Gene/Proteome Database (LMPD)

LMPD ID
LMP002981
Gene ID
Species
Homo sapiens (Human)
Gene Name
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
Gene Symbol
Synonyms
BETA3GALT2; GLCT2; beta3Gal-T2
Alternate Names
beta-1,3-galactosyltransferase 2; beta-3-galt2; beta-1,3-GalTase 2; UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase 2
Chromosome
1
Map Location
1q31
EC Number
2.4.1.-
Summary
This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene encodes a protein that functions in N-linked glycoprotein glycosylation and shows strict donor substrate specificity for UDP-galactose. [provided by RefSeq, Jul 2008]
Orthologs

Proteins

beta-1,3-galactosyltransferase 2
Refseq ID NP_003774
Protein GI 4502339
UniProt ID O43825
mRNA ID NM_003783
Length 422
RefSeq Status REVIEWED
MLQWRRRHCCFAKMTWNAKRSLFRTHLIGVLSLVFLFAMFLFFNHHDWLPGRAGFKENPVTYTFRGFRSTKSETNHSSLRNIWKETVPQTLRPQTATNSNNTDLSPQGVTGLENTLSANGSIYNEKGTGHPNSYHFKYIINEPEKCQEKSPFLILLIAAEPGQIEARRAIRQTWGNESLAPGIQITRIFLLGLSIKLNGYLQRAILEESRQYHDIIQQEYLDTYYNLTIKTLMGMNWVATYCPHIPYVMKTDSDMFVNTEYLINKLLKPDLPPRHNYFTGYLMRGYAPNRNKDSKWYMPPDLYPSERYPVFCSGTGYVFSGDLAEKIFKVSLGIRRLHLEDVYVGICLAKLRIDPVPPPNEFVFNHWRVSYSSCKYSHLITSHQFQPSELIKYWNHLQQNKHNACANAAKEKAGRYRHRKLH

Gene Information

Entrez Gene ID
Gene Name
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
Gene Symbol
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0008499 TAS:ProtInc F UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity
GO:0009312 IEA:Ensembl P oligosaccharide biosynthetic process
GO:0006486 TAS:ProtInc P protein glycosylation

KEGG Pathway Links

KEGG Pathway ID Description
hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series
M00070 Glycosphingolipid biosynthesis, lacto-series, LacCer => Lc4Cer
hsa01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR002659 Glycosyl transferase, family 31

UniProt Annotations

Entry Information

Gene Name
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
Protein Entry
B3GT2_HUMAN
UniProt ID
Species
Human

Comments

Comment Type Description
Cofactor Name=Mn(2+); Xref=ChEBI
Function Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N- acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues.
Pathway Protein modification; protein glycosylation.
Similarity Belongs to the glycosyltransferase 31 family.
Subcellular Location Golgi apparatus membrane ; Single-pass type II membrane protein .
Tissue Specificity Detected in heart and brain.
Web Resource Name=Functional Glycomics Gateway - GTase; Note=Beta-1,3-galactosyltransferase 2; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_430";
Web Resource Name=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B3GALT2";

Identical and Related Proteins

Unique RefSeq proteins for LMP002981 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4502339 RefSeq NP_003774 422 beta-1,3-galactosyltransferase 2

Identical Sequences to LMP002981 proteins

Reference Database Accession Length Protein Name
GI:4502339 GenBank AEJ66617.1 422 Sequence 14 from patent US 7968293
GI:4502339 GenBank AIC50186.1 422 B3GALT2, partial [synthetic construct]
GI:4502339 RefSeq XP_003820650.1 422 PREDICTED: beta-1,3-galactosyltransferase 2 [Pan paniscus]
GI:4502339 RefSeq XP_003893417.1 422 PREDICTED: beta-1,3-galactosyltransferase 2 [Papio anubis]
GI:4502339 RefSeq XP_004028129.1 422 PREDICTED: beta-1,3-galactosyltransferase 2-like [Gorilla gorilla gorilla]
GI:4502339 RefSeq XP_004028130.1 422 PREDICTED: beta-1,3-galactosyltransferase 2-like [Gorilla gorilla gorilla]

Related Sequences to LMP002981 proteins

Reference Database Accession Length Protein Name
GI:4502339 EMBL CAH92833.1 422 hypothetical protein [Pongo abelii]
GI:4502339 GenBank AAG60610.1 422 B3GALT2 [Homo sapiens]
GI:4502339 GenBank AFE64066.1 422 beta-1,3-galactosyltransferase 2 [Macaca mulatta]
GI:4502339 RefSeq NP_001248501.1 422 beta-1,3-galactosyltransferase 2 [Macaca mulatta]
GI:4502339 RefSeq XP_005540347.1 422 PREDICTED: beta-1,3-galactosyltransferase 2 [Macaca fascicularis]
GI:4502339 SwissProt Q5R5Y3.1 422 RecName: Full=Beta-1,3-galactosyltransferase 2; Short=Beta-1,3-GalTase 2; Short=Beta3Gal-T2; Short=Beta3GalT2; AltName: Full=UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase 2 [Pongo abelii]