Gene/Proteome Database (LMPD)

LMPD ID
LMP003096
Gene ID
18786
Species
Mus musculus (Mouse)
Gene Name
phospholipase A2, activating protein
Gene Symbol
Plaa
Synonyms
2410007N06; AI536418; AU018445; AW208417; D4Ertd618e; PLA2P; PLAP; Ufd3
Alternate Names
phospholipase A-2-activating protein
Chromosome
4
Map Location
4 C5|4 43.34 cM

Proteins

phospholipase A-2-activating protein
Refseq ID NP_766283
Protein GI 114431250
UniProt ID P27612
mRNA ID NM_172695
Length 794
RefSeq Status VALIDATED
MASGASRYRLSCSLPGHELDVRGLVCCLYPPGAFVSVSRDRTTRLWAPDSPNRGFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKDTVCSLSSGKFGTLLSGSWDTTAKVWLNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTIKLWKAGRCERTFLGHEDCVRGLAILSETEFLSCANDASIRRWQITGECLEVYFGHTNYIYSISVFPNSKDFVTTAEDRSLRIWKHGECAQTIRLPAQSIWCCCVLENGDIVVGASDGIIRVFTESEERTASAEEIKAFERELSQATIDSKTGDLGDINAEQLPGREHLSEPGTREGQTRLIRDGERVEAYQWSVSDGRWIKIGDVVGSSGANQQTSGKVLYEGKEFDYVFSIDVNEGGPSYKLPYNVSDDPWLVAYNFLQKNDLNPMFLDQVAKFIIDNTKGQTLGLGNTSFSDPFTGGGRYVPGTSGPSNTVQTADPFTGAGRYMPGSAGMDTTMTGVDPFTGNSAYRSAASKTVNIYFPKKEALTFDQANPTQILGKLKELNGTAPEEKKLTEDDLVLLEKILSLICNNSSEKPTAQQLQILWKAINWPEDIVFPALDILRLSIKHPNVNENFCNEKGDQFSSHLINLLNPKGKPANQLLALRTFCNCFVSQAGQKLMMSQRESLMSHAIELKSGSNKNIHIALATLTLNYSVCFHKDHNIEGKAQCLSVISTILEVVQDLEATFRLLVALGTLISDDSNAIQLAKSLGVDSQIKKYVSVSEPAKVSECCRLVLHLL

Gene Information

Entrez Gene ID
18786
Gene Name
phospholipase A2, activating protein
Gene Symbol
Plaa
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0016005 IDA:MGI F phospholipase A2 activator activity
GO:0006954 IDA:MGI P inflammatory response
GO:0043085 IDA:GOC P positive regulation of catalytic activity

KEGG Pathway Links

KEGG Pathway ID Description
ko04141 Protein processing in endoplasmic reticulum
mmu04141 Protein processing in endoplasmic reticulum

Domain Information

InterPro Annotations

Accession Description
IPR015155 PLAA family ubiquitin binding, PFU
IPR013535 PUL
IPR017986 WD40-repeat-containing domain
IPR015943 WD40/YVTN repeat-like-containing domain
IPR001680 WD40_repeat

UniProt Annotations

Entry Information

Gene Name
phospholipase A2, activating protein
Protein Entry
PLAP_MOUSE
UniProt ID
P27612
Species
Mouse

Comments

Comment Type Description
Domain The PFU domain mediates interaction with ubiquitin. {ECO:0000250}.
Domain The PUL domain is composed of 6 armadillo-like repeats and mediates the interaction with VCP C-terminus. {ECO:0000250}.
Function Involved in the maintenance of ubiquitin levels. {ECO:0000250}.
Induction In smooth muscle and endothelial cells by leukotriene D4, by tumor necrosis factor in endothelial cells and by uric acid crystals in macrophages.
Sequence Caution Sequence=AAA39943.1; Type=Miscellaneous discrepancy; Note=Several frameshifts and contaminating sequence.; Evidence={ECO:0000305}; Sequence=Ref.3; Type=Frameshift; Positions=697; Evidence={ECO:0000305};
Similarity Belongs to the WD repeat PLAP family. {ECO:0000305}.
Similarity Contains 1 PFU domain. {ECO:0000255|PROSITE- ProRule:PRU00727}.
Similarity Contains 1 PUL domain. {ECO:0000255|PROSITE- ProRule:PRU00729}.
Similarity Contains 6 ARM repeats. {ECO:0000305}.
Similarity Contains 7 WD repeats. {ECO:0000255|PROSITE- ProRule:PRU00221}.
Subunit Interacts with ubiquitin. Interacts with VCP (By similarity). {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP003096 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
114431250 RefSeq NP_766283 794 phospholipase A-2-activating protein

Identical Sequences to LMP003096 proteins

Reference Database Accession Length Protein Name
GI:114431250 GenBank AAI39774.1 794 Phospholipase A2, activating protein [Mus musculus]
GI:114431250 GenBank EDL30936.1 794 phospholipase A2, activating protein, isoform CRA_a [Mus musculus]
GI:114431250 GenBank AAI39357.1 794 Phospholipase A2, activating protein [Mus musculus]
GI:114431250 GenBank AAI39356.1 794 Phospholipase A2, activating protein [Mus musculus]
GI:114431250 SwissProt P27612.4 794 RecName: Full=Phospholipase A-2-activating protein; Short=PLA2P; Short=PLAP [Mus musculus]

Related Sequences to LMP003096 proteins

Reference Database Accession Length Protein Name
GI:114431250 DBBJ BAC36064.1 794 unnamed protein product [Mus musculus]
GI:114431250 GenBank EDL30938.1 845 phospholipase A2, activating protein, isoform CRA_c, partial [Mus musculus]
GI:114431250 GenBank EDL97755.1 844 phospholipase A2, activating protein, isoform CRA_a [Rattus norvegicus]
GI:114431250 GenBank EDL97756.1 795 phospholipase A2, activating protein, isoform CRA_b [Rattus norvegicus]
GI:114431250 RefSeq NP_446318.3 795 phospholipase A-2-activating protein [Rattus norvegicus]
GI:114431250 SwissProt P54319.3 795 RecName: Full=Phospholipase A-2-activating protein; Short=PLA2P; Short=PLAP [Rattus norvegicus]