Gene/Proteome Database (LMPD)

LMPD ID
LMP003119
Gene ID
51599
Species
Homo sapiens (Human)
Gene Name
lipolysis stimulated lipoprotein receptor
Gene Symbol
LSR
Synonyms
ILDR3; LISCH7
Alternate Names
lipolysis-stimulated lipoprotein receptor; LISCH protein; lipolysis-stimulated remnant; liver-specific bHLH-Zip transcription factor; immunoglobulin-like domain containing receptor 3
Chromosome
19
Map Location
19q13.12

Proteins

lipolysis-stimulated lipoprotein receptor isoform 1
Refseq ID NP_057009
Protein GI 45505163
UniProt ID Q86X29
mRNA ID NM_015925
Length 630
RefSeq Status VALIDATED
MQQDGLGVGTRNGSGKGRSVHPSWPWCAPRPLRYFGRDARARRAQTAAMALLAGGLSRGLGSHPAAAGRDAVVFVWLLLSTWCTAPARAIQVTVSNPYHVVILFQPVTLPCTYQMTSTPTQPIVIWKYKSFCRDRIADAFSPASVDNQLNAQLAAGNPGYNPYVECQDSVRTVRVVATKQGNAVTLGDYYQGRRITITGNADLTFDQTAWGDSGVYYCSVVSAQDLQGNNEAYAELIVLDWLFVVVVCLAAFLIFLLLGICWCQCCPHTCCCYVRCPCCPDKCCCPEALYAAGKAATSGVPSIYAPSTYAHLSPAKTPPPPAMIPMGPAYNGYPGGYPGDVDRSSSAGGQGSYVPLLRDTDSSVASEVRSGYRIQASQQDDSMRVLYYMEKELANFDPSRPGPPSGRVERAMSEVTSLHEDDWRSRPSRGPALTPIRDEEWGGHSPRSPRGWDQEPAREQAGGGWRARRPRARSVDALDDLTPPSTAESGSRSPTSNGGRSRAYMPPRSRSRDDLYDQDDSRDFPRSRDPHYDDFRSRERPPADPRSHHHRTRDPRDNGSRSGDLPYDGRLLEEAVRKKGSEERRRPHKEEEEEAYYPPAPPPYSETDSQASRERRLKKNLALSRESLVV
lipolysis-stimulated lipoprotein receptor isoform 2
Refseq ID NP_991403
Protein GI 45545424
UniProt ID Q86X29
mRNA ID NM_205834
Length 649
RefSeq Status VALIDATED
MQQDGLGVGTRNGSGKGRSVHPSWPWCAPRPLRYFGRDARARRAQTAAMALLAGGLSRGLGSHPAAAGRDAVVFVWLLLSTWCTAPARAIQVTVSNPYHVVILFQPVTLPCTYQMTSTPTQPIVIWKYKSFCRDRIADAFSPASVDNQLNAQLAAGNPGYNPYVECQDSVRTVRVVATKQGNAVTLGDYYQGRRITITGNADLTFDQTAWGDSGVYYCSVVSAQDLQGNNEAYAELIVLGRTSGVAELLPGFQAGPIEDWLFVVVVCLAAFLIFLLLGICWCQCCPHTCCCYVRCPCCPDKCCCPEALYAAGKAATSGVPSIYAPSTYAHLSPAKTPPPPAMIPMGPAYNGYPGGYPGDVDRSSSAGGQGSYVPLLRDTDSSVASEVRSGYRIQASQQDDSMRVLYYMEKELANFDPSRPGPPSGRVERAMSEVTSLHEDDWRSRPSRGPALTPIRDEEWGGHSPRSPRGWDQEPAREQAGGGWRARRPRARSVDALDDLTPPSTAESGSRSPTSNGGRSRAYMPPRSRSRDDLYDQDDSRDFPRSRDPHYDDFRSRERPPADPRSHHHRTRDPRDNGSRSGDLPYDGRLLEEAVRKKGSEERRRPHKEEEEEAYYPPAPPPYSETDSQASRERRLKKNLALSRESLVV
lipolysis-stimulated lipoprotein receptor isoform 3
Refseq ID NP_991404
Protein GI 45593136
UniProt ID Q86X29
mRNA ID NM_205835
Length 581
RefSeq Status VALIDATED
MQQDGLGVGTRNGSGKGRSVHPSWPWCAPRPLRYFGRDARARRAQTAAMALLAGGLSRGLGSHPAAAGRDAVVFVWLLLSTWCTAPARAIQVTVSNPYHVVILFQPVTLPCTYQMTSTPTQPIVIWKYKSFCRDRIADAFSPASVDNQLNAQLAAGNPGYNPYVECQDSVRTVRVVATKQGNAVTLGDYYQGRRITITGNADLTFDQTAWGDSGVYYCSVVSAQDLQGNNEAYAELIVLVYAAGKAATSGVPSIYAPSTYAHLSPAKTPPPPAMIPMGPAYNGYPGGYPGDVDRSSSAGGQGSYVPLLRDTDSSVASEVRSGYRIQASQQDDSMRVLYYMEKELANFDPSRPGPPSGRVERAMSEVTSLHEDDWRSRPSRGPALTPIRDEEWGGHSPRSPRGWDQEPAREQAGGGWRARRPRARSVDALDDLTPPSTAESGSRSPTSNGGRSRAYMPPRSRSRDDLYDQDDSRDFPRSRDPHYDDFRSRERPPADPRSHHHRTRDPRDNGSRSGDLPYDGRLLEEAVRKKGSEERRRPHKEEEEEAYYPPAPPPYSETDSQASRERRLKKNLALSRESLVV
lipolysis-stimulated lipoprotein receptor isoform 4
Refseq ID NP_001247418
Protein GI 386781455
UniProt ID Q86X29
mRNA ID NM_001260489
Length 629
RefSeq Status VALIDATED
MQQDGLGVGTRNGSGKGRSVHPSWPWCAPRPLRYFGRDARARRAQTAAMALLAGGLSRGLGSHPAAAGRDAVVFVWLLLSTWCTAPARAIQVTVSNPYHVVILFQPVTLPCTYQMTSTPTQPIVIWKYKSFCRDRIADAFSPASVDNQLNAQLAAGNPGYNPYVECQDSVRTVRVVATKQGNAVTLGDYYQGRRITITGNADLTFDQTAWGDSGVYYCSVVSAQDLQGNNEAYAELIVLDWLFVVVVCLAAFLIFLLLGICWCQCCPHTCCCYVRCPCCPDKCCCPEALYAAGKAATSGVPSIYAPSTYAHLSPAKTPPPPAMIPMGPAYNGYPGGYPGDVDRSSSAGGQGSYVPLLRDTDSSVASVRSGYRIQASQQDDSMRVLYYMEKELANFDPSRPGPPSGRVERAMSEVTSLHEDDWRSRPSRGPALTPIRDEEWGGHSPRSPRGWDQEPAREQAGGGWRARRPRARSVDALDDLTPPSTAESGSRSPTSNGGRSRAYMPPRSRSRDDLYDQDDSRDFPRSRDPHYDDFRSRERPPADPRSHHHRTRDPRDNGSRSGDLPYDGRLLEEAVRKKGSEERRRPHKEEEEEAYYPPAPPPYSETDSQASRERRLKKNLALSRESLVV
lipolysis-stimulated lipoprotein receptor isoform 5
Refseq ID NP_001247419
Protein GI 386781463
UniProt ID Q86X29
mRNA ID NM_001260490
Length 541
RefSeq Status VALIDATED
MQQDGLGVGTRNGSGKGRSVHPSWPWCAPRPLRYFGRDARARRAQTAAMALLAGGLSRGLGSHPAAAGRDAVVFVWLLLSTWCTAPARAIQVTVSNPYHVVILFQPVTLPCTYQMTSTPTQPIVIWKYKSFCRDRIADAFSPASVDNQLNAQLAAGNPGYNPYVECQDSVRTVRVVATKQGNAVTLGDYYQGRRITITGMYAAGKAATSGVPSIYAPSTYAHLSPAKTPPPPAMIPMGPAYNGYPGGYPGDVDRSSSAGGQGSYVPLLRDTDSSVASEVRSGYRIQASQQDDSMRVLYYMEKELANFDPSRPGPPSGRVERAMSEVTSLHEDDWRSRPSRGPALTPIRDEEWGGHSPRSPRGWDQEPAREQAGGGWRARRPRARSVDALDDLTPPSTAESGSRSPTSNGGRSRAYMPPRSRSRDDLYDQDDSRDFPRSRDPHYDDFRSRERPPADPRSHHHRTRDPRDNGSRSGDLPYDGRLLEEAVRKKGSEERRRPHKEEEEEAYYPPAPPPYSETDSQASRERRLKKNLALSRESLVV

Gene Information

Entrez Gene ID
51599
Gene Name
lipolysis stimulated lipoprotein receptor
Gene Symbol
LSR
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0042627 IEA:UniProtKB-KW C chylomicron
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0034362 IEA:UniProtKB-KW C low-density lipoprotein particle
GO:0005886 ISS:HGNC C plasma membrane
GO:0034361 IEA:UniProtKB-KW C very-low-density lipoprotein particle
GO:0009790 ISS:HGNC P embryo development
GO:0001889 ISS:HGNC P liver development

Domain Information

InterPro Annotations

Accession Description
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013783 Immunoglobulin-like fold
IPR008664 LISCH7

UniProt Annotations

Entry Information

Gene Name
lipolysis stimulated lipoprotein receptor
Protein Entry
LSR_HUMAN
UniProt ID
Q86X29
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q86X29-1; Sequence=Displayed; Name=2; IsoId=Q86X29-2; Sequence=VSP_019691, VSP_019693; Name=3; IsoId=Q86X29-3; Sequence=VSP_019692, VSP_019694; Name=4; IsoId=Q86X29-4; Sequence=VSP_019692; Name=5; IsoId=Q86X29-5; Sequence=VSP_046797; Note=No experimental confirmation available.; Name=6; IsoId=Q86X29-6; Sequence=VSP_057210, VSP_057211; Note=No experimental confirmation available;
Caution In contrast to the rodent orthologous protein, it is longer in N-terminus and no signal sequence is detected by any prediction method.
Function Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity).
Sequence Caution Sequence=AAB51178.1; Type=Erroneous gene model prediction; Evidence= ; Sequence=AAB58317.1; Type=Erroneous gene model prediction; Evidence= ; Sequence=AAH04381.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ;
Similarity Belongs to the immunoglobulin superfamily. LISCH7 family.
Similarity Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Subcellular Location Cell membrane ; Single-pass membrane protein .
Subunit Homotrimer or homotetramer.

Identical and Related Proteins

Unique RefSeq proteins for LMP003119 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
45505163 RefSeq NP_057009 630 lipolysis-stimulated lipoprotein receptor isoform 1
45545424 RefSeq NP_991403 649 lipolysis-stimulated lipoprotein receptor isoform 2
45593136 RefSeq NP_991404 581 lipolysis-stimulated lipoprotein receptor isoform 3
386781455 RefSeq NP_001247418 629 lipolysis-stimulated lipoprotein receptor isoform 4
386781463 RefSeq NP_001247419 541 lipolysis-stimulated lipoprotein receptor isoform 5

Identical Sequences to LMP003119 proteins

Reference Database Accession Length Protein Name
GI:45505163 EMBL CCF76948.1 630 unnamed protein product [Homo sapiens]
GI:45545424 EMBL CCF76949.1 649 unnamed protein product [Homo sapiens]
GI:45593136 EMBL CCF76950.1 581 unnamed protein product [Homo sapiens]
GI:45505163 GenBank AAR67379.1 630 Sequence 10 from patent US 6635431
GI:45593136 GenBank AAR67380.1 581 Sequence 12 from patent US 6635431
GI:45545424 GenBank ABL20737.1 649 Sequence 14 from patent US 7125667
GI:45505163 GenBank ABL20738.1 630 Sequence 16 from patent US 7125667
GI:45593136 GenBank ABL20739.1 581 Sequence 18 from patent US 7125667
GI:45545424 GenBank ABX97974.1 649 Sequence 8 from patent US 7291709
GI:45505163 GenBank ABX97975.1 630 Sequence 10 from patent US 7291709
GI:45593136 GenBank ABX97976.1 581 Sequence 12 from patent US 7291709
GI:45545424 GenBank ACM96519.1 649 Sequence 3 from patent US 7470669
GI:45505163 GenBank ACM96520.1 630 Sequence 5 from patent US 7470669
GI:45593136 GenBank ACM96521.1 581 Sequence 7 from patent US 7470669
GI:45545424 GenBank AED79454.1 649 Sequence 8 from patent US 7919091
GI:45505163 GenBank AED79455.1 630 Sequence 10 from patent US 7919091
GI:45593136 GenBank AED79456.1 581 Sequence 12 from patent US 7919091
GI:45545424 GenBank AIC51531.1 649 LSR, partial [synthetic construct]

Related Sequences to LMP003119 proteins

Reference Database Accession Length Protein Name
GI:45545424 DBBJ BAI45831.1 650 lipolysis stimulated lipoprotein receptor, partial [synthetic construct]
GI:386781455 EMBL CCF76948.1 630 unnamed protein product [Homo sapiens]
GI:386781463 EMBL CCF76950.1 581 unnamed protein product [Homo sapiens]
GI:45505163 GenBank AAN98475.1 649 Sequence 14 from patent US 6479238
GI:386781455 GenBank AAN98476.1 630 Sequence 16 from patent US 6479238
GI:45505163 GenBank AAR67378.1 649 Sequence 8 from patent US 6635431
GI:386781455 GenBank AAR67379.1 630 Sequence 10 from patent US 6635431
GI:386781455 GenBank ABL20738.1 630 Sequence 16 from patent US 7125667
GI:386781463 GenBank ABL20739.1 581 Sequence 18 from patent US 7125667
GI:386781455 GenBank ABX97975.1 630 Sequence 10 from patent US 7291709
GI:386781463 GenBank ABX97976.1 581 Sequence 12 from patent US 7291709
GI:45593136 GenBank ACM96520.1 630 Sequence 5 from patent US 7470669
GI:386781455 GenBank AED79455.1 630 Sequence 10 from patent US 7919091
GI:45593136 GenBank AED79455.1 630 Sequence 10 from patent US 7919091
GI:386781463 GenBank AED79456.1 581 Sequence 12 from patent US 7919091
GI:45505163 GenBank AIC51531.1 649 LSR, partial [synthetic construct]
GI:45505163 RefSeq NP_991403.1 649 lipolysis-stimulated lipoprotein receptor isoform 2 [Homo sapiens]
GI:386781463 RefSeq NP_991404.1 581 lipolysis-stimulated lipoprotein receptor isoform 3 [Homo sapiens]
GI:45545424 RefSeq NP_001243519.1 650 lipolysis-stimulated lipoprotein receptor [Pan troglodytes]
GI:45505163 RefSeq NP_001247418.1 629 lipolysis-stimulated lipoprotein receptor isoform 4 [Homo sapiens]
GI:45593136 RefSeq XP_003816149.1 686 PREDICTED: lipolysis-stimulated lipoprotein receptor isoform X5 [Pan paniscus]
GI:45545424 RefSeq XP_003816150.1 754 PREDICTED: lipolysis-stimulated lipoprotein receptor isoform X1 [Pan paniscus]
GI:45505163 RefSeq XP_004060553.1 631 PREDICTED: lipolysis-stimulated lipoprotein receptor isoform 1 [Gorilla gorilla gorilla]
GI:45593136 RefSeq XP_004060554.1 582 PREDICTED: lipolysis-stimulated lipoprotein receptor isoform 2 [Gorilla gorilla gorilla]
GI:45545424 RefSeq XP_004060555.1 650 PREDICTED: lipolysis-stimulated lipoprotein receptor isoform 3 [Gorilla gorilla gorilla]
GI:386781463 RefSeq XP_004060556.1 542 PREDICTED: lipolysis-stimulated lipoprotein receptor isoform 4 [Gorilla gorilla gorilla]
GI:45545424 RefSeq XP_005259037.1 648 PREDICTED: lipolysis-stimulated lipoprotein receptor isoform X1 [Homo sapiens]
GI:45593136 RefSeq XP_005259039.1 580 PREDICTED: lipolysis-stimulated lipoprotein receptor isoform X3 [Homo sapiens]
GI:45545424 RefSeq XP_008967452.1 753 PREDICTED: lipolysis-stimulated lipoprotein receptor isoform X2 [Pan paniscus]
GI:45593136 RefSeq XP_008967454.1 685 PREDICTED: lipolysis-stimulated lipoprotein receptor isoform X6 [Pan paniscus]