Gene/Proteome Database (LMPD)

LMPD ID
LMP003138
Gene ID
122618
Species
Homo sapiens (Human)
Gene Name
phospholipase D family, member 4
Gene Symbol
PLD4
Synonyms
C14orf175
Alternate Names
phospholipase D4; PLD 4; choline phosphatase 4; phosphatidylcholine-hydrolyzing phospholipase D4
Chromosome
14
Map Location
14q32.33
EC Number
3.1.4.4

Proteins

phospholipase D4
Refseq ID NP_620145
Protein GI 94681038
UniProt ID Q96BZ4
mRNA ID NM_138790
Length 506
RefSeq Status VALIDATED
MLKPLWKAAVAPTWPCSMPPRRPWDREAGTLQVLGALAVLWLGSVALICLLWQVPRPPTWGQVQPKDVPRSWEHGSSPAWEPLEAEARQQRDSCQLVLVESIPQDLPSAAGSPSAQPLGQAWLQLLDTAQESVHVASYYWSLTGPDIGVNDSSSQLGEALLQKLQQLLGRNISLAVATSSPTLARTSTDLQVLAARGAHVRQVPMGRLTRGVLHSKFWVVDGRHIYMGSANMDWRSLTQVKELGAVIYNCSHLAQDLEKTFQTYWVLGVPKAVLPKTWPQNFSSHFNRFQPFHGLFDGVPTTAYFSASPPALCPQGRTRDLEALLAVMGSAQEFIYASVMEYFPTTRFSHPPRYWPVLDNALRAAAFGKGVRVRLLVGCGLNTDPTMFPYLRSLQALSNPAANVSVDVKVFIVPVGNHSNIPFSRVNHSKFMVTEKAAYIGTSNWSEDYFSSTAGVGLVVTQSPGAQPAGATVQEQLRQLFERDWSSRYAVGLDGQAPGQDCVWQG

Gene Information

Entrez Gene ID
122618
Gene Name
phospholipase D family, member 4
Gene Symbol
PLD4
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005634 IEA:Ensembl C nucleus
GO:0045335 IEA:Ensembl C phagocytic vesicle
GO:0032588 IEA:Ensembl C trans-Golgi network membrane
GO:0070290 IEA:UniProtKB-EC F N-acylphosphatidylethanolamine-specific phospholipase D activity
GO:0004435 TAS:Reactome F phosphatidylinositol phospholipase C activity
GO:0004630 IEA:UniProtKB-EC F phospholipase D activity
GO:0046474 TAS:Reactome P glycerophospholipid biosynthetic process
GO:0002244 IEA:Ensembl P hematopoietic progenitor cell differentiation
GO:0043647 TAS:Reactome P inositol phosphate metabolic process
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0006909 IEA:Ensembl P phagocytosis
GO:0006655 TAS:Reactome P phosphatidylglycerol biosynthetic process
GO:0006644 TAS:Reactome P phospholipid metabolic process
GO:0044281 TAS:Reactome P small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00565 Ether lipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_160158 Role of phospholipids in phagocytosis
REACT_150312 Synthesis of IP3 and IP4 in the cytosol
REACT_121280 Synthesis of PG

Domain Information

InterPro Annotations

Accession Description
IPR001736 Phospholipase D/Transphosphatidylase

UniProt Annotations

Entry Information

Gene Name
phospholipase D family, member 4
Protein Entry
PLD4_HUMAN
UniProt ID
Q96BZ4
Species
Human

Comments

Comment Type Description
Catalytic Activity A phosphatidylcholine + H(2)O = choline + a phosphatidate.
Sequence Caution Sequence=AAQ89202.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the phospholipase D family.
Similarity Contains 2 PLD phosphodiesterase domains.
Subcellular Location Membrane ; Single-pass membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP003138 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
94681038 RefSeq NP_620145 506 phospholipase D4

Identical Sequences to LMP003138 proteins

Reference Database Accession Length Protein Name
GI:94681038 GenBank AAH15003.2 506 Phospholipase D family, member 4 [Homo sapiens]
GI:94681038 GenBank ABJ31083.1 506 Sequence 15 from patent US 7098015
GI:94681038 SwissProt Q96BZ4.2 506 RecName: Full=Phospholipase D4; Short=PLD 4; AltName: Full=Choline phosphatase 4; AltName: Full=Phosphatidylcholine-hydrolyzing phospholipase D4 [Homo sapiens]

Related Sequences to LMP003138 proteins

Reference Database Accession Length Protein Name
GI:94681038 DBBJ BAG58319.1 506 unnamed protein product [Homo sapiens]
GI:94681038 DBBJ BAG58918.1 513 unnamed protein product [Homo sapiens]
GI:94681038 GenBank EAW81887.1 506 phospholipase D family, member 4 [Homo sapiens]
GI:94681038 RefSeq XP_003807044.1 515 PREDICTED: phospholipase D4 [Pan paniscus]
GI:94681038 RefSeq XP_004055836.1 515 PREDICTED: phospholipase D4 isoform 1 [Gorilla gorilla gorilla]
GI:94681038 RefSeq XP_006720087.1 513 PREDICTED: phospholipase D4 isoform X1 [Homo sapiens]