Gene/Proteome Database (LMPD)

LMPD ID
LMP002998
Gene ID
79777
Species
Homo sapiens (Human)
Gene Name
acyl-CoA binding domain containing 4
Gene Symbol
ACBD4
Synonyms
-
Alternate Names
acyl-CoA-binding domain-containing protein 4; acyl-Coenzyme A binding domain containing 4
Chromosome
17
Map Location
17q21.31
Summary
This gene encodes a member of the acyl-coenzyme A binding domain containing protein family. All family members contain the conserved acyl-Coenzyme A binding domain, which binds acyl-CoA thiol esters. They are thought to play roles in acyl-CoA dependent lipid metabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Orthologs
View orthologs and multiple alignments for ACBD4

Proteins

acyl-CoA-binding domain-containing protein 4 isoform 1
Refseq ID NP_001129176
Protein GI 209364589
UniProt ID Q8NC06
mRNA ID NM_001135704
Length 341
RefSeq Status REVIEWED
MGTEKESPEPDCQKQFQAAVSVIQNLPKNGSYRPSYEEMLRFYSYYKQATMGPCLVPRPGFWDPIGRYKWDAWNSLGKMSREEAMSAYITEMKLVAQKVIDTVPLGEVAEDMFGYFEPLYQVIPDMPRPPETFLRRVTGWKEQVVNGDVGAVSEPPCLPKEPAPPSPASLWAVTLPTPPQSPIHPGTWTPRFSVIPWSSWSLSWFGQSSGQHLEESVIPGTAPCPPQRKRGCGAARRGPRSWTCGCWGQFEHYRRACRRCRRGCRAWRACPGPLSRGRSPGPVLGHGPLGSRGPRCSSSSCGPSSSSGSSECFGPKRGDCQWRGLCSQLRLSCCALSLPRV
acyl-CoA-binding domain-containing protein 4 isoform 1
Refseq ID NP_001129178
Protein GI 209364594
UniProt ID Q8NC06
mRNA ID NM_001135706
Length 341
RefSeq Status REVIEWED
Protein sequence is identical to GI:209364589 (mRNA isoform)
acyl-CoA-binding domain-containing protein 4 isoform 2
Refseq ID NP_078998
Protein GI 13376029
UniProt ID Q8NC06
mRNA ID NM_024722
Length 305
RefSeq Status REVIEWED
MGTEKESPEPDCQKQFQAAVSVIQNLPKNGSYRPSYEEMLRFYSYYKQATMGPCLVPRPGFWDPIGRYKWDAWNSLGKMSREEAMSAYITEMKLVAQKVIDTVPLGEVAEDMFGYFEPLYQVIPDMPRPPETFLRRVTGWKEQVVNGDVGAVSEPPCLPKEPAPPSPESHSPRDLDSEVFCDSLEQLEPELVWTEQRAASGGKRDPRNSPVPPTKKEGLRGSPPGPQELDVWLLGTVRALQESMQEVQARVQSLESMPRPPEQRPQPRPSARPWPLGLPGPALLFFLLWPFVVQWLFRMFRTQKR
acyl-CoA-binding domain-containing protein 4 isoform 2
Refseq ID NP_001129177
Protein GI 209364592
UniProt ID Q8NC06
mRNA ID NM_001135705
Length 305
RefSeq Status REVIEWED
Protein sequence is identical to GI:13376029 (mRNA isoform)
acyl-CoA-binding domain-containing protein 4 isoform 3
Refseq ID NP_001129179
Protein GI 209364600
UniProt ID Q8NC06
mRNA ID NM_001135707
Length 268
RefSeq Status REVIEWED
MGTEKESPEPDCQKQFQAAVSVIQNLPKNGSYRPSYEEMLRFYSYYKQATMGPCLVPRPGFWDPIGRYKWDAWNSLGKMSREEAMSAYITEMKLVAQKVIDTVPLGEVAEDMFGYFEPLYQVIPDMPRPPETFLRRVTGWKEQVVNGDVGAVSEPPCLPKEPAPPSPESHSPRDLDSEVFCDSLEQLEPELSSGQHLEESVIPGTAPCPPQRKRGCGAARRGPRSWTCGCWGQFEHYRRACRRCRRGCRAWRACPGPLSSLTLSVRLE

Gene Information

Entrez Gene ID
79777
Gene Name
acyl-CoA binding domain containing 4
Gene Symbol
ACBD4
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000062 IEA:InterPro F fatty-acyl-CoA binding
GO:0008289 IEA:UniProtKB-KW F lipid binding

Domain Information

InterPro Annotations

Accession Description
IPR000582 Acyl-CoA-binding protein, ACBP
IPR022408 Acyl-CoA-binding protein, ACBP, conserved site
IPR014352 FERM/acyl-CoA-binding protein, 3-helical bundle

UniProt Annotations

Entry Information

Gene Name
acyl-CoA binding domain containing 4
Protein Entry
ACBD4_HUMAN
UniProt ID
Q8NC06
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8NC06-1; Sequence=Displayed; Name=2; IsoId=Q8NC06-2; Sequence=VSP_014089; Name=3; IsoId=Q8NC06-3; Sequence=VSP_014088, VSP_014090;
Function Binds medium- and long-chain acyl-CoA esters and may function as an intracellular carrier of acyl-CoA esters.
Similarity Contains 1 ACB (acyl-CoA-binding) domain.

Identical and Related Proteins

Unique RefSeq proteins for LMP002998 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
209364589 RefSeq NP_001129176 341 acyl-CoA-binding domain-containing protein 4 isoform 1
13376029 RefSeq NP_078998 305 acyl-CoA-binding domain-containing protein 4 isoform 2
209364600 RefSeq NP_001129179 268 acyl-CoA-binding domain-containing protein 4 isoform 3

Identical Sequences to LMP002998 proteins

Reference Database Accession Length Protein Name
GI:209364589 DBBJ BAD38638.1 341 putative protein product of HMFT0700 [Homo sapiens]
GI:13376029 EMBL CAE90961.1 305 unnamed protein product [Homo sapiens]
GI:209364589 GenBank AAH41143.1 341 ACBD4 protein [Homo sapiens]
GI:13376029 GenBank EAW51550.1 305 acyl-Coenzyme A binding domain containing 4, isoform CRA_c [Homo sapiens]
GI:13376029 GenBank EAW51551.1 305 acyl-Coenzyme A binding domain containing 4, isoform CRA_c [Homo sapiens]
GI:13376029 GenBank EAW51552.1 305 acyl-Coenzyme A binding domain containing 4, isoform CRA_c [Homo sapiens]
GI:209364589 GenBank ADQ33037.1 341 acyl-Coenzyme A binding domain containing 4, partial [synthetic construct]
GI:13376029 GenBank AIC63569.1 305 ACBD4, partial [synthetic construct]
GI:13376029 RefSeq NP_001129177.1 305 acyl-CoA-binding domain-containing protein 4 isoform 2 [Homo sapiens]
GI:209364589 RefSeq NP_001129178.1 341 acyl-CoA-binding domain-containing protein 4 isoform 1 [Homo sapiens]
GI:209364589 RefSeq XP_005257734.1 341 PREDICTED: acyl-CoA-binding domain-containing protein 4 isoform X5 [Homo sapiens]
GI:209364600 SwissProt Q8NC06.2 268 RecName: Full=Acyl-CoA-binding domain-containing protein 4 [Homo sapiens]

Related Sequences to LMP002998 proteins

Reference Database Accession Length Protein Name
GI:209364600 DBBJ BAC11403.1 268 unnamed protein product [Homo sapiens]
GI:209364589 DBBJ BAG58905.1 341 unnamed protein product [Homo sapiens]
GI:209364589 DBBJ BAH14730.1 341 unnamed protein product [Homo sapiens]
GI:209364600 EMBL CAF86344.1 268 unnamed protein product [Homo sapiens]
GI:13376029 GenBank JAA25490.1 305 acyl-Coenzyme A binding domain containing 4 [Pan troglodytes]
GI:13376029 GenBank JAA39598.1 305 acyl-Coenzyme A binding domain containing 4 [Pan troglodytes]
GI:209364589 GenBank AIC57109.1 341 ACBD4, partial [synthetic construct]
GI:209364589 RefSeq XP_004041557.1 341 PREDICTED: acyl-CoA-binding domain-containing protein 4 isoform 1 [Gorilla gorilla gorilla]
GI:13376029 RefSeq XP_004041558.1 305 PREDICTED: acyl-CoA-binding domain-containing protein 4 isoform 2 [Gorilla gorilla gorilla]
GI:209364589 RefSeq XP_005257730.1 342 PREDICTED: acyl-CoA-binding domain-containing protein 4 isoform X1 [Homo sapiens]
GI:209364589 RefSeq XP_005257731.1 342 PREDICTED: acyl-CoA-binding domain-containing protein 4 isoform X2 [Homo sapiens]
GI:13376029 RefSeq XP_006722148.1 306 PREDICTED: acyl-CoA-binding domain-containing protein 4 isoform X6 [Homo sapiens]
GI:209364600 RefSeq XP_008010535.1 326 PREDICTED: acyl-CoA-binding domain-containing protein 4 isoform X1 [Chlorocebus sabaeus]
GI:209364600 RefSeq XP_009189105.1 326 PREDICTED: acyl-CoA-binding domain-containing protein 4 isoform X1 [Papio anubis]
GI:209364600 RefSeq XP_009249894.1 330 PREDICTED: acyl-CoA-binding domain-containing protein 4 isoform X1 [Pongo abelii]
GI:13376029 RefSeq XP_009249896.1 305 PREDICTED: acyl-CoA-binding domain-containing protein 4 isoform X3 [Pongo abelii]
GI:209364600 RefSeq XP_009430211.1 330 PREDICTED: acyl-CoA-binding domain-containing protein 4 isoform X3 [Pan troglodytes]
GI:13376029 RefSeq XP_009430214.1 305 PREDICTED: acyl-CoA-binding domain-containing protein 4 isoform X6 [Pan troglodytes]