Gene/Proteome Database (LMPD)

LMPD ID
LMP003154
Gene ID
80142
Species
Homo sapiens (Human)
Gene Name
prostaglandin E synthase 2
Gene Symbol
PTGES2
Synonyms
C9orf15; GBF-1; GBF1; PGES2; mPGES-2
Chromosome
9
Map Location
9q34.11
Summary
The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. [provided by RefSeq, Jun 2009]
Orthologs
View orthologs and multiple alignments for PTGES2

Proteins

prostaglandin E synthase 2 isoform 1
Refseq ID NP_079348
Protein GI 13376617
UniProt ID Q9H7Z7
mRNA ID NM_025072
Length 377
RefSeq Status REVIEWED
MDPAARVVRALWPGGCALAWRLGGRPQPLLPTQSRAGFAGAAGGPSPVAAARKGSPRLLGAAALALGGALGLYHTARWHLRAQDLHAERSAAQLSLSSRLQLTLYQYKTCPFCSKVRAFLDFHALPYQVVEVNPVRRAEIKFSSYRKVPILVAQEGESSQQLNDSSVIISALKTYLVSGQPLEEIITYYPAMKAVNEQGKEVTEFGNKYWLMLNEKEAQQVYGGKEARTEEMKWRQWADDWLVHLISPNVYRTPTEALASFDYIVREGKFGAVEGAVAKYMGAAAMYLISKRLKSRHRLQDNVREDLYEAADKWVAAVGKDRPFMGGQKPNLADLAVYGVLRVMEGLDAFDDLMQHTHIQPWYLRVERAITEASPAH
prostaglandin E synthase 2 isoform 2
Refseq ID NP_001243264
Protein GI 373251223
UniProt ID Q9H7Z7
mRNA ID NM_001256335
Length 186
RefSeq Status REVIEWED
MKAVNEQGKEVTEFGNKYWLMLNEKEAQQVYGGKEARTEEMKWRQWADDWLVHLISPNVYRTPTEALASFDYIVREGKFGAVEGAVAKYMGAAAMYLISKRLKSRHRLQDNVREDLYEAADKWVAAVGKDRPFMGGQKPNLADLAVYGVLRVMEGLDAFDDLMQHTHIQPWYLRVERAITEASPAH
prostaglandin E synthase 2 isoform 2
Refseq ID NP_945176
Protein GI 40068469
UniProt ID Q9H7Z7
mRNA ID NM_198938
Length 186
RefSeq Status REVIEWED
Protein sequence is identical to GI:373251223 (mRNA isoform)
mat_peptide: 88..377 product: Prostaglandin E synthase 2 truncated form. {ECO:0000250} experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9H7Z7.1) calculated_mol_wt: 33108 peptide sequence: ERSAAQLSLSSRLQLTLYQYKTCPFCSKVRAFLDFHALPYQVVEVNPVRRAEIKFSSYRKVPILVAQEGESSQQLNDSSVIISALKTYLVSGQPLEEIITYYPAMKAVNEQGKEVTEFGNKYWLMLNEKEAQQVYGGKEARTEEMKWRQWADDWLVHLISPNVYRTPTEALASFDYIVREGKFGAVEGAVAKYMGAAAMYLISKRLKSRHRLQDNVREDLYEAADKWVAAVGKDRPFMGGQKPNLADLAVYGVLRVMEGLDAFDDLMQHTHIQPWYLRVERAITEASPAH

Gene Information

Entrez Gene ID
80142
Gene Name
prostaglandin E synthase 2
Gene Symbol
PTGES2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IEA:Ensembl C cytosol
GO:0005739 IEA:Ensembl C mitochondrion
GO:0005634 IEA:Ensembl C nucleus
GO:0003677 IEA:Ensembl F DNA binding
GO:0045893 IEA:Ensembl P positive regulation of transcription, DNA-templated
GO:0046903 IEA:Ensembl P secretion

KEGG Pathway Links

KEGG Pathway ID Description
hsa00590 Arachidonic acid metabolism
hsa01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR004046 Glutathione S-transferase, C-terminal
IPR010987 Glutathione S-transferase, C-terminal-like

UniProt Annotations

Entry Information

Gene Name
prostaglandin E synthase 2
Protein Entry
PGES2_HUMAN
UniProt ID
Q9H7Z7
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP003154 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13376617 RefSeq NP_079348 377 prostaglandin E synthase 2 isoform 1
373251223 RefSeq NP_001243264 186 prostaglandin E synthase 2 isoform 2

Identical Sequences to LMP003154 proteins

Reference Database Accession Length Protein Name
GI:373251223 GenBank EAW87743.1 186 prostaglandin E synthase 2, isoform CRA_c [Homo sapiens]
GI:373251223 GenBank EAW87744.1 186 prostaglandin E synthase 2, isoform CRA_c [Homo sapiens]
GI:373251223 GenBank EAW87745.1 186 prostaglandin E synthase 2, isoform CRA_c [Homo sapiens]
GI:13376617 GenBank JAA05423.1 377 prostaglandin E synthase 2 [Pan troglodytes]
GI:13376617 GenBank JAA13203.1 377 prostaglandin E synthase 2 [Pan troglodytes]
GI:13376617 GenBank JAA24278.1 377 prostaglandin E synthase 2 [Pan troglodytes]
GI:13376617 GenBank JAA34990.1 377 prostaglandin E synthase 2 [Pan troglodytes]
GI:13376617 GenBank AIC62817.1 377 PTGES2, partial [synthetic construct]
GI:373251223 RefSeq NP_945176.1 186 prostaglandin E synthase 2 isoform 2 [Homo sapiens]
GI:13376617 RefSeq NP_001233456.1 377 prostaglandin E synthase 2 [Pan troglodytes]
GI:373251223 RefSeq XP_005252296.1 186 PREDICTED: prostaglandin E synthase 2 isoform X1 [Homo sapiens]

Related Sequences to LMP003154 proteins

Reference Database Accession Length Protein Name
GI:13376617 DBBJ BAD97240.1 377 prostaglandin E synthase 2 isoform 1 variant, partial [Homo sapiens]
GI:13376617 DBBJ BAG51854.1 377 unnamed protein product [Homo sapiens]
GI:373251223 DBBJ BAK64037.1 377 prostaglandin E synthase 2 [Pan troglodytes]
GI:373251223 EMBL CAL37443.1 377 hypothetical protein, partial [synthetic construct]
GI:13376617 GenBank AAH09456.1 376 Unknown (protein for IMAGE:3536456), partial [Homo sapiens]
GI:373251223 GenBank AAH09456.1 376 Unknown (protein for IMAGE:3536456), partial [Homo sapiens]
GI:13376617 GenBank EAW87741.1 396 prostaglandin E synthase 2, isoform CRA_a [Homo sapiens]
GI:13376617 GenBank EAW87742.1 379 prostaglandin E synthase 2, isoform CRA_b [Homo sapiens]
GI:373251223 GenBank EAW87746.1 377 prostaglandin E synthase 2, isoform CRA_d [Homo sapiens]
GI:373251223 RefSeq NP_079348.1 377 prostaglandin E synthase 2 isoform 1 [Homo sapiens]
GI:373251223 RefSeq NP_001233456.1 377 prostaglandin E synthase 2 [Pan troglodytes]
GI:13376617 RefSeq XP_004048721.1 377 PREDICTED: prostaglandin E synthase 2 isoform 1 [Gorilla gorilla gorilla]