Gene/Proteome Database (LMPD)

LMPD ID
LMP002954
Gene ID
235293
Species
Mus musculus (Mouse)
Gene Name
sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae)
Gene Symbol
Sc5d
Synonyms
A830037K02; A830073K23Rik; Sc5dl
Alternate Names
lathosterol oxidase; C-5 sterol desaturase; lathosterol 5-desaturase; delta(7)-sterol 5-desaturase
Chromosome
9
Map Location
9|9 B
EC Number
1.14.21.6

Proteins

lathosterol oxidase
Refseq ID NP_766357
Protein GI 27777693
UniProt ID O88822
mRNA ID NM_172769
Length 299
RefSeq Status VALIDATED
MDLVLSAADYYFFTPYVYPATWPEDNIIRQTISLLIVTNLGAYILYFFCATLSYYFVYDHSLMKHPQFLKNQVSREIVFTVKSLPWISIPTVSLFLLELRGYSKLYDDIGDFPNGWIHLMVSVVSFLFFTDMLIYWIHRGLHHRLVYKRIHKPHHIWKIPTPFASHAFHPVDGFLQSLPYHIYPFVFPLHKVVYLGLYVLVNVWTISIHDGDFRVPQILRPFINGSAHHTDHHMFFDYNYGQYFTLWDRIGGSFKHPSSFEGKGPHSYVKNMTEKESNSFAENGCKGKKVGNGEFTKNK

Gene Information

Entrez Gene ID
235293
Gene Name
sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae)
Gene Symbol
Sc5d
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0000248 IEA:Ensembl F C-5 sterol desaturase activity
GO:0005506 IEA:InterPro F iron ion binding
GO:0050046 IEA:UniProtKB-EC F lathosterol oxidase activity
GO:0033490 IEA:Ensembl P cholesterol biosynthetic process via lathosterol
GO:0006633 IEA:InterPro P fatty acid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00100 Steroid biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5894006 Activation of gene expression by SREBF (SREBP)

Domain Information

InterPro Annotations

Accession Description
IPR006694 Fatty_acid_hydroxylase

UniProt Annotations

Entry Information

Gene Name
sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae)
Protein Entry
SC5D_MOUSE
UniProt ID
O88822
Species
Mouse

Comments

Comment Type Description
Catalytic Activity 5-alpha-cholest-7-en-3-beta-ol + NAD(P)H + O(2) = cholesta-5,7-dien-3-beta-ol + NAD(P)(+) + 2 H(2)O.
Cofactor Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000250};
Domain The histidine box domains may contain the active site and/or be involved in metal ion binding.
Function Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol.
Similarity Belongs to the sterol desaturase family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP002954 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
27777693 RefSeq NP_766357 299 lathosterol oxidase

Identical Sequences to LMP002954 proteins

Reference Database Accession Length Protein Name
GI:27777693 DBBJ BAC31666.1 299 unnamed protein product [Mus musculus]
GI:27777693 DBBJ BAC36944.1 299 unnamed protein product [Mus musculus]
GI:27777693 RefSeq XP_006510316.1 299 PREDICTED: lathosterol oxidase isoform X1 [Mus musculus]
GI:27777693 SwissProt O88822.2 299 RecName: Full=Lathosterol oxidase; AltName: Full=C-5 sterol desaturase; AltName: Full=Delta(7)-sterol 5-desaturase; AltName: Full=Lathosterol 5-desaturase; AltName: Full=Sterol-C5-desaturase [Mus musculus]

Related Sequences to LMP002954 proteins

Reference Database Accession Length Protein Name
GI:27777693 DBBJ BAA33730.1 299 sterol-C5-desaturase [Mus musculus]
GI:27777693 DBBJ BAE32506.1 299 unnamed protein product [Mus musculus]
GI:27777693 EMBL CAE83484.1 299 unnamed protein product [Mus musculus]
GI:27777693 GenBank AAH24132.1 299 Sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae) [Mus musculus]
GI:27777693 GenBank EDL25539.1 299 sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae) [Mus musculus]
GI:27777693 GenBank ADA21805.1 299 Sequence 8 from patent US 7608421