Gene/Proteome Database (LMPD)

LMPD ID
LMP003111
Gene ID
234515
Species
Mus musculus (Mouse)
Gene Name
inositol polyphosphate-4-phosphatase, type II
Gene Symbol
Inpp4b
Synonyms
E130107I17Rik
Chromosome
8
Map Location
8 C2|8 39.02 cM

Proteins

type II inositol 3,4-bisphosphate 4-phosphatase isoform 1
Refseq ID NP_001284520
Protein GI 662236796
UniProt ID Q3URI3
mRNA ID NM_001297591
Length 941
RefSeq Status VALIDATED
MEIKEEGTSEEGQHFLPAAQANDPEDIQFTSIQKIPNEPQLEFILACRDLVAPVSDRKLNTVVQISVIHPVEQTLTRYSSTEIVEGTKDPLFLTGVTFPPDYPIYEETRIKLTVYDVKDKSHDTIRTSVLPEHKDPLPEVARSFLGCASFKVGELLKSKEQLLSLSLRTSDGGKVVGTIEVSLVKMGEIEDGDTDHITTDVQGQKCALMYESTAPESLSGKENLPFMNAVLRNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQELKELGDLSPHWDNLRKNVLSHCDQMVTMYQDILTELSKETGSSFKSSSSKGEKTLEFVPVNLHLQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTGYQFIYYSPENTAKAKEVLSSINQLQPLIATHADLLLTSASQRSPDSLKSSLKLLSEKTELFVHAFKDQLVRSALLALYTARPGGILKKPPSPNVSTEEKSTQHDTPQLRRQDSIPHHSDYDEEEWDRVWANVGKSLNCIIAKVDKLIERDSHNEEGAGGSSSKDGEADHTLEDSITSHPREDWYEQLHPLILTLKECMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLHTSLHDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAVGISDLRKVAFKITEATSNDVLPVLTGRREHYVVEVKLPATVFESLPLQIKEGQLLHVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELVQEYYSIFMEKMPPDYISHFQEQTDLKGLLDNLHQNIQAKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRSRQTQGALNESDDPETGCLTDNKPTSRHFYPVALLLVSSHLLVVWLILSLALLLAKYQ
type II inositol 3,4-bisphosphate 4-phosphatase isoform 2
Refseq ID NP_001019788
Protein GI 71725387
UniProt ID Q6P1Y8
mRNA ID NM_001024617
Length 924
RefSeq Status VALIDATED
MEIKEEGTSEEGQHFLPAAQANDPEDIQFTSIQKIPNEPQLEFILACRDLVAPVSDRKLNTVVQISVIHPVEQTLTRYSSTEIVEGTKDPLFLTGVTFPPDYPIYEETRIKLTVYDVKDKSHDTRSFLGCASFKVGELLKSKEQLLSLSLRTSDGGKVVGTIEVSLVKMGEIEDGDTDHITTDVQGQKCALMYESTAPESLSGKENLPFMNAVLRNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQELKELGDLSPHWDNLRKNVLSHCDQMVTMYQDILTELSKETGSSFKSSSSKGEKTLEFVPVNLHLQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTGYQFIYYSPENTAKAKEVLSSINQLQPLIATHADLLLTSASQRSPDSLKSSLKLLSEKTELFVHAFKDQLVRSALLALYTARPGGILKKPPSPNVSTEEKSTQHDTPQLRRQDSIPHHSDYDEEEWDRVWANVGKSLNCIIAKVDKLIERDSHNEEGAGGSSSKDGEADHTLEDSITSHPREDWYEQLHPLILTLKECMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLHTSLHDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAVGISDLRKVAFKITEATSNDVLPVLTGRREHYVVEVKLPATVFESLPLQIKEGQLLHVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELVQEYYSIFMEKMPPDYISHFQEQTDLKGLLDNLHQNIQAKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRSRQTQGALNESDDPETGCLTDNKPTSRHFYPVALLLVSSHLLVVWLILSLALLLAKYQ
type II inositol 3,4-bisphosphate 4-phosphatase isoform 3
Refseq ID NP_001284522
Protein GI 662236812
UniProt ID Q3URI3
mRNA ID NM_001297593
Length 866
RefSeq Status VALIDATED
MTLRTFSLPASRRFRTSHSWNSFSGTKDPLFLTGVTFPPDYPIYEETRIKLTVYDVKDKSHDTIRTSVLPEHKDPLPEVARSFLGCASFKVGELLKSKEQLLSLSLRTSDGGKVVGTIEVSLVKMGEIEDGDTDHITTDVQGQKCALMYESTAPESLSGKENLPFMNAVLRNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQELKELGDLSPHWDNLRKNVLSHCDQMVTMYQDILTELSKETGSSFKSSSSKGEKTLEFVPVNLHLQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTGYQFIYYSPENTAKAKEVLSSINQLQPLIATHADLLLTSASQRSPDSLKSSLKLLSEKTELFVHAFKDQLVRSALLALYTARPGGILKKPPSPNVSTEEKSTQHDTPQLRRQDSIPHHSDYDEEEWDRVWANVGKSLNCIIAKVDKLIERDSHNEEGAGGSSSKDGEADHTLEDSITSHPREDWYEQLHPLILTLKECMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLHTSLHDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAVGISDLRKVAFKITEATSNDVLPVLTGRREHYVVEVKLPATVFESLPLQIKEGQLLHVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELVQEYYSIFMEKMPPDYISHFQEQTDLKGLLDNLHQNIQAKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRREGCRIENVLKNIKCRRYAFNMLQLMAFPKCYRPPEGTYGKADT
type II inositol 3,4-bisphosphate 4-phosphatase isoform 4
Refseq ID NP_001284525
Protein GI 662236823
UniProt ID Q3URI3
mRNA ID NM_001297596
Length 927
RefSeq Status VALIDATED
MEIKEEGTSEEGQHFLPAAQANDPEDIQFTSIQKIPNEPQLEFILACRDLVAPVSDRKLNTVVQISVIHPVEQTLTRYSSTEIVEGTKDPLFLTGVTFPPDYPIYEETRIKLTVYDVKDKSHDTIRTSVLPEHKDPLPEVARSFLGCASFKVGELLKSKEQLLSLSLRTSDGGKVVGTIEVSLVKMGEIEDGDTDHITTDVQGQKCALMYESTAPESLSGKENLPFMNAVLRNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQELKELGDLSPHWDNLRKNVLSHCDQMVTMYQDILTELSKETGSSFKSSSSKGEKTLEFVPVNLHLQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTGYQFIYYSPENTAKAKEVLSSINQLQPLIATHADLLLTSASQRSPDSLKSSLKLLSEKTELFVHAFKDQLVRSALLALYTARPGGILKKPPSPNVSTEEKSTQHDTPQLRRQDSIPHHSDYDEEEWDRVWANVGKSLNCIIAKVDKLIERDSHNEEGAGGSSSKDGEADHTLEDSITSHPREDWYEQLHPLILTLKECMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLHTSLHDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAVGISDLRKVAFKITEATSNDVLPVLTGRREHYVVEVKLPATVFESLPLQIKEGQLLHVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELVQEYYSIFMEKMPPDYISHFQEQTDLKGLLDNLHQNIQAKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRREGCRIENVLKNIKCRRYAFNMLQLMAFPKCYRPPEGTYGKADT

Gene Information

Entrez Gene ID
234515
Gene Name
inositol polyphosphate-4-phosphatase, type II
Gene Symbol
Inpp4b
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:MGI C cytoplasm
GO:0005794 IDA:MGI C Golgi apparatus
GO:0008289 IDA:MGI F lipid binding
GO:0016316 IEA:UniProtKB-EC F phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
GO:0034597 IEA:UniProtKB-EC F phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity
GO:0034593 IDA:MGI F phosphatidylinositol bisphosphate phosphatase activity
GO:0034594 IDA:MGI F phosphatidylinositol trisphosphate phosphatase activity
GO:0006874 IGI:MGI P cellular calcium ion homeostasis
GO:0016311 IDA:GOC P dephosphorylation
GO:0045671 IMP:MGI P negative regulation of osteoclast differentiation
GO:0046850 IMP:MGI P regulation of bone remodeling
GO:0046822 IMP:MGI P regulation of nucleocytoplasmic transport
GO:0051896 IMP:MGI P regulation of protein kinase B signaling

KEGG Pathway Links

KEGG Pathway ID Description
ko00562 Inositol phosphate metabolism
mmu00562 Inositol phosphate metabolism
M00131 Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositol
mmu01100 Metabolic pathways
ko04070 Phosphatidylinositol signaling system
mmu04070 Phosphatidylinositol signaling system

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY3DJ-219 PIP metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5894026 Inositol phosphate metabolism
5892760 Metabolism
5892799 Metabolism of lipids and lipoproteins
5892984 Phospholipid metabolism
5893988 PI Metabolism
5894027 Synthesis of IP2, IP, and Ins in the cytosol
5894013 Synthesis of PIPs at the early endosome membrane
5894009 Synthesis of PIPs at the plasma membrane

Domain Information

InterPro Annotations

Accession Description
IPR000008 C2 domain

UniProt Annotations

Entry Information

Gene Name
inositol polyphosphate-4-phosphatase, type II
Protein Entry
INP4B_MOUSE
UniProt ID
Q6P1Y8
Species
Mouse

Comments

Comment Type Description
Catalytic Activity 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.
Enzyme Regulation Strongly inhibited by inositol hexakisphosphate. {ECO:0000250}.
Function Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 1,4-bisphosphate. {ECO:0000250}.
Pathway Signal transduction; phosphatidylinositol signaling pathway.
Similarity Belongs to the inositol 3,4-bisphosphate 4-phosphatase family. {ECO:0000305}.
Similarity Contains 1 C2 domain. {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP003111 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
662236796 RefSeq NP_001284520 941 type II inositol 3,4-bisphosphate 4-phosphatase isoform 1
71725387 RefSeq NP_001019788 924 type II inositol 3,4-bisphosphate 4-phosphatase isoform 2
662236812 RefSeq NP_001284522 866 type II inositol 3,4-bisphosphate 4-phosphatase isoform 3
662236823 RefSeq NP_001284525 927 type II inositol 3,4-bisphosphate 4-phosphatase isoform 4

Identical Sequences to LMP003111 proteins

Reference Database Accession Length Protein Name
GI:71725387 GenBank AAH64813.1 924 Inositol polyphosphate-4-phosphatase, type II [Mus musculus]
GI:662236796 RefSeq XP_006530917.1 941 PREDICTED: type II inositol 3,4-bisphosphate 4-phosphatase isoform X1 [Mus musculus]
GI:662236796 RefSeq XP_006530918.1 941 PREDICTED: type II inositol 3,4-bisphosphate 4-phosphatase isoform X2 [Mus musculus]
GI:662236796 RefSeq XP_006530919.1 941 PREDICTED: type II inositol 3,4-bisphosphate 4-phosphatase isoform X3 [Mus musculus]
GI:662236796 RefSeq XP_006530920.1 941 PREDICTED: type II inositol 3,4-bisphosphate 4-phosphatase isoform X4 [Mus musculus]
GI:662236823 RefSeq XP_006530921.1 927 PREDICTED: type II inositol 3,4-bisphosphate 4-phosphatase isoform X5 [Mus musculus]
GI:71725387 SwissProt Q6P1Y8.1 924 RecName: Full=Type II inositol 3,4-bisphosphate 4-phosphatase; AltName: Full=Inositol polyphosphate 4-phosphatase type II [Mus musculus]

Related Sequences to LMP003111 proteins

Reference Database Accession Length Protein Name
GI:662236823 GenBank AAB72151.1 928 inositol polyphosphate 4-phosphatase type II-alpha [Rattus norvegicus]
GI:662236796 GenBank AAH64813.1 924 Inositol polyphosphate-4-phosphatase, type II [Mus musculus]
GI:662236823 GenBank ABC33848.1 927 inositol polyphosphate 4-phosphatase type II alpha isoform [Mus musculus]
GI:662236812 GenBank ABC33848.1 927 inositol polyphosphate 4-phosphatase type II alpha isoform [Mus musculus]
GI:662236812 GenBank ABC33849.1 866 inositol polyphosphate 4-phosphatase type II alpha short isoform [Mus musculus]
GI:662236796 GenBank ABC33850.1 941 inositol polyphosphate 4-phosphatase type II beta isoform [Mus musculus]
GI:71725387 GenBank ABC33850.1 941 inositol polyphosphate 4-phosphatase type II beta isoform [Mus musculus]
GI:662236812 GenBank EDL92293.1 928 inositol polyphosphate-4-phosphatase, type II, isoform CRA_a [Rattus norvegicus]
GI:662236823 GenBank EDL92293.1 928 inositol polyphosphate-4-phosphatase, type II, isoform CRA_a [Rattus norvegicus]
GI:662236796 RefSeq NP_446369.1 942 type II inositol 3,4-bisphosphate 4-phosphatase [Rattus norvegicus]
GI:662236796 RefSeq NP_001019788.1 924 type II inositol 3,4-bisphosphate 4-phosphatase isoform 2 [Mus musculus]
GI:71725387 RefSeq XP_006530917.1 941 PREDICTED: type II inositol 3,4-bisphosphate 4-phosphatase isoform X1 [Mus musculus]
GI:71725387 RefSeq XP_006530918.1 941 PREDICTED: type II inositol 3,4-bisphosphate 4-phosphatase isoform X2 [Mus musculus]
GI:71725387 RefSeq XP_006530919.1 941 PREDICTED: type II inositol 3,4-bisphosphate 4-phosphatase isoform X3 [Mus musculus]
GI:71725387 RefSeq XP_006530920.1 941 PREDICTED: type II inositol 3,4-bisphosphate 4-phosphatase isoform X4 [Mus musculus]
GI:662236812 RefSeq XP_006530921.1 927 PREDICTED: type II inositol 3,4-bisphosphate 4-phosphatase isoform X5 [Mus musculus]
GI:662236812 RefSeq XP_006530924.1 880 PREDICTED: type II inositol 3,4-bisphosphate 4-phosphatase isoform X8 [Mus musculus]
GI:71725387 RefSeq NP_001284520.1 941 type II inositol 3,4-bisphosphate 4-phosphatase isoform 1 [Mus musculus]
GI:662236812 RefSeq NP_001284525.1 927 type II inositol 3,4-bisphosphate 4-phosphatase isoform 4 [Mus musculus]
GI:662236796 RefSeq XP_008770684.1 942 PREDICTED: type II inositol 3,4-bisphosphate 4-phosphatase isoform X1 [Rattus norvegicus]
GI:662236823 RefSeq XP_008770685.1 928 PREDICTED: type II inositol 3,4-bisphosphate 4-phosphatase isoform X2 [Rattus norvegicus]
GI:662236823 RefSeq XP_008770686.1 928 PREDICTED: type II inositol 3,4-bisphosphate 4-phosphatase isoform X2 [Rattus norvegicus]
GI:662236796 SwissProt Q6P1Y8.1 924 RecName: Full=Type II inositol 3,4-bisphosphate 4-phosphatase; AltName: Full=Inositol polyphosphate 4-phosphatase type II [Mus musculus]
GI:662236823 SwissProt Q9QWG5.1 928 RecName: Full=Type II inositol 3,4-bisphosphate 4-phosphatase; AltName: Full=Inositol polyphosphate 4-phosphatase type II [Rattus norvegicus]