Gene/Proteome Database (LMPD)
LMPD ID
LMP002981
Gene ID
Species
Homo sapiens (Human)
Gene Name
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
Gene Symbol
Synonyms
BETA3GALT2; GLCT2; beta3Gal-T2
Alternate Names
beta-1,3-galactosyltransferase 2; beta-3-galt2; beta-1,3-GalTase 2; UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase 2
Chromosome
1
Map Location
1q31
EC Number
2.4.1.-
Summary
This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene encodes a protein that functions in N-linked glycoprotein glycosylation and shows strict donor substrate specificity for UDP-galactose. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
beta-1,3-galactosyltransferase 2 | |
---|---|
Refseq ID | NP_003774 |
Protein GI | 4502339 |
UniProt ID | O43825 |
mRNA ID | NM_003783 |
Length | 422 |
RefSeq Status | REVIEWED |
MLQWRRRHCCFAKMTWNAKRSLFRTHLIGVLSLVFLFAMFLFFNHHDWLPGRAGFKENPVTYTFRGFRSTKSETNHSSLRNIWKETVPQTLRPQTATNSNNTDLSPQGVTGLENTLSANGSIYNEKGTGHPNSYHFKYIINEPEKCQEKSPFLILLIAAEPGQIEARRAIRQTWGNESLAPGIQITRIFLLGLSIKLNGYLQRAILEESRQYHDIIQQEYLDTYYNLTIKTLMGMNWVATYCPHIPYVMKTDSDMFVNTEYLINKLLKPDLPPRHNYFTGYLMRGYAPNRNKDSKWYMPPDLYPSERYPVFCSGTGYVFSGDLAEKIFKVSLGIRRLHLEDVYVGICLAKLRIDPVPPPNEFVFNHWRVSYSSCKYSHLITSHQFQPSELIKYWNHLQQNKHNACANAAKEKAGRYRHRKLH |
Gene Information
Entrez Gene ID
Gene Name
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0005794 | IEA:UniProtKB-KW | C | Golgi apparatus |
GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
GO:0008499 | TAS:ProtInc | F | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity |
GO:0009312 | IEA:Ensembl | P | oligosaccharide biosynthetic process |
GO:0006486 | TAS:ProtInc | P | protein glycosylation |
KEGG Pathway Links
Domain Information
InterPro Annotations
Accession | Description |
---|---|
IPR002659 | Glycosyl transferase, family 31 |
UniProt Annotations
Entry Information
Gene Name
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
Protein Entry
B3GT2_HUMAN
UniProt ID
Species
Human
Comments
Comment Type | Description |
---|---|
Cofactor | Name=Mn(2+); Xref=ChEBI |
Function | Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N- acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues. |
Pathway | Protein modification; protein glycosylation. |
Similarity | Belongs to the glycosyltransferase 31 family. |
Subcellular Location | Golgi apparatus membrane ; Single-pass type II membrane protein . |
Tissue Specificity | Detected in heart and brain. |
Web Resource | Name=Functional Glycomics Gateway - GTase; Note=Beta-1,3-galactosyltransferase 2; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_430"; |
Web Resource | Name=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B3GALT2"; |
Identical and Related Proteins
Unique RefSeq proteins for LMP002981 (as displayed in Record Overview)
Protein GI | Database | Accession | Length | Protein Name |
---|---|---|---|---|
4502339 | RefSeq | NP_003774 | 422 | beta-1,3-galactosyltransferase 2 |
Identical Sequences to LMP002981 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:4502339 | GenBank | AEJ66617.1 | 422 | Sequence 14 from patent US 7968293 |
GI:4502339 | GenBank | AIC50186.1 | 422 | B3GALT2, partial [synthetic construct] |
GI:4502339 | RefSeq | XP_003820650.1 | 422 | PREDICTED: beta-1,3-galactosyltransferase 2 [Pan paniscus] |
GI:4502339 | RefSeq | XP_003893417.1 | 422 | PREDICTED: beta-1,3-galactosyltransferase 2 [Papio anubis] |
GI:4502339 | RefSeq | XP_004028129.1 | 422 | PREDICTED: beta-1,3-galactosyltransferase 2-like [Gorilla gorilla gorilla] |
GI:4502339 | RefSeq | XP_004028130.1 | 422 | PREDICTED: beta-1,3-galactosyltransferase 2-like [Gorilla gorilla gorilla] |
Related Sequences to LMP002981 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:4502339 | EMBL | CAH92833.1 | 422 | hypothetical protein [Pongo abelii] |
GI:4502339 | GenBank | AAG60610.1 | 422 | B3GALT2 [Homo sapiens] |
GI:4502339 | GenBank | AFE64066.1 | 422 | beta-1,3-galactosyltransferase 2 [Macaca mulatta] |
GI:4502339 | RefSeq | NP_001248501.1 | 422 | beta-1,3-galactosyltransferase 2 [Macaca mulatta] |
GI:4502339 | RefSeq | XP_005540347.1 | 422 | PREDICTED: beta-1,3-galactosyltransferase 2 [Macaca fascicularis] |
GI:4502339 | SwissProt | Q5R5Y3.1 | 422 | RecName: Full=Beta-1,3-galactosyltransferase 2; Short=Beta-1,3-GalTase 2; Short=Beta3Gal-T2; Short=Beta3GalT2; AltName: Full=UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase 2 [Pongo abelii] |