Gene/Proteome Database (LMPD)

LMPD ID
LMP003184
Gene ID
54857
Species
Homo sapiens (Human)
Gene Name
glycerophosphodiester phosphodiesterase domain containing 2
Gene Symbol
GDPD2
Synonyms
GDE3; OBDPF
Alternate Names
glycerophosphoinositol inositolphosphodiesterase GDPD2; glycerophosphodiester phosphodiesterase 3; osteoblast differentiation promoting factor; glycerophosphodiester phosphodiesterase domain-containing protein 2
Chromosome
X
Map Location
Xq13.1
EC Number
3.1.4.43
Summary
This gene encodes a member of the glycerophosphodiester phosphodiesterase enzyme family. The encoded protein hydrolyzes glycerophosphoinositol to produce inositol 1-phosphate and glycerol. This protein may have a role in osteoblast differentiation and growth. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]
Orthologs
View orthologs and multiple alignments for GDPD2

Proteins

glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform 1
Refseq ID NP_001164663
Protein GI 284055242
UniProt ID Q9HCC8
mRNA ID NM_001171192
Length 590
RefSeq Status REVIEWED
MAESPGCCSVWARCLHCLYSCHWRKCPRERMQTSKCDCIWFGLLFLTFLLSLSWLYIGLVLLNDLHNFNEFLFRRWGHWMDWSLAFLLVISLLVTYASLLLVLALLLRLCRQPLHLHSLHKVLLLLIMLLVAAGLVGLDIQWQQEWHSLRVSLQATAPFLHIGAAAGIALLAWPVADTFYRIHRRGPKILLLLLFFGVVLVIYLAPLCISSPCIMEPRDLPPKPGLVGHRGAPMLAPENTLMSLRKTAECGATVFETDVMVSSDGVPFLMHDEHLSRTTNVASVFPTRITAHSSDFSWTELKRLNAGSWFLERRPFWGAKPLAGPDQKEAESQTVPALEELLEEAAALNLSIMFDLRRPPQNHTYYDTFVIQTLETVLNARVPQAMVFWLPDEDRANVQRRAPGMRQIYGRQGGNRTERPQFLNLPYQDLPLLDIKDRFLLPAQAGLKLLASSNLPASASQSAGITGLSHCPPQPPGYKHELSHLAMALHKDNVSVNLFVVNKPWLFSLLWCAGVDSVTTNDCQLLQQMRYPIWLITPQTYLIIWVITNCVSTMLLLWTFLLQRRFVKKRGKTGLETAVLLTRINNFMME
glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform 2
Refseq ID NP_060181
Protein GI 21361649
UniProt ID Q9HCC8
mRNA ID NM_017711
Length 539
RefSeq Status REVIEWED
MAESPGCCSVWARCLHCLYSCHWRKCPRERMQTSKCDCIWFGLLFLTFLLSLSWLYIGLVLLNDLHNFNEFLFRRWGHWMDWSLAFLLVISLLVTYASLLLVLALLLRLCRQPLHLHSLHKVLLLLIMLLVAAGLVGLDIQWQQEWHSLRVSLQATAPFLHIGAAAGIALLAWPVADTFYRIHRRGPKILLLLLFFGVVLVIYLAPLCISSPCIMEPRDLPPKPGLVGHRGAPMLAPENTLMSLRKTAECGATVFETDVMVSSDGVPFLMHDEHLSRTTNVASVFPTRITAHSSDFSWTELKRLNAGSWFLERRPFWGAKPLAGPDQKEAESQTVPALEELLEEAAALNLSIMFDLRRPPQNHTYYDTFVIQTLETVLNARVPQAMVFWLPDEDRANVQRRAPGMRQIYGRQGGNRTERPQFLNLPYQDLPLLDIKALHKDNVSVNLFVVNKPWLFSLLWCAGVDSVTTNDCQLLQQMRYPIWLITPQTYLIIWVITNCVSTMLLLWTFLLQRRFVKKRGKTGLETAVLLTRINNFMME
glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform 3
Refseq ID NP_001164662
Protein GI 284055240
UniProt ID Q9HCC8
mRNA ID NM_001171191
Length 460
RefSeq Status REVIEWED
MDWSLAFLLVISLLVTYASLLLVLALLLRLCRQPLHLHSLHKVLLLLIMLLVAAGLVGLDIQWQQEWHSLRVSLQATAPFLHIGAAAGIALLAWPVADTFYRIHRRGPKILLLLLFFGVVLVIYLAPLCISSPCIMEPRDLPPKPGLVGHRGAPMLAPENTLMSLRKTAECGATVFETDVMVSSDGVPFLMHDEHLSRTTNVASVFPTRITAHSSDFSWTELKRLNAGSWFLERRPFWGAKPLAGPDQKEAESQTVPALEELLEEAAALNLSIMFDLRRPPQNHTYYDTFVIQTLETVLNARVPQAMVFWLPDEDRANVQRRAPGMRQIYGRQGGNRTERPQFLNLPYQDLPLLDIKALHKDNVSVNLFVVNKPWLFSLLWCAGVDSVTTNDCQLLQQMRYPIWLITPQTYLIIWVITNCVSTMLLLWTFLLQRRFVKKRGKTGLETAVLLTRINNFMME
glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform 3
Refseq ID NP_001164664
Protein GI 284055245
UniProt ID Q9HCC8
mRNA ID NM_001171193
Length 460
RefSeq Status REVIEWED
Protein sequence is identical to GI:284055240 (mRNA isoform)

Gene Information

Entrez Gene ID
54857
Gene Name
glycerophosphodiester phosphodiesterase domain containing 2
Gene Symbol
GDPD2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005856 IEA:UniProtKB-KW C cytoskeleton
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0008889 IEA:InterPro F glycerophosphodiester phosphodiesterase activity
GO:0047394 IEA:UniProtKB-EC F glycerophosphoinositol inositolphosphodiesterase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0006071 IEA:InterPro P glycerol metabolic process
GO:0006629 IEA:InterPro P lipid metabolic process

Domain Information

InterPro Annotations

Accession Description
IPR004129 Glycerophosphoryl diester phosphodiesterase
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

UniProt Annotations

Entry Information

Gene Name
glycerophosphodiester phosphodiesterase domain containing 2
Protein Entry
GDPD2_HUMAN
UniProt ID
Q9HCC8
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9HCC8-1; Sequence=Displayed; Name=2; IsoId=Q9HCC8-2; Sequence=VSP_042622; Note=No experimental confirmation available.; Name=3; IsoId=Q9HCC8-3; Sequence=VSP_042623; Note=No experimental confirmation available.;
Catalytic Activity 1-(sn-glycero-3-phospho)-1D-myo-inositol + H(2)O = glycerol + 1D-myo-inositol 1-phosphate.
Caution The catalytic domain of GDPD2 is oriented extracellularly; Glycerophosphoinositol is hydrolyzed in the medium of cells overexpressing Gdpd2, whereas intracellular levels of glycerophosphoinositol is not affected.
Cofactor Name=Ca(2+); Xref=ChEBI
Function Has glycerophosphoinositol inositolphosphodiesterase activity and specifically hydrolyzes glycerophosphoinositol, with no activity for other substrates such as glycerophosphoinositol 4- phosphate, glycerophosphocholine, glycerophosphoethanolamine, and glycerophosphoserine. Accelerates the program of osteoblast differentiation and growth. May play a role in remodeling of the actin cytoskeleton (By similarity).
Sequence Caution Sequence=BAA91014.1; Type=Frameshift; Positions=397; Evidence= ;
Similarity Belongs to the glycerophosphoryl diester phosphodiesterase family.
Similarity Contains 1 GP-PDE domain.
Subcellular Location Cell membrane; Multi-pass membrane protein. Cytoplasm. Cytoplasm, cytoskeleton . Note=Colocalizes with the actin cytoskeleton.

Identical and Related Proteins

Unique RefSeq proteins for LMP003184 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
284055242 RefSeq NP_001164663 590 glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform 1
21361649 RefSeq NP_060181 539 glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform 2
284055240 RefSeq NP_001164662 460 glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform 3

Identical Sequences to LMP003184 proteins

Reference Database Accession Length Protein Name
GI:284055242 DBBJ BAG62641.1 590 unnamed protein product [Homo sapiens]
GI:284055240 DBBJ BAG61286.1 460 unnamed protein product [Homo sapiens]
GI:284055240 DBBJ BAH14406.1 460 unnamed protein product [Homo sapiens]
GI:21361649 GenBank ADL85665.1 539 Sequence 140 from patent US 7704496
GI:21361649 GenBank ADL95750.1 539 Sequence 140 from patent US 7718173
GI:21361649 GenBank AFL59630.1 539 Sequence 140 from patent US 8106156
GI:21361649 GenBank AHD78427.1 539 Sequence 26425 from patent US 8586006
GI:21361649 GenBank AIC56580.1 539 GDPD2, partial [synthetic construct]
GI:284055240 RefSeq NP_001164664.1 460 glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform 3 [Homo sapiens]
GI:284055240 RefSeq XP_003317556.1 460 PREDICTED: glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform X3 [Pan troglodytes]
GI:21361649 RefSeq XP_003820204.1 539 PREDICTED: glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform X1 [Pan paniscus]
GI:284055240 RefSeq XP_003820206.1 460 PREDICTED: glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform X2 [Pan paniscus]
GI:284055240 RefSeq XP_003820207.1 460 PREDICTED: glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform X2 [Pan paniscus]

Related Sequences to LMP003184 proteins

Reference Database Accession Length Protein Name
GI:284055242 GenBank ABP16473.1 539 Sequence 140 from patent US 7189534
GI:284055240 GenBank ABP16473.1 539 Sequence 140 from patent US 7189534
GI:284055242 GenBank ABP19684.1 539 Sequence 140 from patent US 7189806
GI:284055240 GenBank ABP19684.1 539 Sequence 140 from patent US 7189806
GI:284055242 GenBank ABP19960.1 539 Sequence 140 from patent US 7189807
GI:284055240 GenBank ABP19960.1 539 Sequence 140 from patent US 7189807
GI:284055240 GenBank ABP20251.1 539 Sequence 140 from patent US 7189813
GI:284055240 GenBank ABP26399.1 539 Sequence 140 from patent US 7193048
GI:284055240 GenBank ABP26675.1 539 Sequence 140 from patent US 7193049
GI:284055242 GenBank EHH30824.1 590 hypothetical protein EGK_20614 [Macaca mulatta]
GI:284055242 GenBank EHH60968.1 590 hypothetical protein EGM_18874 [Macaca fascicularis]
GI:21361649 RefSeq XP_002831808.1 539 PREDICTED: glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform X1 [Pongo abelii]
GI:21361649 RefSeq XP_003272729.1 539 PREDICTED: glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform 1 [Nomascus leucogenys]
GI:21361649 RefSeq XP_004064376.1 539 PREDICTED: glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform 1 [Gorilla gorilla gorilla]
GI:284055242 RefSeq XP_004064377.1 590 PREDICTED: glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform 2 [Gorilla gorilla gorilla]
GI:21361649 RefSeq XP_005593922.1 569 PREDICTED: glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform X1 [Macaca fascicularis]
GI:21361649 RefSeq XP_005593923.1 539 PREDICTED: glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform X2 [Macaca fascicularis]
GI:21361649 RefSeq XP_007990172.1 539 PREDICTED: glycerophosphoinositol inositolphosphodiesterase GDPD2 isoform X1 [Chlorocebus sabaeus]