Gene/Proteome Database (LMPD)
Proteins
| arylsulfatase G isoform 1 precursor | |
|---|---|
| Refseq ID | NP_082986 |
| Protein GI | 261244940 |
| UniProt ID | Q3TYD4 |
| mRNA ID | NM_028710 |
| Length | 525 |
| RefSeq Status | VALIDATED |
| MGWLFLKVLLVGMAFSGFFYPLVDFSISGKTRAPQPNIVIILADDMGWGDLGANWAETKDTTNLDKMASEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNFAVTSVGGLPVNETTLAEVLRQEGYVTAMIGKWHLGHHGSYHPNFRGFDYYFGIPYSNDMGCTDAPGYNYPPCPACPQRDGLWRNPGRDCYTDVALPLYENLNIVEQPVNLSGLAQKYAERAVEFIEQASTSGRPFLLYVGLAHMHVPLSVTPPLAHPQRQSLYRASLREMDSLVGQIKDKVDHVARENTLLWFTGDNGPWAQKCELAGSVGPFFGLWQTHQGGSPTKQTTWEGGHRVPALAYWPGRVPANVTSTALLSLLDIFPTVIALAGASLPPNRKFDGRDVSEVLFGKSQMGHRVLFHPNSGAAGEYGALQTVRLNHYKAFYITGGAKACDGSVGPEQHHVAPLIFNLEDAADEGMPLQKGSPEYQEVLQQVTRALADVLQDIADDNSSRADYTQDPSVIPCCNPYQTTCRCQPV | |
| sig_peptide: 1..16 inference: non-experimental evidence, no additional details recorded note: Potential; propagated from UniProtKB/Swiss-Prot (Q3TYD4.1) calculated_mol_wt: 1812 peptide sequence: MGWLFLKVLLVGMAFS mat_peptide: 17..525 product: Arylsulfatase G experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q3TYD4.1) calculated_mol_wt: 55640 peptide sequence: GFFYPLVDFSISGKTRAPQPNIVIILADDMGWGDLGANWAETKDTTNLDKMASEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTHNFAVTSVGGLPVNETTLAEVLRQEGYVTAMIGKWHLGHHGSYHPNFRGFDYYFGIPYSNDMGCTDAPGYNYPPCPACPQRDGLWRNPGRDCYTDVALPLYENLNIVEQPVNLSGLAQKYAERAVEFIEQASTSGRPFLLYVGLAHMHVPLSVTPPLAHPQRQSLYRASLREMDSLVGQIKDKVDHVARENTLLWFTGDNGPWAQKCELAGSVGPFFGLWQTHQGGSPTKQTTWEGGHRVPALAYWPGRVPANVTSTALLSLLDIFPTVIALAGASLPPNRKFDGRDVSEVLFGKSQMGHRVLFHPNSGAAGEYGALQTVRLNHYKAFYITGGAKACDGSVGPEQHHVAPLIFNLEDAADEGMPLQKGSPEYQEVLQQVTRALADVLQDIADDNSSRADYTQDPSVIPCCNPYQTTCRCQPV | |
| arylsulfatase G isoform 2 | |
|---|---|
| Refseq ID | NP_001159649 |
| Protein GI | 261244942 |
| UniProt ID | Q3TYD4 |
| mRNA ID | NM_001166177 |
| Length | 202 |
| RefSeq Status | VALIDATED |
| MIKIGGSPTKQTTWEGGHRVPALAYWPGRVPANVTSTALLSLLDIFPTVIALAGASLPPNRKFDGRDVSEVLFGKSQMGHRVLFHPNSGAAGEYGALQTVRLNHYKAFYITGGAKACDGSVGPEQHHVAPLIFNLEDAADEGMPLQKGSPEYQEVLQQVTRALADVLQDIADDNSSRADYTQDPSVIPCCNPYQTTCRCQPV | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | ISS:HGNC | C | endoplasmic reticulum |
| GO:0005615 | IEA:Ensembl | C | extracellular space |
| GO:0005764 | ISS:UniProtKB | C | lysosome |
| GO:0004065 | ISS:UniProtKB | F | arylsulfatase activity |
| GO:0046872 | IEA:UniProtKB-KW | F | metal ion binding |
| GO:0006790 | IEA:Ensembl | P | sulfur compound metabolic process |
KEGG Pathway Links
REACTOME Pathway Links
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q3TYD4-1; Sequence=Displayed; Name=2; IsoId=Q3TYD4-2; Sequence=VSP_018628, VSP_018629; Note=No experimental confirmation available.; |
| Cofactor | Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000250}; |
| Function | Displays arylsulfatase activity with pseudosubstrates at acidic pH, such as p-nitrocatechol sulfate. {ECO:0000250}. |
| Ptm | Glycosylated. {ECO:0000250}. |
| Ptm | N-glycosylated. {ECO:0000250}. |
| Ptm | The conversion to 3-oxoalanine (also known as C- formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. {ECO:0000250}. |
| Similarity | Belongs to the sulfatase family. {ECO:0000305}. |
| Subcellular Location | Lysosome. Note=Previously observed endoplasmic reticulum localization is most likely due to folding/maturation problems for overexpressed proteins. {ECO:0000250}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP002969 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 261244940 | RefSeq | NP_082986 | 525 | arylsulfatase G isoform 1 precursor |
| 261244942 | RefSeq | NP_001159649 | 202 | arylsulfatase G isoform 2 |
Identical Sequences to LMP002969 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:261244942 | GenBank | AAH39629.1 | 202 | Arsg protein [Mus musculus] |
| GI:261244940 | RefSeq | XP_006534410.1 | 525 | PREDICTED: arylsulfatase G isoform X1 [Mus musculus] |
| GI:261244940 | RefSeq | XP_006534411.1 | 525 | PREDICTED: arylsulfatase G isoform X2 [Mus musculus] |
| GI:261244940 | RefSeq | XP_006534412.1 | 525 | PREDICTED: arylsulfatase G isoform X3 [Mus musculus] |
| GI:261244940 | RefSeq | XP_006534413.1 | 525 | PREDICTED: arylsulfatase G isoform X4 [Mus musculus] |
| GI:261244940 | SwissProt | Q3TYD4.1 | 525 | RecName: Full=Arylsulfatase G; Short=ASG; Flags: Precursor [Mus musculus] |
| GI:261244940 | tpe | CAI84993.1 | 525 | TPA: arylsulfatase G [Mus musculus] |
Related Sequences to LMP002969 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:261244940 | DBBJ | BAB31086.1 | 525 | unnamed protein product [Mus musculus] |
| GI:261244940 | DBBJ | BAD32360.1 | 512 | mKIAA1001 protein, partial [Mus musculus] |
| GI:261244942 | DBBJ | BAE34629.1 | 525 | unnamed protein product [Mus musculus] |
| GI:261244940 | GenBank | AAH84731.1 | 525 | Arylsulfatase G [Mus musculus] |
| GI:261244940 | GenBank | EDL34362.1 | 548 | arylsulfatase G, partial [Mus musculus] |
| GI:261244942 | RefSeq | NP_082986.3 | 525 | arylsulfatase G isoform 1 precursor [Mus musculus] |
| GI:261244940 | RefSeq | XP_006247661.1 | 526 | PREDICTED: arylsulfatase G isoform X1 [Rattus norvegicus] |
| GI:261244940 | RefSeq | XP_006247662.1 | 526 | PREDICTED: arylsulfatase G isoform X1 [Rattus norvegicus] |
| GI:261244942 | RefSeq | XP_006534410.1 | 525 | PREDICTED: arylsulfatase G isoform X1 [Mus musculus] |
| GI:261244942 | RefSeq | XP_006534411.1 | 525 | PREDICTED: arylsulfatase G isoform X2 [Mus musculus] |
| GI:261244942 | SwissProt | Q3TYD4.1 | 525 | RecName: Full=Arylsulfatase G; Short=ASG; Flags: Precursor [Mus musculus] |
| GI:261244942 | tpe | CAI84993.1 | 525 | TPA: arylsulfatase G [Mus musculus] |