Gene/Proteome Database (LMPD)

LMPD ID
LMP003177
Gene ID
29956
Species
Homo sapiens (Human)
Gene Name
ceramide synthase 2
Gene Symbol
CERS2
Synonyms
L3; LASS2; SP260; TMSG1
Alternate Names
ceramide synthase 2; LAG1 longevity assurance 2; LAG1 homolog, ceramide synthase 2; tumor metastasis-suppressor gene 1 protein; longevity assurance (LAG1, S. cerevisiae) homolog 2
Chromosome
1
Map Location
1q21.3
Summary
This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for CERS2

Proteins

ceramide synthase 2
Refseq ID NP_071358
Protein GI 31077094
UniProt ID Q96G23
mRNA ID NM_022075
Length 380
RefSeq Status REVIEWED
MLQTLYDYFWWERLWLPVNLTWADLEDRDGRVYAKASDLYITLPLALLFLIVRYFFELYVATPLAALLNIKEKTRLRAPPNATLEHFYLTSGKQPKQVEVELLSRQSGLSGRQVERWFRRRRNQDRPSLLKKFREASWRFTFYLIAFIAGMAVIVDKPWFYDMKKVWEGYPIQSTIPSQYWYYMIELSFYWSLLFSIASDVKRKDFKEQIIHHVATIILISFSWFANYIRAGTLIMALHDSSDYLLESAKMFNYAGWKNTCNNIFIVFAIVFIITRLVILPFWILHCTLVYPLELYPAFFGYYFFNSMMGVLQLLHIFWAYLILRMAHKFITGKLVEDERSDREETESSEGEEAAAGGGAKSRPLANGHPILNNNHRKND
ceramide synthase 2
Refseq ID NP_859530
Protein GI 32455256
UniProt ID Q96G23
mRNA ID NM_181746
Length 380
RefSeq Status REVIEWED
Protein sequence is identical to GI:31077094 (mRNA isoform)

Gene Information

Entrez Gene ID
29956
Gene Name
ceramide synthase 2
Gene Symbol
CERS2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:HPA C endoplasmic reticulum
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016020 IDA:UniProtKB C membrane
GO:0031965 IDA:HPA C nuclear membrane
GO:0003677 IEA:UniProtKB-KW F DNA binding
GO:0050291 IEA:Ensembl F sphingosine N-acyltransferase activity
GO:0046513 IEA:Ensembl P ceramide biosynthetic process
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0030148 TAS:Reactome P sphingolipid biosynthetic process
GO:0006665 TAS:Reactome P sphingolipid metabolic process

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_115810 Sphingolipid de novo biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR016439 Longevity assurance, LAG1/LAC1
IPR006634 TRAM/LAG1/CLN8 homology domain

UniProt Annotations

Entry Information

Gene Name
ceramide synthase 2
Protein Entry
CERS2_HUMAN
UniProt ID
Q96G23
Species
Human

Comments

Comment Type Description
Function Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis.
Interaction P07306:ASGR1; NbExp=3; IntAct=EBI-1057080, EBI-1172335; P07307:ASGR2; NbExp=3; IntAct=EBI-1057080, EBI-1172636; P27449:ATP6V0C; NbExp=3; IntAct=EBI-1057080, EBI-721179; P07900:HSP90AA1; NbExp=2; IntAct=EBI-1057080, EBI-296047; O15245:SLC22A1; NbExp=3; IntAct=EBI-1057080, EBI-1172714;
Sequence Caution Sequence=BAA91505.1; Type=Erroneous initiation; Evidence= ;
Similarity Contains 1 homeobox DNA-binding domain.
Similarity Contains 1 TLC (TRAM/LAG1/CLN8) domain.
Subcellular Location Nucleus membrane {ECO
Subunit Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1. Interacts with ELOV1, HSD17B12 and TECR.
Tissue Specificity Expressed in kidney, liver, brain, heart, placenta and lung.

Identical and Related Proteins

Unique RefSeq proteins for LMP003177 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31077094 RefSeq NP_071358 380 ceramide synthase 2

Identical Sequences to LMP003177 proteins

Reference Database Accession Length Protein Name
GI:31077094 GenBank AIC51308.1 380 CERS2, partial [synthetic construct]
GI:31077094 GenBank AIC63389.1 380 CERS2, partial [synthetic construct]
GI:31077094 RefSeq XP_008968699.1 380 PREDICTED: ceramide synthase 2 isoform X2 [Pan paniscus]
GI:31077094 RefSeq XP_008968700.1 380 PREDICTED: ceramide synthase 2 isoform X2 [Pan paniscus]
GI:31077094 RefSeq XP_008968701.1 380 PREDICTED: ceramide synthase 2 isoform X2 [Pan paniscus]
GI:31077094 RefSeq XP_009429155.1 380 PREDICTED: ceramide synthase 2 isoform X2 [Pan troglodytes]

Related Sequences to LMP003177 proteins

Reference Database Accession Length Protein Name
GI:31077094 DBBJ BAF83678.1 380 unnamed protein product [Homo sapiens]
GI:31077094 RefSeq XP_008017479.1 380 PREDICTED: ceramide synthase 2 [Chlorocebus sabaeus]
GI:31077094 RefSeq XP_008017480.1 380 PREDICTED: ceramide synthase 2 [Chlorocebus sabaeus]
GI:31077094 RefSeq XP_008968698.1 406 PREDICTED: ceramide synthase 2 isoform X1 [Pan paniscus]
GI:31077094 RefSeq XP_009429139.1 406 PREDICTED: ceramide synthase 2 isoform X1 [Pan troglodytes]
GI:31077094 RefSeq XP_010385539.1 380 PREDICTED: ceramide synthase 2 [Rhinopithecus roxellana]