO:0060134 IMP:BHF-UCL P prepulse inhibition
GO:0097105 IMP:BHF-UCL P presynaptic membrane assembly
GO:0060736 IMP:MGI P prostate gland growth
GO:0006470 ISS:UniProtKB P protein dephosphorylation
GO:0043491 IMP:UniProtKB P protein kinase B signaling
GO:0050821 IEA:Ensembl P protein stabilization
GO:0002902 IMP:MGI P regulation of B cell apoptotic process
GO:0051726 IGI:MGI P regulation of cell cycle
GO:0032535 IMP:BHF-UCL P regulation of cellular component size
GO:0033032 IMP:MGI P regulation of myeloid cell apoptotic process
GO:0010975 IMP:UniProtKB P regulation of neuron projection development
GO:0031647 ISS:UniProtKB P regulation of protein stability
GO:0033198 IEA:Ensembl P response to ATP
GO:0046685 IEA:Ensembl P response to arsenic-containing substance
GO:0042493 IEA:Ensembl P response to drug
GO:0032355 IEA:Ensembl P response to estradiol
GO:0045471 IEA:Ensembl P response to ethanol
GO:0009749 IEA:Ensembl P response to glucose
GO:0007584 IEA:Ensembl P response to nutrient
GO:0010043 IEA:Ensembl P response to zinc ion
GO:0060024 IMP:BHF-UCL P rhythmic synaptic transmission
GO:0035176 IMP:BHF-UCL P social behavior
GO:0007416 IMP:BHF-UCL P synapse assembly
GO:0060074 IMP:BHF-UCL P synapse maturation

KEGG Pathway Links

KEGG Pathway ID Description
mmu04068 FoxO signaling pathway
mmu05161 Hepatitis B
mmu05206 MicroRNAs in cancer
mmu04151 PI3K-Akt signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR017361 Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN
IPR000008 C2 domain
IPR000340 Dual specificity phosphatase, catalytic domain
IPR016130 Protein-tyrosine phosphatase, active site
IPR029021 Protein-tyrosine phosphatase-like
IPR014020 Tensin phosphatase, C2 domain
IPR029023 Tensin phosphatase, lipid phosphatase domain

UniProt Annotations

Entry Information

Gene Name
phosphatase and tensin homolog
Protein Entry
PTEN_MOUSE
UniProt ID
O08586
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Phosphatidylinositol 3,4,5-trisphosphate + H(2)O = phosphatidylinositol 4,5-bisphosphate + phosphate.
Catalytic Activity Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
Catalytic Activity [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Function In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement (By similarity). Tumor suppressor. Acts as a dual- specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3- phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K- AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. {ECO:0000250, ECO:0000269|PubMed:10339565, ECO:0000269|PubMed:19778506}.
Interaction P49452:Cenpc; NbExp=2; IntAct=EBI-1186266, EBI-1186252; Q9JHL1:Slc9a3r2; NbExp=3; IntAct=EBI-1186266, EBI-538451; P02340:Tp53; NbExp=4; IntAct=EBI-1186266, EBI-474016;
Ptm Constitutively phosphorylated by CK2 under normal conditions. Phosphorylation results in an inhibited activity towards PIP3. Phosphorylation can both inhibit or promote PDZ-binding. Phosphorylation at Tyr-336 by FRK/PTK5 protects this protein from ubiquitin-mediated degradation probably by inhibiting its binding to NEDD4 (By similarity). Phosphorylation by PLK3 promotes its stability and prevents its degradation by the proteasome. Phosphorylation by ROCK1 is essential for its stability and activity. {ECO:0000250, ECO:0000269|PubMed:17242355, ECO:0000269|PubMed:19473982, ECO:0000269|PubMed:20008297, ECO:0000269|PubMed:20940307}.
Ptm Monoubiquitinated; monoubiquitination is increased in presence of retinoic acid. Deubiquitinated by USP7; leading to its nuclear exclusion. Monoubiquitination of one of either Lys-13 and Lys-289 amino acid is sufficient to modulate PTEN compartmentalization (By similarity). Ubiquitinated by XIAP/BIRC4. {ECO:0000250, ECO:0000269|PubMed:19473982}.
Similarity Contains 1 C2 tensin-type domain. {ECO:0000255|PROSITE-ProRule:PRU00589}.
Similarity Contains 1 phosphatase tensin-type domain. {ECO:0000255|PROSITE-ProRule:PRU00590}.
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Note=Monoubiquitinated form is nuclear (By similarity). Nonubiquitinated form is cytoplasmic. Colocalized with PML and USP7 in PML nuclear bodies. XIAP/BIRC4 promotes its nuclear localization. {ECO:0000250, ECO:0000269|PubMed:19473982}.
Subunit Monomer. The unphosphorylated form interacts with the second PDZ domain of AIP1. Interacts with MAGI2, MAGI3, MAST1 and MAST3, but neither with MAST4 nor with DLG5; interaction with MAGI2 increases protein stability (By similarity). Interacts with NEDD4. Interacts with NDFIP1 and NDFIP2; in the presence of NEDD4 or ITCH, this interaction promotes PTEN ubiquitination (By similarity). Interacts (via C2 domain) with FRK (By similarity). Interacts with USP7; the interaction is direct (By similarity). Interacts with ROCK1. Interacts with XIAP/BIRC4. Interacts with STK11; the interaction phosphorylates PTEN (By similarity). {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002953 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6679523 RefSeq NP_032986 403 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Identical Sequences to LMP002953 proteins

Reference Database Accession Length Protein Name
GI:6679523 GenBank ADR92404.1 403 Sequence 2 from patent US 7745485
GI:6679523 GenBank AFL00281.1 403 Sequence 2 from patent US 8163691
GI:6679523 RefSeq XP_003510358.1 403 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [Cricetulus griseus]
GI:6679523 RefSeq XP_005063745.1 403 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [Mesocricetus auratus]
GI:6679523 RefSeq XP_006996261.1 403 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [Peromyscus maniculatus bairdii]
GI:6679523 RefSeq XP_007632109.1 403 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [Cricetulus griseus]

Related Sequences to LMP002953 proteins

Reference Database Accession Length Protein Name
GI:6679523 GenBank AAN99407.1 559 Sequence 15 from patent US 6482795
GI:6679523 GenBank ABL22617.1 559 Sequence 15 from patent US 7129040
GI:6679523 GenBank ABT04307.1 559 Sequence 15 from patent US 7217795
GI:6679523 GenBank ADM06307.1 559 Sequence 15 from patent US 7732576
GI:6679523 GenBank ERE79056.1 410 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [Cricetulus griseus]
GI:6679523 Third Party Genbank DAA64595.1 572 TPA_exp: mitochondrial PTENalpha [Mus musculus]