Gene/Proteome Database (LMPD)
LMPD ID
LMP003177
Gene ID
Species
Homo sapiens (Human)
Gene Name
ceramide synthase 2
Gene Symbol
Synonyms
L3; LASS2; SP260; TMSG1
Alternate Names
ceramide synthase 2; LAG1 longevity assurance 2; LAG1 homolog, ceramide synthase 2; tumor metastasis-suppressor gene 1 protein; longevity assurance (LAG1, S. cerevisiae) homolog 2
Chromosome
1
Map Location
1q21.3
Summary
This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
ceramide synthase 2 | |
---|---|
Refseq ID | NP_071358 |
Protein GI | 31077094 |
UniProt ID | Q96G23 |
mRNA ID | NM_022075 |
Length | 380 |
RefSeq Status | REVIEWED |
MLQTLYDYFWWERLWLPVNLTWADLEDRDGRVYAKASDLYITLPLALLFLIVRYFFELYVATPLAALLNIKEKTRLRAPPNATLEHFYLTSGKQPKQVEVELLSRQSGLSGRQVERWFRRRRNQDRPSLLKKFREASWRFTFYLIAFIAGMAVIVDKPWFYDMKKVWEGYPIQSTIPSQYWYYMIELSFYWSLLFSIASDVKRKDFKEQIIHHVATIILISFSWFANYIRAGTLIMALHDSSDYLLESAKMFNYAGWKNTCNNIFIVFAIVFIITRLVILPFWILHCTLVYPLELYPAFFGYYFFNSMMGVLQLLHIFWAYLILRMAHKFITGKLVEDERSDREETESSEGEEAAAGGGAKSRPLANGHPILNNNHRKND |
Gene Information
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0005783 | IDA:HPA | C | endoplasmic reticulum |
GO:0005789 | TAS:Reactome | C | endoplasmic reticulum membrane |
GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
GO:0016020 | IDA:UniProtKB | C | membrane |
GO:0031965 | IDA:HPA | C | nuclear membrane |
GO:0003677 | IEA:UniProtKB-KW | F | DNA binding |
GO:0050291 | IEA:Ensembl | F | sphingosine N-acyltransferase activity |
GO:0046513 | IEA:Ensembl | P | ceramide biosynthetic process |
GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
GO:0030148 | TAS:Reactome | P | sphingolipid biosynthetic process |
GO:0006665 | TAS:Reactome | P | sphingolipid metabolic process |
REACTOME Pathway Links
REACTOME Pathway ID | Description |
---|---|
REACT_115810 | Sphingolipid de novo biosynthesis |
Domain Information
UniProt Annotations
Entry Information
Comments
Comment Type | Description |
---|---|
Function | Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis. |
Interaction | P07306:ASGR1; NbExp=3; IntAct=EBI-1057080, EBI-1172335; P07307:ASGR2; NbExp=3; IntAct=EBI-1057080, EBI-1172636; P27449:ATP6V0C; NbExp=3; IntAct=EBI-1057080, EBI-721179; P07900:HSP90AA1; NbExp=2; IntAct=EBI-1057080, EBI-296047; O15245:SLC22A1; NbExp=3; IntAct=EBI-1057080, EBI-1172714; |
Sequence Caution | Sequence=BAA91505.1; Type=Erroneous initiation; Evidence= ; |
Similarity | Contains 1 TLC (TRAM/LAG1/CLN8) domain. |
Similarity | Contains 1 homeobox DNA-binding domain. |
Subcellular Location | Nucleus membrane {ECO |
Subunit | Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1. Interacts with ELOV1, HSD17B12 and TECR. |
Tissue Specificity | Expressed in kidney, liver, brain, heart, placenta and lung. |
Identical and Related Proteins
Unique RefSeq proteins for LMP003177 (as displayed in Record Overview)
Identical Sequences to LMP003177 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:31077094 | GenBank | AIC51308.1 | 380 | CERS2, partial [synthetic construct] |
GI:31077094 | GenBank | AIC63389.1 | 380 | CERS2, partial [synthetic construct] |
GI:31077094 | RefSeq | XP_008968699.1 | 380 | PREDICTED: ceramide synthase 2 isoform X2 [Pan paniscus] |
GI:31077094 | RefSeq | XP_008968700.1 | 380 | PREDICTED: ceramide synthase 2 isoform X2 [Pan paniscus] |
GI:31077094 | RefSeq | XP_008968701.1 | 380 | PREDICTED: ceramide synthase 2 isoform X2 [Pan paniscus] |
GI:31077094 | RefSeq | XP_009429155.1 | 380 | PREDICTED: ceramide synthase 2 isoform X2 [Pan troglodytes] |
Related Sequences to LMP003177 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:31077094 | DBBJ | BAF83678.1 | 380 | unnamed protein product [Homo sapiens] |
GI:31077094 | RefSeq | XP_008017479.1 | 380 | PREDICTED: ceramide synthase 2 [Chlorocebus sabaeus] |
GI:31077094 | RefSeq | XP_008017480.1 | 380 | PREDICTED: ceramide synthase 2 [Chlorocebus sabaeus] |
GI:31077094 | RefSeq | XP_008968698.1 | 406 | PREDICTED: ceramide synthase 2 isoform X1 [Pan paniscus] |
GI:31077094 | RefSeq | XP_009429139.1 | 406 | PREDICTED: ceramide synthase 2 isoform X1 [Pan troglodytes] |
GI:31077094 | RefSeq | XP_010385539.1 | 380 | PREDICTED: ceramide synthase 2 [Rhinopithecus roxellana] |