Gene/Proteome Database (LMPD)

LMPD ID
LMP003170
Gene ID
67909
Species
Mus musculus (Mouse)
Gene Name
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5
Gene Symbol
Galntl5
Synonyms
1700021B12Rik; Galnt15
Alternate Names
inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5; galNAc-T15; pp-GaNTase 15; polypeptide GalNAc transferase 15; protein-UDP acetylgalactosaminyltransferase 15; polypeptide N-acetylgalactosaminyltransferase-like 5; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 15; putative polypeptide N-acetylgalactosaminyltransferase-like protein 5; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15
Chromosome
5
Map Location
5 A3|5

Proteins

inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5
Refseq ID NP_080725
Protein GI 254553456
UniProt ID Q9D4M9
mRNA ID NM_026449
Length 431
RefSeq Status VALIDATED
MKSVIIQGLFCGFLAIGLWASMLLLFLHLEQEDMLENEKEELLKKRSLGKNAHQQTRHSEDVTHDEVNFSDPELIQGLRRYGLNAIMSRRLGIEREVPDSRDKICQQKHYPFNLPTASIIICFYNEEFNTLLRAVSSVVNLSPQHLLEEIILVDDMSEFDDLKDKLDYYLEIFRGKVKLIRNKKREGLIRSKMIGASRASGDILVFLDSHCEVNRVWLEPLLHAIAKDHKMVVCPIIDVINELTLDYMAAPIVRGAFDWNLNLRWDNVFAYELDGPEGPSTPIRSPAMTGGIFAINRHYFNELGQYDNGMDICGGENVELSLRIWMCGGQLFILPCSRVGYNSKALSQHRRANQSALSRNLLRVVHVWLDEYKGNFFLQRPSLTYVSCGNISERVELRKRLGCKSFQWYLDNIFPELEPFNTERKRKKNRF

Gene Information

Entrez Gene ID
67909
Gene Name
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5
Gene Symbol
Galntl5
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005768 IEA:UniProtKB-KW C endosome
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0007286 IMP:UniProtKB P spermatid development

KEGG Pathway Links

KEGG Pathway ID Description
mmu01100 Metabolic pathways
ko00512 Mucin type O-Glycan biosynthesis
mmu00512 Mucin type O-Glycan biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001173 Glycosyltransferase 2-like
IPR029044 Nucleotide-diphospho-sugar transferases

UniProt Annotations

Entry Information

Gene Name
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5
Protein Entry
GLTL5_MOUSE
UniProt ID
Q9D4M9
Species
Mouse

Comments

Comment Type Description
Caution In contrast to other members of the family, lacks the C- terminal ricin B-type lectin domain that contributes to the glycopeptide specificity, and lacks the conserved His residue in position 341. No glycosyltransferase activity has been detected in an in vitro assay (PubMed:24398516). {ECO:0000305|PubMed:24398516}.
Cofactor Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
Disruption Phenotype Heterozygous mice show male infertility because of immotile sperm: glycolytic enzymes required for sperm motility are decreased, their protein loading into acrosomes disrupted, and aberrant localization of the ubiquitin-proteasome system is observed. Females show normal fertility. {ECO:0000269|PubMed:24398516}.
Domain There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding. {ECO:0000250}.
Function Probable inactive glycosyltransferase required during spermatid development. May participate to protein loading into the acrosomes and accumulation of ubiquitin-proteasome systems around the head-tail coupling apparatus region. {ECO:0000269|PubMed:24398516}.
Sequence Caution Sequence=AAH49554.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Similarity Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily. {ECO:0000305}.
Subcellular Location Late endosome membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=Localizes to the juxtanuclear region, possibly the late endosome. Not localized in the Golgi apparatus in round spermatids (PubMed:24398516). {ECO:0000269|PubMed:24398516}.
Tissue Specificity Expressed in testis. Mainly expressed in the round and elongated spermatids during spermiogenesis, not in the outermost cells of the seminiferous tubules, which contain spermatogonia and somatic Sertoli cells. Present in the juxtanuclear space in the round spermatids, not in the acrosomal vesicles. In the elongating spermatids, localizes strongly in the acroplaxome, the region between the developing acrosome and nucleus. During differentiation, also weakly detected in the transient manchette containing microtubules. In epididymal spermatozoa, weakly detected in the midpiece, but concentrates mainly in the neck region around the head-tail coupling apparatus (at protein level). {ECO:0000269|PubMed:24398516}.
Web Resource Name=Functional Glycomics Gateway - GTase; Note=Putative polypeptide N-acetylgalactosaminyltransferase-like protein 5; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_523";

Identical and Related Proteins

Unique RefSeq proteins for LMP003170 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
254553456 RefSeq NP_080725 431 inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5

Identical Sequences to LMP003170 proteins

Reference Database Accession Length Protein Name
GI:254553456 GenBank EDL03081.1 431 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5, isoform CRA_b [Mus musculus]
GI:254553456 GenBank AAI45758.1 431 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5 [Mus musculus]
GI:254553456 SwissProt Q9D4M9.2 431 RecName: Full=Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5; AltName: Full=Polypeptide GalNAc transferase 15; Short=GalNAc-T15; Short=pp-GaNTase 15; AltName: Full=Protein-UDP acetylgalactosaminyltransferase 15; AltName: Full=UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 15 [Mus musculus]

Related Sequences to LMP003170 proteins

Reference Database Accession Length Protein Name
GI:254553456 DBBJ BAB24147.1 424 unnamed protein product, partial [Mus musculus]
GI:254553456 DBBJ BAB30220.1 431 unnamed protein product [Mus musculus]
GI:254553456 GenBank AAH49554.1 434 Galntl5 protein, partial [Mus musculus]
GI:254553456 GenBank AAI00448.1 447 Galntl5 protein, partial [Mus musculus]
GI:254553456 GenBank EDL03080.1 490 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5, isoform CRA_a, partial [Mus musculus]
GI:254553456 RefSeq NP_001020319.1 443 inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5 [Rattus norvegicus]