Gene/Proteome Database (LMPD)

LMPD ID
LMP003186
Gene ID
236899
Species
Mus musculus (Mouse)
Gene Name
phosphate cytidylyltransferase 1, choline, beta isoform
Gene Symbol
Pcyt1b
Synonyms
AW045697; CTTbeta
Alternate Names
choline-phosphate cytidylyltransferase B; CT B; CCT B; CCT-beta; phosphorylcholine transferase B; CTP:phosphocholine cytidylyltransferase B
Chromosome
X
Map Location
X C3|X
EC Number
2.7.7.15

Proteins

choline-phosphate cytidylyltransferase B isoform 1
Refseq ID NP_997593
Protein GI 46877071
UniProt ID Q811Q9
mRNA ID NM_211138
Length 369
RefSeq Status VALIDATED
MPVLTTDAESETGIPKSLSNEPPSETMEEIEHTCPQPRLTLTAPAPFADESSCQCQAPHEKLTVAQARLGTPVDRPVRVYADGIFDLFHSGHARALMQAKTLFPNSYLLVGVCSDDLTHKFKGFTVMNEAERYEALRHCRYVDEVIRDAPWTLTPEFLEKHKIDFVAHDDIPYSSAGSDDVYKHIKEAGMFVPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKKYRFQNQVDKMKEKVKNVEERSKEFVNRVEEKSHDLIQKWEEKSREFIGNFLELFGPDGAWKQMFQERSSRMLQALSPKQSPVSSPTRSRSPSRSPSPTFSWLPNKTSPPSSPKAASASISSMSEGDEDEK
choline-phosphate cytidylyltransferase B isoform 2
Refseq ID NP_808214
Protein GI 29164513
UniProt ID Q811Q9
mRNA ID NM_177546
Length 339
RefSeq Status VALIDATED
MDKDEFSRKTLTAPAPFADESSCQCQAPHEKLTVAQARLGTPVDRPVRVYADGIFDLFHSGHARALMQAKTLFPNSYLLVGVCSDDLTHKFKGFTVMNEAERYEALRHCRYVDEVIRDAPWTLTPEFLEKHKIDFVAHDDIPYSSAGSDDVYKHIKEAGMFVPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKKYRFQNQVDKMKEKVKNVEERSKEFVNRVEEKSHDLIQKWEEKSREFIGNFLELFGPDGAWKQMFQERSSRMLQALSPKQSPVSSPTRSRSPSRSPSPTFSWLPNKTSPPSSPKAASASISSMSEGDEDEK

Gene Information

Entrez Gene ID
236899
Gene Name
phosphate cytidylyltransferase 1, choline, beta isoform
Gene Symbol
Pcyt1b
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0004105 IEA:UniProtKB-EC F choline-phosphate cytidylyltransferase activity
GO:0001541 IMP:MGI P ovarian follicle development
GO:0007283 IMP:MGI P spermatogenesis

KEGG Pathway Links

KEGG Pathway ID Description
mmu00564 Glycerophospholipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5893602 Synthesis of PC

Domain Information

InterPro Annotations

Accession Description
IPR004821 Cytidyltransferase-like domain
IPR014729 Rossmann-like alpha/beta/alpha sandwich fold

UniProt Annotations

Entry Information

Gene Name
phosphate cytidylyltransferase 1, choline, beta isoform
Protein Entry
PCY1B_MOUSE
UniProt ID
Q811Q9
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=CCTbeta2; IsoId=Q811Q9-1; Sequence=Displayed; Name=2; Synonyms=CCTbeta3; IsoId=Q811Q9-2; Sequence=VSP_020041, VSP_020042; Note=Enzymatic activity identical to isoform 1. Not expressed in embryo. Expression starts at 5 weeks.;
Catalytic Activity CTP + phosphocholine = diphosphate + CDP- choline.
Developmental Stage Expression is low at E7, reaches a maximum at E15 and decreases at E17. {ECO:0000269|PubMed:12842190}.
Disruption Phenotype Female mice lacking isoform 1 have reduced fecundity due to failure in ovary maturation. Male mice lacking isoform 1 have reduced fecundity due to testicular degeneration. {ECO:0000269|PubMed:15143167}.
Function Controls phosphatidylcholine synthesis. {ECO:0000269|PubMed:12842190, ECO:0000269|PubMed:15143167}.
Pathway Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.
Sequence Caution Sequence=BAC27658.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the cytidylyltransferase family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum {ECO:0000250}.
Tissue Specificity Highly expressed in brain (at protein level). Expressed at lower levels in lung and gonads. {ECO:0000269|PubMed:12842190, ECO:0000269|PubMed:15143167}.

Identical and Related Proteins

Unique RefSeq proteins for LMP003186 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
46877071 RefSeq NP_997593 369 choline-phosphate cytidylyltransferase B isoform 1
29164513 RefSeq NP_808214 339 choline-phosphate cytidylyltransferase B isoform 2

Identical Sequences to LMP003186 proteins

Reference Database Accession Length Protein Name
GI:29164513 DBBJ BAC35435.1 339 unnamed protein product [Mus musculus]
GI:46877071 GenBank AAH48917.1 369 Phosphate cytidylyltransferase 1, choline, beta isoform [Mus musculus]
GI:46877071 GenBank EDL29742.1 369 phosphate cytidylyltransferase 1, choline, beta isoform [Mus musculus]
GI:46877071 SwissProt Q811Q9.2 369 RecName: Full=Choline-phosphate cytidylyltransferase B; AltName: Full=CCT-beta; AltName: Full=CTP:phosphocholine cytidylyltransferase B; Short=CCT B; Short=CT B; AltName: Full=Phosphorylcholine transferase B [Mus musculus]

Related Sequences to LMP003186 proteins

Reference Database Accession Length Protein Name
GI:29164513 DBBJ BAE28801.1 339 unnamed protein product [Mus musculus]
GI:29164513 GenBank AAO39005.1 339 CTP:phosphocholine cytidylyltransferase b3 [Mus musculus]
GI:46877071 GenBank EDL96015.1 369 phosphate cytidylyltransferase 1, choline, beta isoform [Rattus norvegicus]
GI:46877071 RefSeq NP_775174.1 369 choline-phosphate cytidylyltransferase B [Rattus norvegicus]
GI:46877071 RefSeq XP_004670052.1 369 PREDICTED: choline-phosphate cytidylyltransferase B [Jaculus jaculus]
GI:46877071 RefSeq XP_005370772.1 369 PREDICTED: choline-phosphate cytidylyltransferase B isoform X1 [Microtus ochrogaster]
GI:29164513 RefSeq XP_005370773.1 343 PREDICTED: choline-phosphate cytidylyltransferase B isoform X2 [Microtus ochrogaster]
GI:29164513 RefSeq XP_006257079.1 349 PREDICTED: choline-phosphate cytidylyltransferase B isoform X2 [Rattus norvegicus]
GI:46877071 RefSeq XP_006990179.1 369 PREDICTED: choline-phosphate cytidylyltransferase B isoform X1 [Peromyscus maniculatus bairdii]
GI:29164513 RefSeq XP_006990180.1 343 PREDICTED: choline-phosphate cytidylyltransferase B isoform X2 [Peromyscus maniculatus bairdii]
GI:46877071 RefSeq XP_008820943.1 369 PREDICTED: choline-phosphate cytidylyltransferase B isoform X1 [Nannospalax galili]
GI:29164513 RefSeq XP_008820944.1 343 PREDICTED: choline-phosphate cytidylyltransferase B isoform X2 [Nannospalax galili]