Gene/Proteome Database (LMPD)

LMPD ID
LMP003113
Gene ID
353371
Species
Mus musculus (Mouse)
Gene Name
3-oxoacid CoA transferase 2B
Gene Symbol
Oxct2b
Synonyms
Scot-t2
Alternate Names
succinyl-CoA:3-ketoacid coenzyme A transferase 2B, mitochondrial; 3-oxoacid CoA-transferase 2B; 3-oxoacid-CoA transferase 2B; succinyl CoA:3-oxoacid CoA-transferase; testis-specific succinyl CoA:3-oxoacid CoA-transferase 2; testis-specific succinyl-CoA:3-oxoacid CoA-transferase 2; succinyl-CoA:3-ketoacid-coenzyme A transferase 2B, mitochondrial
Chromosome
4
Map Location
4 D2.2|4
EC Number
2.8.3.5

Proteins

succinyl-CoA:3-ketoacid coenzyme A transferase 2B, mitochondrial precursor
Refseq ID NP_862907
Protein GI 160358827
UniProt ID Q9ESL0
mRNA ID NM_181859
Length 520
RefSeq Status VALIDATED
MAALRLLAWALPRGVSALRPRPALPHRLIRRYVSDRSGSVHFYTDPVKAVEGVKDGSTVMLGGFGLCGIPENLIGALKTKGVKDLKIVSSNVGVDDFGLGILLASKQVRRVVCSYLGENALCEKLYLAGELELEMTPQGTLAERIRAGGTGVPAFYTPTGYGTLVQEGGSPIRYAPDGHLITLSEPREVREFQGRFYLLEHAIRADFALIKGWKADRSGNVIFRGSARNFNVPMCKAADISVVEVEEIVDVGTFAPEDIHIPNIYVDRVIKGPKFEKRIERLTTRDSKPAPGSKDNDPSRTRIIKRAALEFQDGMYANLGIGIPVLASNYISPKMTVYLHSENGILGLGPFPLKNEVDADVINAGKQTVTVVPGGCFFASDDSFAMIRGGHLQLTMLGAMQVSQYGDLANWMVPGKKVKGMGGAMDLVSSKKTRVVVTMEHCTKTKQPKILKKCTMPLTGKRCVDLIITEKAVFEVNHSKGLTLVELWEGSSVDDIKATTACSFAVSPNLKPMQQIKLDA
transit_peptide: 1..39 calculated_mol_wt: 4381 peptide sequence: MAALRLLAWALPRGVSALRPRPALPHRLIRRYVSDRSGS mat_peptide: 40..520 product: succinyl-CoA:3-ketoacid coenzyme A transferase 2B, mitochondrial calculated_mol_wt: 52183 peptide sequence: VHFYTDPVKAVEGVKDGSTVMLGGFGLCGIPENLIGALKTKGVKDLKIVSSNVGVDDFGLGILLASKQVRRVVCSYLGENALCEKLYLAGELELEMTPQGTLAERIRAGGTGVPAFYTPTGYGTLVQEGGSPIRYAPDGHLITLSEPREVREFQGRFYLLEHAIRADFALIKGWKADRSGNVIFRGSARNFNVPMCKAADISVVEVEEIVDVGTFAPEDIHIPNIYVDRVIKGPKFEKRIERLTTRDSKPAPGSKDNDPSRTRIIKRAALEFQDGMYANLGIGIPVLASNYISPKMTVYLHSENGILGLGPFPLKNEVDADVINAGKQTVTVVPGGCFFASDDSFAMIRGGHLQLTMLGAMQVSQYGDLANWMVPGKKVKGMGGAMDLVSSKKTRVVVTMEHCTKTKQPKILKKCTMPLTGKRCVDLIITEKAVFEVNHSKGLTLVELWEGSSVDDIKATTACSFAVSPNLKPMQQIKLDA

Gene Information

Entrez Gene ID
353371
Gene Name
3-oxoacid CoA transferase 2B
Gene Symbol
Oxct2b
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IDA:MGI C mitochondrion
GO:0031514 ISA:MGI C motile cilium
GO:0008260 IEA:UniProtKB-EC F 3-oxoacid CoA-transferase activity
GO:0006091 TAS:MGI P generation of precursor metabolites and energy
GO:0046952 IEA:InterPro P ketone body catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00650 Butanoate metabolism
mmu00072 Synthesis and degradation of ketone bodies
mmu00280 Valine, leucine and isoleucine degradation

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY66-368 ketolysis

Domain Information

InterPro Annotations

Accession Description
IPR014388 3-oxoacid_CoA-transferase
IPR012792 3-oxoacid CoA-transferase, subunit A
IPR012791 3-oxoacid CoA-transferase, subunit B
IPR004164 Coenzyme A transferase active site
IPR004163 Coenzyme A transferase binding site
IPR004165 Coenzyme A transferase family I

UniProt Annotations

Entry Information

Gene Name
3-oxoacid CoA transferase 2B
Protein Entry
SCO2B_MOUSE
UniProt ID
Q9ESL0
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Succinyl-CoA + a 3-oxo acid = succinate + a 3- oxoacyl-CoA. {ECO:0000255|PROSITE-ProRule:PRU10034}.
Function Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). Probably play and important roles in the energy metabolism of spermatozoa. {ECO:0000250}.
Pathway Ketone metabolism; succinyl-CoA degradation; acetoacetyl- CoA from succinyl-CoA: step 1/1.
Similarity Belongs to the 3-oxoacid CoA-transferase family. {ECO:0000305}.
Subcellular Location Mitochondrion {ECO:0000250}.
Subunit Homodimer. {ECO:0000250}.
Tissue Specificity Testis specific. Expressed in late spermatids. Accumulates during spermiogenesis. Also detected in the midpiece of spermatozoa. {ECO:0000269|PubMed:11090426}.

Identical and Related Proteins

Unique RefSeq proteins for LMP003113 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
160358827 RefSeq NP_862907 520 succinyl-CoA:3-ketoacid coenzyme A transferase 2B, mitochondrial precursor

Identical Sequences to LMP003113 proteins

Reference Database Accession Length Protein Name
GI:160358827 GenBank AAI13759.1 520 3-oxoacid CoA transferase 2B [Mus musculus]

Related Sequences to LMP003113 proteins

Reference Database Accession Length Protein Name
GI:160358827 DBBJ BAC36595.1 520 unnamed protein product [Mus musculus]
GI:160358827 DBBJ BAC87737.1 520 succinyl-CoA:3-oxoacid CoA-transferase [Mus musculus]
GI:160358827 GenBank AAI37889.1 520 3-oxoacid CoA transferase 2A [Mus musculus]
GI:160358827 GenBank AAI37888.1 520 3-oxoacid CoA transferase 2A [Mus musculus]
GI:160358827 RefSeq NP_071316.1 520 succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial precursor [Mus musculus]
GI:160358827 SwissProt Q9JJN4.2 520 RecName: Full=Succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial; AltName: Full=3-oxoacid CoA-transferase 2A; AltName: Full=Testis-specific succinyl-CoA:3-oxoacid CoA-transferase 1; Short=SCOT-t1; Flags: Precursor [Mus musculus]